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International Journal of Medicinal Mushrooms

Publicado 12 números por año

ISSN Imprimir: 1521-9437

ISSN En Línea: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Th1-Oriented Immunomodulating Activity of Gel-Forming Fungal (1®3)-Beta-Glucans

Volumen 4, Edición 2, 2002, 16 pages
DOI: 10.1615/IntJMedMushr.v4.i2.30
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SINOPSIS

The immunomodulating effects of various gel-forming (1®3)-beta-glucans on balancing helper T-cell activity were examined in a murine model. Plasma from mice injected with grifolan (GRN) from the edible and medicinal mushroom Grifola frondosa (Dicks.: Fr.) S. F. Gray [or alkaline-treated sonifilan (SPG-OH)] and trinitrophenyl ovalbumin (TNP-OVA) contained TNP-specific antibodies of both IgG1 (Th2-mediated) and IgG2a (Th1-mediated) isotypes. Administration of glucan (SSG) from Sclerotinia sclerotiorum (Lib.) de Bary IFO 9395 and TNP-OVA significantly augmented the synthesis of IgG2a antibodies, while the synthesis of IgG1 was reduced. Furthermore, intracellular cytokine staining showed a higher proportion of IFN-g-producing helper T cells in SSG-administered murine splenocytes. The highest IFN-g production was observed when adherent cells of mice administered TNP-OVA and SSG were cultured with TNP-primed lymphocytes. This effect of administration of SSG on IFN-g production was completely inhibited by addition of anti-IL-12 mAb. The content of the reduced form of glutathione in splenocytes was increased by SSG administration, suggesting type 1 immunoresponse. Depletion of lymphoid dendritic cell population from SSG-administered splenocytes reduced IFN-g production. In conclusion, our study showed that beta-glucans have various effects on the Th1- or Th2-dependent antibody subclasses and, in particular, that SSG induces the development of Th1 cells via the IL-12 pathway.

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