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Critical Reviews™ in Oncogenesis

Publicado 4 números por año

ISSN Imprimir: 0893-9675

ISSN En Línea: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Sirtuins in Hematological Aging and Malignancy

Volumen 18, Edición 6, 2013, pp. 531-547
DOI: 10.1615/CritRevOncog.2013010187
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SINOPSIS

Aging of the hematological system causes anemia, reduced immunity, and increased incidence of hematological malignancies. Hematopoietic stem cells (HSCs) play a crucial role in this process as their functions decline during aging. Sirtuins are a family of protein lysine modifying enzymes that have diverse roles in regulating metabolism, genome stability, cell proliferation, and survival, and have been implicated in mammalian aging and longevity. Here we provide an updated overview of sirtuins in aging research; particularly, how increased activity of SIRT1, SIRT3, or SIRT6 improves several aging parameters, and may possibly increase lifespan in mice. We review the literature on how sirtuins may play a role in HSC aging and hematological malignancies, and how key signaling pathways of HSCs may be affected by sirtuins. Among them, SIRT1 plays a critical role in chronic myelogenous leukemia, an age-dependent malignancy, and inhibition of SIRT1 sensitizes leukemic stem cells to tyrosine kinase inhibitor treatment and blocks acquisition of resistant oncogene mutations. In-depth understanding of sirtuins in HSC aging and malignancy may help design novel strategies to deter hematological aging and improve treatment of hematological malignancies.

CITADO POR
  1. Perdiguero E., García-Prat L., Sousa-Victor P., Muñoz-Cánoves P., Stem Cells and Aging, in Encyclopedia of Cell Biology, 2016. Crossref

  2. Tomita Takuya, Hamazaki Jun, Hirayama Shoshiro, McBurney Michael W., Yashiroda Hideki, Murata Shigeo, Sirt1-deficiency causes defective protein quality control, Scientific Reports, 5, 1, 2015. Crossref

  3. Kuranova M. L., Pleskach N. M., Ledashcheva T. A., Mikhelson V. M., Spivak I. M., Mosaic forms of ataxia telangiectasia, Cell and Tissue Biology, 9, 1, 2015. Crossref

  4. Varshavi Dorsa, Scott Flora H., Varshavi Dorna, Veeravalli Sunil, Phillips Ian R., Veselkov Kirill, Strittmatter Nicole, Takats Zoltan, Shephard Elizabeth A., Everett Jeremy R., Metabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice, Frontiers in Molecular Biosciences, 5, 2018. Crossref

  5. Pellagatti Andrea, Armstrong Richard N., Steeples Violetta, Sharma Eshita, Repapi Emmanouela, Singh Shalini, Sanchi Andrea, Radujkovic Aleksandar, Horn Patrick, Dolatshad Hamid, Roy Swagata, Broxholme John, Lockstone Helen, Taylor Stephen, Giagounidis Aristoteles, Vyas Paresh, Schuh Anna, Hamblin Angela, Papaemmanuil Elli, Killick Sally, Malcovati Luca, Hennrich Marco L., Gavin Anne-Claude, Ho Anthony D., Luft Thomas, Hellström-Lindberg Eva, Cazzola Mario, Smith Christopher W. J., Smith Stephen, Boultwood Jacqueline, Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations, Blood, 132, 12, 2018. Crossref

  6. Hao Taisen, Li-Talley Min, Buck Alison, Chen WenYong, An emerging trend of rapid increase of leukemia but not all cancers in the aging population in the United States, Scientific Reports, 9, 1, 2019. Crossref

  7. Pellagatti Andrea, Boultwood Jacqueline, Splicing factor mutant myelodysplastic syndromes: Recent advances, Advances in Biological Regulation, 75, 2020. Crossref

