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Critical Reviews™ in Oncogenesis

Publicado 4 números por año

ISSN Imprimir: 0893-9675

ISSN En Línea: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Surveillance of HPV-Positive Head and Neck Squamous Cell Carcinoma with Circulating and Salivary DNA Biomarkers

Volumen 23, Edición 3-4, 2018, pp. 235-245
DOI: 10.1615/CritRevOncog.2018027689
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SINOPSIS

Head and neck squamous cell carcinoma (HNSCC) manifests in the mucosal epithelial lining of the oral cavity, oropharynx, hypopharynx, nasopharynx or larynx and has a tremendous disease burden worldwide. Smoking and alcohol consumption were once major risk factors, but HPV-associated infection has emerged as the major contributor to HNSCC occurrence in developed countries. Circulating biomarker evaluations in biofluids, also known as liquid biopsy, are an attractive alternative for cancer screening as they are minimally invasive, potentially low cost, and easily repeatable on a serial basis. This review summarizes the current knowledge and potential of assessing circulating blood and salivary HPV DNA and HPV antibodies for the surveillance of HPV-positive HNSCC. Additionally, the biological underpinnings of the presence and relevance of circulating HPV DNA is discussed.

CITADO POR
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  2. Payne Karl, Brooks Jill, Spruce Rachel, Batis Nikolaos, Taylor Graham, Nankivell Paul, Mehanna Hisham, Circulating Tumour Cell Biomarkers in Head and Neck Cancer: Current Progress and Future Prospects, Cancers, 11, 8, 2019. Crossref

  3. Keller Laura, Belloum Yassine, Wikman Harriet, Pantel Klaus, Clinical relevance of blood-based ctDNA analysis: mutation detection and beyond, British Journal of Cancer, 124, 2, 2021. Crossref

  4. Flach Susanne, Howarth Karen, Hackinger Sophie, Pipinikas Christodoulos, Ellis Pete, McLay Kirsten, Marsico Giovanni, Forshew Tim, Walz Christoph, Reichel Christoph A., Gires Olivier, Canis Martin, Baumeister Philipp, Liquid BIOpsy for MiNimal RESidual DiSease Detection in Head and Neck Squamous Cell Carcinoma (LIONESS)—a personalised circulating tumour DNA analysis in head and neck squamous cell carcinoma, British Journal of Cancer, 126, 8, 2022. Crossref

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