Publicado 12 números por año
ISSN Imprimir: 1521-9437
ISSN En Línea: 1940-4344
IF:
1.2
5-Year IF:
1.4
Immediacy Index:
0.3
Eigenfactor:
0.00066
JCI:
0.34
SJR:
0.274
SNIP:
0.41
CiteScore™::
2.8
H-Index:
37
Indexed in
Preparation of Black Hoof Medicinal Mushroom Phellinus linteus (Berk. et M.A. Curt.) Teng (Aphyllophoromycetideae) (β-Glucan Sulfate and In Vitro Tumor Cell Growth Inhibitory Activity
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SINOPSIS
Polysaccharide β-glucans were extracted from the medicinal mushroom Phellinus linteus (Hymenochaetaceae, Aphyllophoromycetideae) and subjected to sulfation. Chemical modification of the β-glucan was confirmed by structural analysis, and its biological properties were compared with those of native β-glucan. The results of Fourier transform infrared spectroscopy and elemental analysis indicated that successive preparation of the sulfated derivative yielded a degree of substitution of 0.47. Nitric oxide production measured by the bronchoalveolar lavage (BAL) experiments increased 1.5-fold after sulfation. In addition, the introduction of sulfate groups into the β-glucan chains improved in vitro growth inhibitory activity against SNU-C2A cells. Therefore, sulfated β-glucan extracted from Ph. Linteus may be beneficial for immune support due to its incorporation of functional groups into its polymer structure.
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Zhao Chao, Liao Zunsheng, Wu Xiaoqi, Liu Yanling, Liu Xiaoyan, Lin Zhanxi, Huang Yifan, Liu Bin, Isolation, Purification, and Structural Features of a Polysaccharide fromPhellinus linteusand Its Hypoglycemic Effect in Alloxan-Induced Diabetic Mice, Journal of Food Science, 79, 5, 2014. Crossref
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UEBABA Kazuo, SUZUKI Nobutaka, XU FengHao, KAWABATA Toshiki, URATA Teturo, KAWABATA Katsushi, Safety and Usefulness of Fucoidan and Mushroom Extracts: an Open Clinical Trial, Japanese Journal of Complementary and Alternative Medicine, 10, 2, 2013. Crossref
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Kothari Damini, Patel Seema, Kim Soo-Ki, Anticancer and other therapeutic relevance of mushroom polysaccharides: A holistic appraisal, Biomedicine & Pharmacotherapy, 105, 2018. Crossref