  8. Follo Matilde Y., Pellagatti Andrea, Ratti Stefano, Ramazzotti Giulia, Faenza Irene, Fiume Roberta, Mongiorgi Sara, Suh Pann-Ghill, McCubrey James A., Manzoli Lucia, Boultwood Jacqueline, Cocco Lucio, Recent advances in MDS mutation landscape: Splicing and signalling, Advances in Biological Regulation, 75, 2020. Crossref

  9. Watroba Mateusz, Szukiewicz Dariusz, Sirtuins at the Service of Healthy Longevity, Frontiers in Physiology, 12, 2021. Crossref

  10. Vazquez Berta N., Fernández-Duran Irene, Vaquero Alejandro, Sirtuins in hematopoiesis and blood malignancies, in Sirtuin Biology in Medicine, 2021. Crossref

  11. Banerjee Suvankar, Amin Sk. Abdul, Jha Tarun, Therapies of Hematological Malignancies: An Overview of the Potential Targets and Their Inhibitors, Current Chemical Biology, 15, 1, 2021. Crossref

  12. Wang Zhiqiang, Zhang Chunxiao, Warden Charles David, Liu Zheng, Yuan Yate-Ching, Guo Chao, Wang Charles, Wang Jinhui, Wu Xiwei, Ermel Richard, Vonderfecht Steven L., Wang Xiuli, Brown Christine, Forman Stephen, Yang Yaling, James You M., Chen WenYong, Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia, Communications Biology, 5, 1, 2022. Crossref

  13. Wang Pan, Wang Zi, Liu Jing, Role of HDACs in normal and malignant hematopoiesis, Molecular Cancer, 19, 1, 2020. Crossref

  14. Nowicki Mateusz, Wierzbowska Agnieszka, Stec-Martyna Emilia, Kulczycka-Wojdala Dominika, Nowicki Grzegorz, Szmigielska-Kapłon Anna, SIRT1-SIRT7 Expression in Patients with Lymphoproliferative Disorders Undergoing Hematopoietic Stem Cell Mobilization, Cancers, 14, 5, 2022. Crossref

  15. Wang Zhiqiang, Chen Ching-Cheng, Chen WenYong, CD150− Side Population Defines Leukemia Stem Cells in a BALB/c Mouse Model of CML and Is Depleted by Genetic Loss of SIRT1, Stem Cells, 33, 12, 2015. Crossref

  16. Kim Tae Hoon, Young Steven L, Sasaki Tsutomu, Deaton Jeffrey L, Schammel David P, Palomino Wilder Alberto, Jeong Jae-Wook, Lessey Bruce A, Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium, The Journal of Clinical Endocrinology & Metabolism, 107, 3, 2022. Crossref

  17. Mehrpouri Mahdieh, Pourbagheri-Sigaroodi Atieh, Bashash Davood, The contributory roles of histone deacetylases (HDACs) in hematopoiesis regulation and possibilities for pharmacologic interventions in hematologic malignancies, International Immunopharmacology, 100, 2021. Crossref

  18. Perdiguero Eusebio, García-Prat Laura, Sousa-Victor Pedro, Muñoz-Cánoves Pura, Stem Cells and Aging, in Reference Module in Life Sciences, 2022. Crossref

  19. Vong Pascal, Ouled-Haddou Hakim, Garçon Loïc, Histone Deacetylases Function in the Control of Early Hematopoiesis and Erythropoiesis, International Journal of Molecular Sciences, 23, 17, 2022. Crossref

  20. Goes João Vitor Caetano, Carvalho Luiz Gustavo, de Oliveira Roberta Taiane Germano, Melo Mayara Magna de Lima, Novaes Lázaro Antônio Campanha, Moreno Daniel Antunes, Gonçalves Paola Gyuliane, Montefusco-Pereira Carlos Victor, Pinheiro Ronald Feitosa, Ribeiro Junior Howard Lopes, Role of Sirtuins in the Pathobiology of Onco-Hematological Diseases: A PROSPERO-Registered Study and In Silico Analysis, Cancers, 14, 19, 2022. Crossref

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