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International Journal of Medicinal Mushrooms

Publicado 12 números por año

ISSN Imprimir: 1521-9437

ISSN En Línea: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Effect of Polysaccharides and 70% Ethanol Extracts from Medicinal Mushrooms on Growth of Human Prostate Cancer LNCaP and PC-3 Cells

Volumen 12, Edición 2, 2010, pp. 205-211
DOI: 10.1615/IntJMedMushr.v12.i2.120
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SINOPSIS

To find anticancer compounds in medicinal mushrooms (MM), we fi rst examined the effect of polysaccharides and ethanol extracts of MM on cell growth. Some heteroglycans from MM and antitumor glucans significantly suppressed the growth of prostate cancer cell lines, LNCaP and PC-3 cells. However, no structure-activity relationship among them was observed. A 70% ethanol extract of mushrooms markedly inhibited the cell growth of LNCaP and PC-3 cells, and the effect was greater than the above polysaccharides. The 70% ethanol extract of the fruiting bodies of Tremella aurantia (TA-70E) showed the most potent inhibitory effect on cell growth—that is, treated with 1 mg/mL of TA-70E for 48 h cell viability decreased to about 12% and 32% of the levels in the control of LNCaP and PC-3 cells, respectively. In addition, the growth inhibition of LNCaP and PC-3 cells by the 70% ethanol extract was, at least in part, characterized by G2/M phase cell cycle arrest, as evidenced by FACS analysis. These results showed that the polysaccharides and 70% ethanol extract of mushrooms have growth-inhibitory activity in LNCaP and PC-3 cells.

CITADO POR
  1. Deng Chao, Sun Yuanyuan, Fu Haitian, Zhang Sixiu, Chen Jinghua, Xu Xin, Antioxidant and immunostimulatory activities of polysaccharides extracted from Tremella aurantialba mycelia, Molecular Medicine Reports, 14, 5, 2016. Crossref

  2. MIURA Yoko, OYAMA Masayoshi, IGUCHI Kazuhiro, ITO Tetsuro, BABA Misako, SHIKAMA Yuji, USUI Shigeyuki, HIRANO Kazuyuki, IINUMA Munekazu, MIKAMO Hiroshige, Anti-Androgenic Activity of Icarisid II from Epimedium Herb in Prostate Cancer LNCaP Cells, Journal of Nutritional Science and Vitaminology, 61, 2, 2015. Crossref

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