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Critical Reviews™ in Neurobiology

Publicado 3 números por año

ISSN Imprimir: 0892-0915

ISSN En Línea: 2375-0014

SJR: 0.121

GABA Physiology: Modulation by Benzodiazepines and Hormones

Volumen 10, Edición 1, 1996, pp. 1-37
DOI: 10.1615/CritRevNeurobiol.v10.i1.10
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SINOPSIS

This review compares the ability of acute and chronic benzodiazepine treatments (BZs), gonadal hormone treatments, and neurosteroids to modify gamma-aminobutyric acid (GABA) physiologic responses in animals. Both BZ ligands and certain "neurosteroid" derivatives of steroid hormones can modulate GABA responses through direct interactions with the GABA receptor complex. Fluctuations in gonadal steroids can be anticonvulsant or proconvulsant, anxiolytic or anesthetic, suggesting a pharmacologic profile comparable to that of the BZs. A comparison of neuronal physiological responses in spinal cord, hippocampus, amygdala, hypothalamus-preoptic area, cerebellum, dorsal raphe, locus coeruleus, and cortex indicates that both acute and chronic BZ treatments produce region-specific effects on in vivo GABAergic responses. This appears to be based on regional variability in intrinsic sensitivity to GABA and/or BZ ligands, the level of ongoing GABA neurotransmission in a region, and the indirect influences of BZs on afferent inputs to an area. Regionally specific adaptations to chronic BZ treatments that lead to the development of tolerance include the following: intrinsic sub sensitivity to GABA, reduced activity in GABAergic circuits (e.g., reduced recurrent inhibition in hippocampus), attenuated responses to BZs without alterations in GABA sensitivity, modulation of the intrinsic properties of neurons, and alterations in the activity of non-GABAergic afferent inputs. The in vivo evidence that neurosteroid derivatives modify physiological responses to GABA is also beginning to emerge. Progesterone, through conversion to its neurosteroid metabolite 3α-OH DHP, potentiates GABA responses of cerebellar Purkinje cells. This neurosteroid also enhances GABA responses in hippocampal slices, including recurrent inhibition, in a BZ-like manner. Despite the evidence that fluctuations in estrogen levels can modulate several aspects of GABA neurotransmission, neither in vivo estrogen treatments nor in vitro administration of estrogen to brain slices clearly modifies physiological GABA responses. Although estrogens alter excitability in several areas, these changes are associated with estrogenic effects on responses to excitatory neurotransmitters or inputs. Relatively few studies have examined the in vivo influences of androgenic steroids on GABA responses.

CITADO POR
  1. Varlinskaya Elena I., Spear Linda P., Differences in the social consequences of ethanol emerge during the course of adolescence in rats: Social facilitation, social inhibition, and anxiolysis, Developmental Psychobiology, 48, 2, 2006. Crossref

  2. Ladd Charlotte O., Huot Rebecca L., Thrivikraman K.V., Nemeroff Charles B., Meaney Michael J., Plotsky Paul M., Long-term behavioral and neuroendocrine adaptations to adverse early experience, in The Biological Basis for Mind Body Interactions, 122, 2000. Crossref

  3. Klein Pave1, Herzog Andrew G., Hormonal Effects on Epilepsy in Women, Epilepsia, 39, s8, 1998. Crossref

  4. Donner Nina C., Lowry Christopher A., Sex differences in anxiety and emotional behavior, Pflügers Archiv - European Journal of Physiology, 465, 5, 2013. Crossref

  5. Burghardt Paul R, Wilson Marlene A, Microinjection of Naltrexone into the Central, but not the Basolateral, Amygdala Blocks the Anxiolytic Effects of Diazepam in the Plus Maze, Neuropsychopharmacology, 31, 6, 2006. Crossref

  6. Clark Ann, Henderson Leslie, Yang Paul, Jones Brian, Anabolic Androgenic Steroids and the Brain, in Neurosteroid Effects in the Central Nervous System, 20035180, 2003. Crossref

  7. De Jesús-Burgos María, Torres-Llenza Vanessa, Pérez-Acevedo Nivia L., Activation of amygdalar metabotropic glutamate receptors modulates anxiety, and risk assessment behaviors in ovariectomized estradiol-treated female rats, Pharmacology Biochemistry and Behavior, 101, 3, 2012. Crossref

  8. Cha Young May, Jones Katherine H., Kuhn Cynthia M., Wilson Wilkie A., Swartzwelder Harry Scott, Sex differences in the effects of Δ9-tetrahydrocannabinol on spatial learning in adolescent and adult rats, Behavioural Pharmacology, 18, 5-6, 2007. Crossref

