Publicado 4 números por año
ISSN Imprimir: 0893-9675
ISSN En Línea: 2162-6448
Indexed in
Linking Autophagy and the Dysregulated NFκB/ SNAIL/YY1/RKIP/PTEN Loop in Cancer: Therapeutic Implications
SINOPSIS
The role of autophagy in the pathogenesis of various cancers has been well documented in many reports. Autophagy in cancer cells regulates cell proliferation, viability, invasion, epithelial-to-mesenchymal transition (EMT), metastasis, and responses to chemotherapeutic and immunotherapeutic treatment strategies. These manifestations are the result of various regulatory gene products that govern autophagic, biochemical, and molecular mechanisms. In several human cancer cell models, the presence of a dysregulated circuit—namely, NFκB/SNAIL/YY1/RKIP/PTEN—that plays a major role in the regulation of tumor cell unique characteristics just listed for autophagy-regulated activities. Accordingly, the autophagic mechanism and the dysregulated circuit in cancer cells share many of the same properties and activities. Thus, it has been hypothesized that there must exist a biochemical/molecular link between the two. The present review describes the link and the association of each gene product of the dysregulated circuit with the autophagic mechanism and delineates the presence of crosstalk. Crosstalk between autophagy and the dysregulated circuit is significant and has important implications in the development of targeted therapies aimed at either autophagy or the dysregulated gene products in cancer cells.
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Wang Dapeng, Bao Fuqin, Teng Yugang, Li Qiang, Li Jianjun, MicroRNA-506-3p initiates mesenchymal-to-epithelial transition and suppresses autophagy in osteosarcoma cells by directly targeting SPHK1, Bioscience, Biotechnology, and Biochemistry, 83, 5, 2019. Crossref
-
Gabriela-Freitas , Pinheiro , Raquel-Cunha , Cardoso-Carneiro , Martinho , RKIP as an Inflammatory and Immune System Modulator: Implications in Cancer, Biomolecules, 9, 12, 2019. Crossref
-
Ahmed Mahmoud, Kim Deok Ryong, Anti-cancer effect of RKIP via modulating autophagy during metastasis, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref
-
Özenver Nadire, Efferth Thomas, Therapeutic targeting of SNAIL, RKIP, and YY1 in tumor metastasis and drug resistance, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref
-
Kashfi Khosrow, Zhou Yongxin, Corrente Gabrielle M., RKIP a master of regulatory pathways: Perspectives, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref
-
Wang Yuhao, Bonavida Benjamin, Pleiotropic activities of RKIP in cancer: Role in survival, EMT, chemo-immuno-resistance, and autophagy, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref
-
Shen Bin, Li Yang, Ye Qian, Qin Youyou, YY1-mediated long non-coding RNA Kcnq1ot1 promotes the tumor progression by regulating PTEN via DNMT1 in triple negative breast cancer, Cancer Gene Therapy, 28, 10-11, 2021. Crossref
-
Meliala Ian Timothy Sembiring, Hosea Rendy, Kasim Vivi, Wu Shourong, Yin and Yang of YY1 regulation on tumor metabolic reprogramming, in YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer, 2021. Crossref
-
Bonavida Benjamin, The role of YY1 in drug resistant cancer: Involvement of the YY1/PTEN/PP2A/H2Ax/Rad51 axis, in YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer, 2021. Crossref
-
Yu Qifeng, Zhang Wei, Zhou Xin, Shen Wenqi, Xing Chungen, Yang Xiaodong, Regulation of lnc-TLCD2-1 on Radiation Sensitivity of Colorectal Cancer and Comprehensive Analysis of Its Mechanism, Frontiers in Oncology, 11, 2021. Crossref
-
Yang Fang, Liu Hong, Yu Yonghui, Xu Lin, TRIM9 overexpression promotes uterine leiomyoma cell proliferation and inhibits cell apoptosis via NF-κB signaling pathway, Life Sciences, 257, 2020. Crossref
-
Gundamaraju Rohit, Lu Wenying, Paul Manash K., Jha Niraj Kumar, Gupta Piyush Kumar, Ojha Shreesh, Chattopadhyay Indranil, Rao Pasupuleti Visweswara, Ghavami Saeid, Autophagy and EMT in cancer and metastasis: Who controls whom?, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1868, 9, 2022. Crossref
-
Bonavida Benjamin, Crosstalks between Yin-Yang 1 (YY1) and autophagy in cancer, in Autophagy in Immune Response: Impact on Cancer Immunotherapy, 2020. Crossref
-
Wang Jia, Huang Ping, Pan Xiafang, Xia Chunhua, Zhang Hong, Zhao Han, Yuan Zhao, Liu Jianming, Meng Chao, Liu Fanglan, Resveratrol reverses TGF ‐β1‐mediated invasion and metastasis of breast cancer cells via the SIRT3 / AMPK /autophagy signal axis , Phytotherapy Research, 2022. Crossref
-
Cessna Hannah, Baritaki Stavroula, Zaravinos Apostolos, Bonavida Benjamin, The Role of RKIP in the Regulation of EMT in the Tumor Microenvironment, Cancers, 14, 19, 2022. Crossref