Suscripción a Biblioteca: Guest
International Journal of Physiology and Pathophysiology

Publicado 4 números por año

ISSN Imprimir: 2155-014X

ISSN En Línea: 2155-0158

SJR: 0.116

Changes in Myocardium Metabolism in Ischemia-Reperfusion and Activation of ATP-Sensitive Potassium Channels

Volumen 3, Edición 3, 2012, pp. 253-267
DOI: 10.1615/IntJPhysPathophys.v3.i3.60
Get accessGet access

SINOPSIS

In experiments on anaesthetized dogs with simulated experimental ischemia (90 min) and reperfusion (180 min), changes in biochemical parameters were studied in different sites of the heart: intact, risk and necrotic zones after an intraventricular administration of dosage forms (tablets) of flokalin, a fluorine-containing activator of adenosine triphosphate (ATP) -sensitive potassium (KATP) -channels in a dose of 2.2 mg/kg. We examined biochemical indicators that may be defined as possible mechanisms of flokalin action, such as: oxidative metabolism (pools of H2O2, uric acid, diene conjugates, malondialdehyde, eicosanoids LTC4 and TxB2), different ways of NO biosynthesis − oxidative de novo (activity of inducible and constitutive NO-synthase and citrulline pools) and non-oxidizing salvage way (nitrate reductase activity), pools of stable NO metabolites (nitrite and nitrate anions, low and high molecular nitrosothiols), inorganic phosphate and other degradation products of ATP and guanidine triphosphate (GTP), changes in hemoxygenase reaction (pools of bilirubin and iron), non-oxidizing catabolism of L-arginine (arginase activity and pools of urea), and the content of free arachidonic acid. An analysis of the results allowed us to identify several possible cardioprotective mechanisms of flokalin. They involve an inhibition of oxidative metabolism due to limitations of the generation of free oxygen and nitrogen radicals, inhibition of the phospholipid hydrolysis, and thereby formation of free arachidonic acid and pathogenic in myocardial ischemia eicosanoids, inhibition of ATP and GTP degradation, and perhaps stimulation of a protective hemoxygenase response. Inhibition of the inducible de novo and salvage synthesis of nitric oxide, degradation of arginine by arginase and, conversely, maintaining of adequate levels of constitutive de novo nitric oxide synthesis can be considered as an important cardioprotective mechanism. At the same time, preserving the latter on the high level, and above changes in oxidative metabolism that prevent toxic peroxynitrite formation indicate the possibility of flokalin to participate in the cardioprotective effect by preventing mitochondrial permeability transition pore opening and, consequently, inhibiting apoptosis and / or necrosis of cardiomyocytes.

589 Vistas de artículos 11 Descargas de artículos Métrica
589 PUNTOS DE VISTA 11 DESCARGAS Google
Scholar
CITAS

Artículos con contenido similar:

Biochemical Mechanisms of Cardioprotective Action of the Drug Product Flocalin, ATP-Sensitive K+ Channel Opener, in Myocardial Ischemia −Reperfusion International Journal of Physiology and Pathophysiology, Vol.5, 2014, issue 3
Nataliya A. Strutynska, Roman A. Rovenets, Ruslan B. Strutynskyi, Vadim F. Sagach, Anatoliy V. Kotsuruba, Oleksiy O. Moibenko, Yuriy L. Yagupolskii
Rising of Constitutive NO-Synthase Coupling and Hemoglobin Content in Erythrocytes of Old Animals by Iron- Containing Herbal Drug International Journal of Physiology and Pathophysiology, Vol.8, 2017, issue 3
S. I. Uretii, Anatoliy V. Kotsuruba, Bogdan S. Kopyak
Activation of Endogenous Hydrogen Sulfide Synthesis Inhibits Mitochondrial Permeability Transition Pore Opening and Restores Constitutive NO-Synthase Coupling in Old Rat Heart International Journal of Physiology and Pathophysiology, Vol.9, 2018, issue 1
Nataliya A. Strutynska, V. R. Strutynskyi, Lidiya A. Mys, Vadim F. Sagach
Changes in Arginase-Nitric Oxide Synthase System at Adaptation to Prolonged Exercise Training by Swimming in Adult and Aged Rat Hearts International Journal of Physiology and Pathophysiology, Vol.3, 2012, issue 4
Yulia P. Korkach, Lyubov G. Stepanenko, Olga V. Bazilyuk, Vadim F. Sagach, Anatoliy V. Kotsuruba, Sergiy O. Talanov
Age-Associated Mitochondrial Dysfunction in the Heart Accompanied by Constitutive NO-Synthases Uncoupling on the Background of Oxidative and Nitrosative Stress International Journal of Physiology and Pathophysiology, Vol.8, 2017, issue 2
Nataliya A. Strutynska, Lidiya A. Mys, Alina Yu. Budko, Vadim F. Sagach, Anatoliy V. Kotsuruba

Último edicion

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Portal Digitalde Biblioteca Digital eLibros Revistas Referencias y Libros de Ponencias Colecciones Precios y Políticas de Suscripcione Begell House Contáctenos Language English 中文 Русский Português German French Spain