Publicado 6 números por año
ISSN Imprimir: 1045-4403
ISSN En Línea: 2162-6502
Indexed in
Chromosomal DNA Loops May Constitute Basic Units of the Eukaryotic Genome Organization and Evolution
SINOPSIS
In eukaryotic cell nuclei the genome is organized into large loops attached to the nuclear matrix. Rearrangements of the genome frequently occur via an illegitimate recombination between loop anchorage sites resulting in deletion or repositioning of DNA loops. The illegitimate recombination between loop anchorage sites is possibly mediated by topoisomerase II. Treatments stabilizing intermediate covalent complexes of topoisomerase II with DNA seem to increase the possibility of illegitimate recombination between loop anchorage regions. On the basis of these and some other observations we suggest that chromosomal DNA loops constitute basic units of the genome evolution, or, in other words, structural blocks of the eukaryotic genome.
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Kantidze Omar L., Iarovaia Olga V., Razin Sergey V., Assembly of nuclear matrix–bound protein complexes involved in non-homologous end joining is induced by inhibition of DNA topoisomerase II, Journal of Cellular Physiology, 207, 3, 2006. Crossref
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Tolstonog Genrich V., Mothes Elfriede, Shoeman Robert L., Traub Peter, Isolation of SDS-Stable Complexes of the Intermediate Filament Protein Vimentin with Repetitive, Mobile, Nuclear Matrix Attachment Region, and Mitochondrial DNA Sequence Elements from Cultured Mouse and Human Fibroblasts, DNA and Cell Biology, 20, 9, 2001. Crossref
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Tolstonog Genrich V., Sabasch Michael, Traub Peter, Cytoplasmic Intermediate Filaments Are Stably Associated with Nuclear Matrices and Potentially Modulate Their DNA-Binding Function, DNA and Cell Biology, 21, 3, 2002. Crossref
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Brunetti Roberta, Prosseda Gianni, Beghetto Elisa, Colonna Bianca, Micheli Gioacchino, The looped domain organization of the nucleoid in histone-like protein defective Escherichia coli strains***This work is dedicated to Maurice Hofnung, tragically deceased on June 28th, 2001., Biochimie, 83, 9, 2001. Crossref
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Guadarrama‐Ponce Rolando, Aranda‐Anzaldo Armando, The epicenter of chromosomal fragility of Fra14A2, the mouse ortholog of human FRA3B common fragile site, is largely attached to the nuclear matrix in lymphocytes but not in other cell types that do not express such a fragility, Journal of Cellular Biochemistry, 121, 3, 2020. Crossref
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Shimizu Noriaki, Shingaki Kenta, Macroscopic folding and replication of the homogeneously staining region in late S phase leads to the appearance of replication bands in mitotic chromosomes, Journal of Cell Science, 117, 22, 2004. Crossref
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Iarovaia Olga V., Shkumatov Petr, Razin Sergey V., Breakpoint cluster regions of the AML-1 and ETO genes contain MAR elements and are preferentially associated with the nuclear matrix in proliferating HEL cells, Journal of Cell Science, 117, 19, 2004. Crossref
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Razin Sergey V., Zhegalova Irina V., Kantidze Omar L., Domain Model of Eukaryotic Genome Organization: From DNA Loops Fixed on the Nuclear Matrix to TADs, Biochemistry (Moscow), 87, 7, 2022. Crossref
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