Abonnement à la biblothèque: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Accéder(open in a new tab)
Suite
Achat $30.00(open in a new tab) Vérifier l'abonnement Télécharger l'archive MARC(open in a new tab) Obtenir des autorisations(open in a new tab)

Genistein Induces Cytochrome P450 1B1 Gene Expression and Cell Proliferation in Human Breast Cancer MCF-7 Cells

Volume 34, Numéro 2, 2015, pp. 153-159
DOI: 10.1615/JEnvironPatholToxicolOncol.2015013315
Get accessGet access
Yinan K. Wei
Mercer University School of Medicine, Macon, Georgia; The University of Georgia, Athens, Georgia, USA
Irene Gamra
Mercer University School of Medicine, Macon, Georgia, USA
Andrew Davenport
Mercer University School of Medicine, Macon, Georgia, USA
Richard Lester
Mercer University School of Medicine, Macon, Georgia, USA
Lijun Zhao
Mercer University School of Medicine, Macon, Georgia, USA; Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China
Yudan Wei
Mercer University School of Medicine

RÉSUMÉ

Cytochrome P450 1B1 (CYP1B1) plays an important role in breast cancer development and progression by bioactivating endogenous estrogens and environmental carcinogens. In this study, we examined the effect of the soy isoflavone genistein on CYP1B1 gene expression, reactive oxygen species (ROS) production, and cell proliferation in human breast cancer MCF-7 cells. Real-time reverse transcription polymerase chain reaction (RT-PCR) analysis showed a dose-dependent induction of CYP1B1 gene expression in the cells treated with 5 and 25 μM of genistein. Genistein at 5 μM exhibited a synergistic effect on the CYP1B1 mRNA level induced by the environmental carcinogen 7,12-dimethylbenz[a]anthracene. We also found that genistein at 5 μM increased cellular levels of ROS and stimulated cell proliferation starting from the second day of culture. This study suggests that physiological concentrations of genistein stimulate ROS production and breast cancer cell proliferation through the induction of CYP1B1 gene expression. More extensive studies are warranted to further characterize the role of genistein and the CYP1B1 enzyme in human breast carcinogenesis.

MOTS CLÉS: genistein, breast cancer, cytochrome P450 1B1, MCF-7, cell proliferation, ROS
CITÉ PAR

  1. Sashi Papu John A. M., Ankem Murali K., Damodaran Chendil, Oxidative Stress: a Promising Target for Chemoprevention, Current Pharmacology Reports, 2, 2, 2016. Crossref

  2. Ronis Martin J. J., Effects of soy containing diet and isoflavones on cytochrome P450 enzyme expression and activity, Drug Metabolism Reviews, 48, 3, 2016. Crossref

  3. Dietz Birgit M., Hajirahimkhan Atieh, Dunlap Tareisha L., Bolton Judy L., Barker Eric, Botanicals and Their Bioactive Phytochemicals for Women’s Health, Pharmacological Reviews, 68, 4, 2016. Crossref

  4. Poschner Stefan, Maier-Salamon Alexandra, Zehl Martin, Wackerlig Judith, Dobusch Daniel, Pachmann Bettina, Sterlini Konstantin L., Jäger Walter, The Impacts of Genistein and Daidzein on Estrogen Conjugations in Human Breast Cancer Cells: A Targeted Metabolomics Approach, Frontiers in Pharmacology, 8, 2017. Crossref

  5. Li Ya, Li Sha, Meng Xiao, Gan Ren-You, Zhang Jiao-Jiao, Li Hua-Bin, Dietary Natural Products for Prevention and Treatment of Breast Cancer, Nutrients, 9, 7, 2017. Crossref

  6. Yasuda Michiko T., Sakakibara Hiroyuki, Shimoi Kayoko, Estrogen- and stress-induced DNA damage in breast cancer and chemoprevention with dietary flavonoid, Genes and Environment, 39, 1, 2017. Crossref

  7. Hu Chengshen, Wong Wing-Tak, Wu Runyu, Lai Wing-Fu, Biochemistry and use of soybean isoflavones in functional food development, Critical Reviews in Food Science and Nutrition, 60, 12, 2020. Crossref

  8. Piccolella Margherita, Crippa Valeria, Cristofani Riccardo, Rusmini Paola, Galbiati Mariarita, Cicardi Maria Elena, Meroni Marco, Ferri Nicola, Morelli Federica F., Carra Serena, Messi Elio, Poletti Angelo, The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells, Oncotarget, 8, 6, 2017. Crossref

  9. Lee Yongkyu, Lee Jehyung, Lim Changbaek, Anticancer activity of flavonoids accompanied by redox state modulation and the potential for a chemotherapeutic strategy, Food Science and Biotechnology, 30, 3, 2021. Crossref

