Suscripción a Biblioteca: Guest
International Journal of Physiology and Pathophysiology

Publicado 4 números por año

ISSN Imprimir: 2155-014X

ISSN En Línea: 2155-0158

SJR: 0.116

Modulation of Na+, K+-ATPase Activity in the Medulla Oblongata Neurons Affects Hemodynamics in Spontaneously Hypertensive Rats

Volumen 4, Edición 2, 2013, pp. 123-136
DOI: 10.1615/IntJPhysPathophys.v4.i2.50
Get accessGet access

SINOPSIS

The study was conducted on rats with normal arterial pressure (control) and spontaneously hypertensive rats, anesthetized with urethane (1600 mg / kg, i.p.). It has been shown that injections of ouabain (10−8 − 10−6 mol/), a specific Na+, K+-ATPase inhibitor, in the cardiovascular nuclei (nucleus tractus solitarius, NTS; paramedian reticular nucleus, PMn; lateral reticular nucleus, LRN) of the control rats are usually accompanied by a dose-dependent rise in the systemic arterial pressure. In spontaneously hypertensive rats, injections of ouabain in the studied medullary nuclei result in either hypertensive responses, which are more pronounced than those in the control rats, or hypotensive responses. An activation of Na+, K+-ATPase by injections of asparcam in the cardiovascular neurons within the medullary nuclei results in the development of hypotensive responses in both control animals and spontaneously hypertensive rats, but in the latter effect is more pronounced. In biochemical study, Na+, K+-ATPase activity in the microsomal fraction of the medulla oblongata of spontaneously hypertensive rats has been found to be 61.8% higher than the enzyme activity in normotensive animals. These data suggest that Na+, K+-ATPase of the cell plasmatic membranes in the medullary cardiovascular nuclei is involved in the neural control of blood circulation, and its inhibition promotes hypertension of central origin.

2841 Vistas de artículos 2 Descargas de artículos Métrica
2841 PUNTOS DE VISTA 2 DESCARGAS Google
Scholar
CITAS

Artículos con contenido similar:

Influence of Intermittent Hypoxic Training on Hemodynamic Effects of NOS-1 Activation in Medullary Cardiovascular Neurons in Rats International Journal of Physiology and Pathophysiology, Vol.1, 2010, issue 4
Lyudmila M. Shapoval, Lyubov G. Stepanenko, Vitali O. Bouryi, Vadim F. Sagach, Lyudmila S. Pobegaylo, Olga V. Dmytrenko
Activation of Endogenous Hydrogen Sulfide Synthesis Inhibits Mitochondrial Permeability Transition Pore Opening and Restores Constitutive NO-Synthase Coupling in Old Rat Heart International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 1
Nataliya A. Strutynska, V. R. Strutynskyi, Lidiya A. Mys, Vadim F. Sagach
Inhibition of Mitochondrial Hydrogen Sulfide Production Worsens Heart Contractility and Enhances Sensitivity of Mitochondrial Permeability Transition Pore to Calcium International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 2
Nataliya A. Strutynska, Alina Yu. Luchkova, Vadim F. Sagach, Yuliya V. Hoshovs'ka, Raisa A. Fedichkina
Increased Sensitivity of Mitochondrial Permeability Transition Pore to Ca2+ in the Heart of Spontaneously Hypertensive Rats International Journal of Physiology and Pathophysiology, Vol.4, 2013, issue 3
Nataliya A. Strutynska, Galyna L. Vavilova, Vadim F. Sagach, Nataliya A. Dorofeyeva
Hydrogen Sulfide Inhibits Calcium-Induced Mitohondrial Permeability Transition Pore Opening in the Heart of Adult and Old Rats International Journal of Physiology and Pathophysiology, Vol.3, 2012, issue 2
Snizhana V. Chorna, Nataliya A. Strutynska, Galyna L. Vavilova, Vadim F. Sagach, Olena M. Semenykhina

Último edicion

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones Precios y Políticas de Suscripcione Begell House Contáctenos Language English 中文 Русский Português German French Spain