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International Journal of Medicinal Mushrooms

Publicado 12 números por año

ISSN Imprimir: 1521-9437

ISSN En Línea: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

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Inhibitory Effect of Ethyl Acetate Extract of the Shaggy Inc Cap Medicinal Mushroom, Coprinus comatus (Higher Basidiomycetes) Fruit Bodies on Cell Growth of Human Ovarian Cancer

Volumen 15, Edición 5, 2013, pp. 457-470
DOI: 10.1615/IntJMedMushr.v15.i5.40
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SINOPSIS

In a previous study, we screened organic extracts of different mushroom mycelia and picked ethyl acetate extract of Coprinus comatus as one of the most active extracts against human ovarian cancer cells. In the current study, we extracted a dry powder of C. comatus fruit bodies using ethyl acetate and examined its effect on the viability of three cell lines originated from human ovarian cancer (ES-2, SKOV-3, and SW-626). This extract was active against all tested cell lines, in a dose-dependent manner (concentrations 50−200 µg/mL, P<0.01). In an attempt to segregate the active fraction, we subjected the extract to chromatography on a silica gel column. The effect of six different fractions and of the crude extract on the viability of ES-2 cells was examined after exposure time of 24 h. Fraction F (last eluted) was significantly more effective than crude extract in the reduction of cell viability (P<0.01). Fraction F was also significantly more active than crude extract in the reduction of viability of SKOV-3 cells. We next identified some of the compounds of fraction F (mainly fatty acids) by gas chromatography−mass spectrometry. In summary, ethyl acetate extract of C. comatus reduced viability of three lines of human ovarian cancer. Fractionation of this extract by a silica gel column enabled the selection of a fraction significantly more active than the original extract.

CITADO POR
  1. Zhao Shuang, Rong Cheng-Bo, Kong Chang, Liu Yu, Xu Feng, Miao Qian-Jiang, Wang Shou-Xian, Wang He-Xiang, Zhang Guo-Qing, A Novel Laccase with Potent Antiproliferative and HIV-1 Reverse Transcriptase Inhibitory Activities from Mycelia of MushroomCoprinus comatus, BioMed Research International, 2014, 2014. Crossref

  2. Park Ki Moon, Kwon Kyung Min, Lee Seung Ho, Evaluation of the Antioxidant Activities and Tyrosinase Inhibitory Property from Mycelium Culture Extracts, Evidence-Based Complementary and Alternative Medicine, 2015, 2015. Crossref

  3. Cao Hui, Ma Shan, Guo Hong, Cui Xiaowei, Wang Shanshan, Zhong Xiaofei, Wu Yumeng, Zheng Wenxiu, Wang Haonan, Yu Jiyang, Ma Luyu, Chun-chao Han, Comparative study on the monosaccharide compositions, antioxidant and hypoglycemic activities in vitro of intracellular and extracellular polysaccharides of liquid fermented Coprinus comatus, International Journal of Biological Macromolecules, 139, 2019. Crossref

  4. Nowakowski Patryk, Naliwajko Sylwia K., Markiewicz‐Żukowska Renata, Borawska Maria H., Socha Katarzyna, The two faces of Coprinus comatus —Functional properties and potential hazards , Phytotherapy Research, 34, 11, 2020. Crossref

  5. Turło Jadwiga, The biotechnology of higher fungi - current state and perspectives, Folia Biologica et Oecologica, 10, 2014. Crossref

  6. Nowakowski Patryk, Markiewicz-Żukowska Renata, Gromkowska-Kępka Krystyna, Naliwajko Sylwia Katarzyna, Moskwa Justyna, Bielecka Joanna, Grabia Monika, Borawska Maria, Socha Katarzyna, Mushrooms as potential therapeutic agents in the treatment of cancer: Evaluation of anti-glioma effects of Coprinus comatus, Cantharellus cibarius, Lycoperdon perlatum and Lactarius deliciosus extracts, Biomedicine & Pharmacotherapy, 133, 2021. Crossref

  7. Dimopoulou Maria, Kolonas Alexandros, Mourtakos Stamatis, Androutsos Odysseas, Gortzi Olga, Nutritional Composition and Biological Properties of Sixteen Edible Mushroom Species, Applied Sciences, 12, 16, 2022. Crossref

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