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Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Resveratrol Alleviates Cadmium-Induced Damage and Overexpression of Epidermal Growth Factor Receptor and its Downstream Signaling Proteins in the Reproductive System of Male Swiss Albino Mice

Volume 35, Numéro 1, 2016, pp. 73-90
DOI: 10.1615/JEnvironPatholToxicolOncol.2016015298
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RÉSUMÉ

Nowadays, exposure to heavy metals and their detrimental effects in humans are grave health concerns. In this study, we investigated the protective effect of resveratrol (RES) against CdCl2 (cadmium chloride)-induced impairment of spermatogenesis, histopathological alterations, and the up-regulation of epidermal growth factor receptor (EGFR) signaling cascade in Swiss albino mice. Two different doses of CdCl2 were injected intraperitoneally into two groups of mice, and in the third group RES was administered orally before injecting CdCl2 (3 times/wk) for 14 days. Sperm motility, count, vitality, and morphology were analyzed. Hematoxylin and eosin (H&E) staining, immunohistochemistry (IHC), and western blot analyses were performed on testis tissue. In CdCl2-administered animals, significant perturbations of spermatogenesis and histoarchitecture of seminiferous tubules were observed. p-EGFR, p-AKT, AKT1/2/3, NF-κβ (p50), and COX-2 of the EGFR cascade were up-regulated. Although there was significant negative correlation between percentage of motile cells and protein expression, we found positive correlation between morphologically abnormal cells and overexpression of proteins in CdCl2-only treated groups. Marked improvement of sperm parameters and histopathological damages as well as down-regulation of the EGFR signaling cascade were observed in the RES-pretreated mice. Hence, the present study elucidates that RES protects against CdCl2-induced perturbation of spermatogenesis and overexpression of EGFR and its downstream signaling proteins.

CITÉ PAR
  1. Rauf Abdur, Imran Muhammad, Suleria Hafiz Ansar Rasul, Ahmad Bashir, Peters Dennis G., Mubarak Mohammad S., A comprehensive review of the health perspectives of resveratrol, Food & Function, 8, 12, 2017. Crossref

  2. Fu Beibei, Zhao Jiamin, Peng Wei, Wu Haibo, Zhang Yong, Resveratrol rescues cadmium-induced mitochondrial injury by enhancing transcriptional regulation of PGC-1α and SOD2 via the Sirt3/FoxO3a pathway in TCMK-1 cells, Biochemical and Biophysical Research Communications, 486, 1, 2017. Crossref

  3. De Paepe Boel, Van Coster Rudy, A Critical Assessment of the Therapeutic Potential of Resveratrol Supplements for Treating Mitochondrial Disorders, Nutrients, 9, 9, 2017. Crossref

  4. Fouad Amr A., Abdel-Aziz Asmaa M., Hamouda Azza A. H., Diacerein Downregulates NLRP3/Caspase-1/IL-1β and IL-6/STAT3 Pathways of Inflammation and Apoptosis in a Rat Model of Cadmium Testicular Toxicity, Biological Trace Element Research, 195, 2, 2020. Crossref

  5. Wang Susu, Ren Xiangmei, Hu Xindi, Zhou Li, Zhang Chaoqin, Zhang Meirong, Cadmium-induced apoptosis through reactive oxygen species-mediated mitochondrial oxidative stress and the JNK signaling pathway in TM3 cells, a model of mouse Leydig cells, Toxicology and Applied Pharmacology, 368, 2019. Crossref

  6. Bhardwaj Jitender Kumar, Panchal Harish, Saraf Priyanka, Cadmium as a testicular toxicant: A Review, Journal of Applied Toxicology, 41, 1, 2021. Crossref

  7. Ren Xiangmei, Wang Susu, Zhang Chaoqin, Hu Xindi, Zhou Li, Li Yuanhong, Xu Lichun, Selenium ameliorates cadmium-induced mouse leydig TM3 cell apoptosis via inhibiting the ROS/JNK /c-jun signaling pathway, Ecotoxicology and Environmental Safety, 192, 2020. Crossref

  8. Yi Lingna, Dai Juan, Chen Yong, Tong Yeqing, Li You, Fu Guoqing, Teng Zengguang, Huang Jufeng, Quan Chao, Zhang Zhibing, Zhou Ting, Zhang Ling, Shi Yuqin, Reproductive toxicity of cadmium in pubertal male rats induced by cell apoptosis, Toxicology and Industrial Health, 37, 8, 2021. Crossref

  9. Li Siqiang, Li Yun, Chen Fujia, Yang Yurong, Song Li, Liu Chaoying, Wang Baogen, Xu Yuanhong, Shao Mingguang, Li Enzhong, Metabolomics analysis reveals metabolic changes associated with trans-resveratrol treatment in experimental cryptorchidism mice, Reproduction, Fertility and Development, 33, 5, 2021. Crossref

  10. Bhardwaj Jitender Kumar, Panchal Harish, Quercetin mediated attenuation of cadmium‐induced oxidative toxicity and apoptosis of spermatogenic cells in caprine testes in vitro, Environmental and Molecular Mutagenesis, 62, 6, 2021. Crossref

  11. Ferlazzo Nadia, Micali Antonio, Marini Herbert Ryan, Freni Josè, Santoro Giuseppe, Puzzolo Domenico, Squadrito Francesco, Pallio Giovanni, Navarra Michele, Cirmi Santa, Minutoli Letteria, A Flavonoid-Rich Extract from Bergamot Juice, Alone or in Association with Curcumin and Resveratrol, Shows Protective Effects in a Murine Model of Cadmium-Induced Testicular Injury, Pharmaceuticals, 14, 5, 2021. Crossref

  12. Qian Yan, Wang Rui, Wei Wei, Wang Min, Wang Siying, Resveratrol reverses the cadmium-promoted migration, invasion, and epithelial–mesenchymal transition procession by regulating the expression of ZEB1, Human & Experimental Toxicology, 40, 12_suppl, 2021. Crossref

  13. Mitra Sreyashi, Patra Tapas, Saha Depanwita, Ghosh Paramita, Mustafi Saunak Mitra, Varghese Alex C., Murmu Nabendu, Sub‐chronic cadmium and lead compound exposure induces reproductive toxicity and development of testicular germ cell neoplasia in situ in murine model: Attenuative effects of resveratrol, Journal of Biochemical and Molecular Toxicology, 36, 7, 2022. Crossref

  14. Ikokide Emmanuel Joseph, Oyagbemi Ademola Adetokunbo, Oyeyemi Matthew Olugbenga, Impacts of cadmium on male fertility: Lessons learnt so far, Andrologia, 54, 9, 2022. Crossref

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