  9. Henderson Leslie P., Jorge Juan Carlos, Steroid modulation of GABAA receptors:from molecular mechanisms to CNS roles in reproduction, dysfunction and drug abuse, in Molecular Insights into Ion Channel Biology in Health and Disease, 32, 2004. Crossref

  10. Ludwig Michael, Diedrich Klaus, Evaluation of an optimal luteal phase support protocol in IVF, Acta Obstetricia et Gynecologica Scandinavica, 80, 5, 2001. Crossref

  11. Frye Cheryl A., Walf Alicia A., Progesterone reduces depression-like behavior in a murine model of Alzheimer’s Disease, AGE, 31, 2, 2009. Crossref

  12. Teodorov E., Camarini R., Bernardi M.M., Felicio L.F., Treatment with steroid hormones and morphine alters general activity, sexual behavior, and opioid gene expression in female rats, Life Sciences, 104, 1-2, 2014. Crossref

  13. Liley David T. J., Cadusch Peter J., Gray Marcus, Nathan Pradeep J., Drug-induced modification of the system properties associated with spontaneous human electroencephalographic activity, Physical Review E, 68, 5, 2003. Crossref

  14. Penatti C.A.A., Porter D.M., Jones B.L., Henderson L.P., Sex-specific effects of chronic anabolic androgenic steroid treatment on GABAA receptor expression and function in adolescent mice, Neuroscience, 135, 2, 2005. Crossref

  15. Williams B., Bence M., Everest H., Forrest-Owen W., Lightman S. L., McArdle C. A., GABAA Receptor Mediated Elevation of Ca2+ and Modulation of Gonadotrophin-Releasing Hormone Action in αT3-1 Gonadotropes, Journal of Neuroendocrinology, 12, 2, 2001. Crossref

  16. Klein Pavel, Herzog Andrew, Emerging applications of hormonal therapy of paroxysmal central nervous system disorders, Expert Opinion on Investigational Drugs, 6, 10, 1997. Crossref

  17. WEAVER IAN C.G., DIORIO JOSIE, SECKL JONATHAN R., SZYF MOSHE, MEANEY MICHAEL J., Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression: Characterization of Intracellular Mediators and Potential Genomic Target Sites, Annals of the New York Academy of Sciences, 1024, 1, 2004. Crossref

  18. Frye C. A., Sumida K., Dudek B. C., Harney J. P., Lydon J. P., O’Malley B. W., Pfaff D. W., Rhodes M. E., Progesterone’s effects to reduce anxiety behavior of aged mice do not require actions via intracellular progestin receptors, Psychopharmacology, 186, 3, 2006. Crossref

  19. Cooper William A., Ross Karen C., Coleman James R, Estrogen Treatment and Age Effects on Auditory Brainstem Responses in the Post-breeding Long-Evans Rat, International Journal of Audiology, 38, 1, 1999. Crossref

  20. Harburger L.L., Saadi A., Frick K.M., Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal extracellular signal-regulated kinase activation in young ovariectomized mice, Neuroscience, 160, 1, 2009. Crossref

  21. Wilson Marlene A, Frye Cheryl A, Effects of chronic benzodiazepine exposure on stress-induced neuroactive steroid levels, Brain Research, 824, 1, 1999. Crossref

  22. Casasola C, Bargas J, Arias-Montaño J.-A, Calixto E, Montiel T, Galarraga E, Brailowsky S, Hippocampal hyperexcitability induced by GABA withdrawal is due to down-regulation of GABAA receptors, Epilepsy Research, 47, 3, 2001. Crossref

  23. Harris R.Adron, Mihic S.John, Valenzuela C.Fernando, Alcohol and benzodiazepines: recent mechanistic studies1Supported by funds from the NIH (NIAAA) and the Department of Veterans Affairs.1, Drug and Alcohol Dependence, 51, 1-2, 1998. Crossref

  24. Kellogg Carol K, Sex Differences in Long-Term Consequences of Prenatal Diazepam Exposure, Pharmacology Biochemistry and Behavior, 64, 4, 1999. Crossref

  25. Wilson Marlene A, Burghardt Paul R, Ford Kris A, Wilkinson Matthew B, Primeaux Stefany D, Anxiolytic effects of diazepam and ethanol in two behavioral models: comparison of males and females, Pharmacology Biochemistry and Behavior, 78, 3, 2004. Crossref

  26. Frye Cheryl A, Muscatiello Neil A, 3α,5α-THP in the raphe magnus attenuates PTZ-induced myoclonic seizures, Brain Research, 911, 2, 2001. Crossref

