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Critical Reviews™ in Neurobiology

Publicado 3 números por año

ISSN Imprimir: 0892-0915

ISSN En Línea: 2375-0014

SJR: 0.121

Neurobiology of Nitric Oxide

Volumen 10, Edición 3-4, 1996, pp. 291-316
DOI: 10.1615/CritRevNeurobiol.v10.i3-4.20
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SINOPSIS

Nitric oxide is a ubiquitous and unique biological messenger molecule. It mediates blood vessel relaxation by endothelium, immune function of macrophages, and neurotransmission of central and peripheral nervous systems. Endothelial and neuronal nitric oxide synthases are constitutively expressed and activated by calcium entry into cells, whereas the macrophage nitric oxide synthase is inducible with new RNA and protein synthesis upon immune stimulation. Nitric oxide may play a role in the neurotransmitter release, neural development, synaptic plasticity, and regulation of gene expression. Excessive production of nitric oxide is neurotoxic and is implicated in a variety of neurological disorders.

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