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International Journal of Medicinal Mushrooms

Publicado 12 números por año

ISSN Imprimir: 1521-9437

ISSN En Línea: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Compound of Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Agaricomycetes), Induces Protective Autophagy in SPCA-1 Cells through AMPK Inhibition-Independent Blockade of the Akt/mTOR Pathway

Volumen 20, Edición 8, 2018, pp. 727-738
DOI: 10.1615/IntJMedMushrooms.2018026983
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SINOPSIS

Our previous study showed that By-1, a maleimide derivative isolated from Taiwanofungus camphoratus, could induce reactive oxygen species-triggered apoptosis and G2 cell cycle arrest through a caspase-dependent pathway and also induced protective autophagy in human lung cancer SPCA-1 cells. Here, we further examined the autophagy flux and detected related proteins by Western blot analysis and fluorescence activated cell sorting, and we sought to find the exact role and underlying pathway of autophagy in SPCA-1 cells. Our results showed that By-1 treatment activated autophagy flux in SPCA-1 cells, which further confirmed that autophagy was induced by By-1 treatment in our previous study. Autophagy activator rapamycin restored cell death from By-1 treatment (21.32%) and verified that autophagy played a protective role in By-l-treated cells. Meanwhile, By-1 treatment suppressed the Akt-mammalian target of rapamycin (mTOR) pathway and the AMP-activated protein kinase (AMPK) pathway. Taken together, these findings indicate that By-1 induced protective autophagy in SPCA-1 cells through AMPK inhibition-independent blockade of the Akt/mTOR pathway.

CITADO POR
  1. Hung Hsin-Yi, Hung Chin-Chuan, Liang Jun-Weil, Chen Chin-Fu, Chen Hung-Yi, Shieh Po-Chuen, Kuo Ping-Chung, Wu Tian-Shung, Constituents and Anti-Multidrug Resistance Activity of Taiwanofungus camphoratus on Human Cervical Cancer Cells, Molecules, 24, 20, 2019. Crossref

  2. Pan Haitao, Wang Yujie, Na Kun, Wang Ying, Wang Lu, Li Zhenhao, Guo Chengjie, Guo Dandan, Wang Xingya, Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation, Cell Death & Disease, 10, 6, 2019. Crossref

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