  27. Wilson Marlene A., Biscardi Rosemary, Influence of gender and brain region on neurosteroid modulation of GABA responses in rats, Life Sciences, 60, 19, 1997. Crossref

  28. Brinton Roberta Diaz, Thompson Richard F., Foy Michael R., Baudry Michel, Wang JunMing, Finch Caleb E., Morgan Todd E., Pike Christian J., Mack Wendy J., Stanczyk Frank Z., Nilsen Jon, Progesterone receptors: Form and function in brain, Frontiers in Neuroendocrinology, 29, 2, 2008. Crossref

  29. Smith M.D, Jones L.S, Wilson M.A, Sex differences in hippocampal slice excitability: role of testosterone, Neuroscience, 109, 3, 2002. Crossref

  30. Sadeghipour Hamid Reza, Ghasemi Mehdi, Sadeghipour Hamed, Riazi Kiarash, Soufiabadi Mohammad, Fallahi Nasrin, Dehpour Ahmad Reza, Nitric oxide involvement in estrous cycle-dependent changes of the behavioral responses of female rats in the elevated plus-maze test, Behavioural Brain Research, 178, 1, 2007. Crossref

  31. Stock Howard S, Hand Gregory A, Ford Kris, Wilson Marlene A, Changes in defensive behaviors following olfactory bulbectomy in male and female rats, Brain Research, 903, 1-2, 2001. Crossref

  32. Frye Cheryl A, Walf Alicia A, Sumida Kanako, Progestins' actions in the VTA to facilitate lordosis involve dopamine-like type 1 and 2 receptors, Pharmacology Biochemistry and Behavior, 78, 3, 2004. Crossref

  33. Kaufman Joan, Plotsky Paul M, Nemeroff Charles B, Charney Dennis S, Effects of early adverse experiences on brain structure and function: clinical implications, Biological Psychiatry, 48, 8, 2000. Crossref

  34. Wang Gang, Drake Carrie T., Rozenblit Mariya, Zhou Ping, Alves Stephen E., Herrick Scott P., Hayashi Shinji, Warrier Sudha, Iadecola Costantino, Milner Teresa A., Evidence that estrogen directly and indirectly modulates C1 adrenergic bulbospinal neurons in the rostral ventrolateral medulla, Brain Research, 1094, 1, 2006. Crossref

  35. Shir Yoram, Ratner Alexander, Seltzer Ze'ev, Diet can modify autotomy behavior in rats following peripheral neurectomy, Neuroscience Letters, 236, 2, 1997. Crossref

  36. Licciardi Frederick L, Kwiatkowski Andrea, Noyes Nicole L, Berkeley Alan S, Krey Lewis L, Grifo Jamie A, Oral versus intramuscular progesterone for in vitro fertilization: a prospective randomized study, Fertility and Sterility, 71, 4, 1999. Crossref

  37. Clark Ann S, Henderson Leslie P, Behavioral and physiological responses to anabolic-androgenic steroids, Neuroscience & Biobehavioral Reviews, 27, 5, 2003. Crossref

  38. Inghilleri M, Conte A, Currà A, Frasca V, Lorenzano C, Berardelli A, Ovarian hormones and cortical excitability. An rTMS study in humans, Clinical Neurophysiology, 115, 5, 2004. Crossref

  39. Geffroy Nancy, Guédin Aurore, Dacquet Catherine, Lefebvre Philippe, Cell cycle regulation of breast cancer cells through estrogen-induced activities of ERK and Akt protein kinases, Molecular and Cellular Endocrinology, 237, 1-2, 2005. Crossref

  40. Francis Darlene D, Caldji Christian, Champagne Frances, Plotsky Paul M, Meaney Michael J, The role of corticotropin-releasing factor–norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress, Biological Psychiatry, 46, 9, 1999. Crossref

  41. Kelly Sandra J, Ostrowski Nancy L, Wilson Marlene A, Gender Differences in Brain and Behavior, Pharmacology Biochemistry and Behavior, 64, 4, 1999. Crossref

  42. Gibbs R.B, Effects of gonadal hormone replacement on measures of basal forebrain cholinergic function, Neuroscience, 101, 4, 2000. Crossref

  43. Frye C.A., Rhodes M.E., Petralia S.M., Walf A.A., Sumida K., Edinger K.L., 3α-hydroxy-5α-pregnan-20-one in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors, Neuroscience, 138, 3, 2006. Crossref

  44. Sandford John J, Argyropoulos Spilios V, Nutt David J, The psychobiology of anxiolytic drugs, Pharmacology & Therapeutics, 88, 3, 2000. Crossref

  45. Senior Carl, Lau Ann, Butler Michael J.R., The effects of the menstrual cycle on social decision making, International Journal of Psychophysiology, 63, 2, 2007. Crossref

  46. Frye Cheryl A., Walf Alicia A., Petralia Sandra M., In the ventral tegmental area, progestins have actions at D1 receptors for lordosis of hamsters and rats that involve GABAA receptors, Hormones and Behavior, 50, 2, 2006. Crossref

  47. Tan Meliha, Tanb Uner, Sex Difference in Susceptibility to Epileptic Seizures in Rats: Importance of Estrous Cycle, International Journal of Neuroscience, 108, 3-4, 2001. Crossref

  48. Nett Sholeen T., Jorge-Rivera Juan Carlos, Myers Margaret, Clark Ann S., Henderson Leslie P., Properties and Sex-Specific Differences of GABAA Receptors in Neurons Expressing γ1 Subunit mRNA in the Preoptic Area of the Rat, Journal of Neurophysiology, 81, 1, 1999. Crossref

  49. van Bodegom Miranda, Homberg Judith R., Henckens Marloes J. A. G., Modulation of the Hypothalamic-Pituitary-Adrenal Axis by Early Life Stress Exposure, Frontiers in Cellular Neuroscience, 11, 2017. Crossref

  50. Isoardi Nora A, Martijena Irene D, Carrer Hugo F, Molina Víctor A, Increased Fear Learning Coincides with Neuronal Dysinhibition and Facilitated LTP in the Basolateral Amygdala following Benzodiazepine Withdrawal in Rats, Neuropsychopharmacology, 29, 10, 2004. Crossref

  51. Unfer Vittorio, Casini Maria Luisa, Marelli Guido, Costabile Loredana, Gerli Sandro, Di Renzo Gian Carlo, Different routes of progesterone administration and polycystic ovary syndrome: A review of the literature, Gynecological Endocrinology, 21, 2, 2005. Crossref

  52. Zhao Yulong, Bijlsma Elisabeth Y., Verdouw Monika P., Groenink Lucianne, No effect of sex and estrous cycle on the fear potentiated startle response in rats, Behavioural Brain Research, 351, 2018. Crossref

  53. Walker Claire-Dominique, Welberg Leonie A.M., Plotsky Paul M., Glucocorticoids, Stress, and Development, in Hormones, Brain and Behavior, 2002. Crossref

  54. Базян А. С., РОЛЬ ПОДКРЕПЛЕНИЯ ПРИ ОБУЧЕНИИ И ПАМЯТИ: КОДИРОВАНИЕ ЭМОЦИОНАЛЬНЫХ И МОТИВАЦИОННЫХ СОСТОЯНИЙ, ФУНКЦИИ МЕДИАТОРНЫХ И МОДУЛЯТОРНЫХ СИСТЕМ МОЗГА, "Успехи физиологических наук", Успехи физиологических наук, 3, 2018. Crossref

  55. Houshyar Shadi, Kaufman Joan, Resiliency in Maltreated Children, in Handbook of Resilience in Children, 2005. Crossref

  56. Houshyar Shadi, Gold Andrea, DeVries Melissa, Resiliency in Maltreated Children, in Handbook of Resilience in Children, 2013. Crossref

  57. Fitzgerald Morgan, Pritschet Laura, Santander Tyler, Grafton Scott T., Jacobs Emily G., Cerebellar network organization across the human menstrual cycle, Scientific Reports, 10, 1, 2020. Crossref

  58. Penza Kristin M., Heim Christine, Nemeroff Charles B., Loss and Deprivation: From Animal Models to Clinical Presentation, in Biology of Depression, 2005. Crossref

  59. Meaney Michael J, Maternal Care, Gene Expression, and the Transmission of Individual Differences in Stress Reactivity Across Generations, Annual Review of Neuroscience, 24, 1, 2001. Crossref

  60. Rybczynski Philip J., Combs Donald W., Jacobs Kimberly, Shank Richard P., Dubinsky Barry, γ-Aminobutyrate-A Receptor Modulation by 3-Aryl-1-(arylsulfonyl)- 1,4,5,6-tetrahydropyridazines, Journal of Medicinal Chemistry, 42, 13, 1999. Crossref

  61. Pinna Graziano, Costa Erminio, Guidotti Alessandro, Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior, Proceedings of the National Academy of Sciences, 102, 6, 2005. Crossref

  62. Benes Francine M., Lim Benjamin, Matzilevich David, Walsh John P., Subburaju Sivan, Minns Martin, Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars, Proceedings of the National Academy of Sciences, 104, 24, 2007. Crossref

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