  10. Bhat Smitha S., Prasad Shashanka K., Shivamallu Chandan, Prasad Kollur Shiva, Syed Asad, Reddy Pruthvish, Cull Charley A., Amachawadi Raghavendra G., Genistein: A Potent Anti-Breast Cancer Agent, Current Issues in Molecular Biology, 43, 3, 2021. Crossref

  11. Carrera Alexa N., Grant Marianne K.O., Zordoky Beshay N., CYP1B1 as a therapeutic target in cardio-oncology, Clinical Science, 134, 21, 2020. Crossref

  12. Sharifi-Rad Javad, Quispe Cristina, Imran Muhammad, Rauf Abdur, Nadeem Muhammad, Gondal Tanweer Aslam, Ahmad Bashir, Atif Muhammad, Mubarak Mohammad S., Sytar Oksana, Zhilina Oxana Mihailovna, Garsiya Ekaterina Robertovna, Smeriglio Antonella, Trombetta Domenico, Pons Daniel Gabriel, Martorell Miquel, Cardoso Susana M., Razis Ahmad Faizal Abdull, Sunusi Usman, Kamal Ramla Muhammad, Rotariu Lia Sanda, Butnariu Monica, Docea Anca Oana, Calina Daniela, Toan Sam, Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits, Oxidative Medicine and Cellular Longevity, 2021, 2021. Crossref

  13. Bhardwaj Priti, Kumar Manoj, Dhatwalia Sunil Kumar, Garg Mohan Lal, Dhawan Devinder Kumar, Protective role of AKBA against benzo(a)pyrene‐induced lung carcinogenesis by modulating biotransformation enzymes and oxidative stress, Journal of Biochemical and Molecular Toxicology, 36, 7, 2022. Crossref

  14. Grgic Dino, Betschler Andrea, Früholz Rebeka, Novak Barbara, Varga Elisabeth, Marko Doris, Estrogenic in vitro evaluation of zearalenone and its phase I and II metabolites in combination with soy isoflavones, Archives of Toxicology, 2022. Crossref

1085 Vues d'articles 78 Téléchargements d'articles Métrique
1085 VUES 78 TÉLÉCHARGEMENTS 14 Crossref CITATIONS Google
Scholar CITATIONS

Articles avec un contenu similaire:

Luteolin Induces Cell Cycle Arrest and Apoptosis Through Extrinsic and Intrinsic Signaling Pathways in MCF-7 Breast Cancer Cells Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 3
Su-Ho Park, Jeoung-Woo Kang, Sunyoung Ham, Sei-Ryang Oh, Tae Ho Kwon, Do-Young Yoon, Man Sub Kim, Dong Hun Lee
Effect of Polysaccharides and 70% Ethanol Extracts from Medicinal Mushrooms on Growth of Human Prostate Cancer LNCaP and PC-3 Cells International Journal of Medicinal Mushrooms, Vol.12, 2010, issue 2
Tadashi Kiho, Kazuhiro Iguchi, Kazuyuki Hirano, Shigeyuki Usui
Autophagy Inhibition Enhances SPCA-1 Cell Proliferation Inhibition Induced by By-1 from the Stout Camphor Medicinal Mushroom, Taiwanofungus camphoratus (Agaricomycetes) International Journal of Medicinal Mushrooms, Vol.20, 2018, issue 4
Di Wu, Wenbo Sun, Yanfang Liu, Yaping Zhang, Yan Yang, Li Min, Hairui Yang, Zheng Qiankun, Wei Jia, Wenhan Wang, Jinsong Zhang
Neurotrophic Properties of the Lion's Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia International Journal of Medicinal Mushrooms, Vol.15, 2013, issue 6
Sri Nurestri Abdul Malek, Kah-Hui Wong, Puei-Lene Lai, Noorlidah Abdullah, Umah Rani Kuppusamy, Murali Naidu, Rosie Pamela David, Vikineswary Sabaratnam
Radical Scavenging and Antiproliferative Effects of Cordycepin-Rich Ethanol Extract from Brown Rice−Cultivated Cordyceps militaris (Ascomycetes) Mycelium on Breast Cancer Cell Lines International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 7
Yao-Chung Wu, Jui-Chih Chang, Huei-Shin Chang, Chin-San Liu, Ting-Yung Hsu, Zeng-Chin Liang, Shou-Tung Chen, Han-Chiang Wu, Chi-Chia Cheng

Dernier numéro

A Review on Protease Inhibitors of Herbal Origin to Combat Malignancy Sanjib Bhattacharya Molecular Pathogenesis, Organ Metastasis, and Targeted Therapy for Non-Small-Cell Lung Cancer Salik Abdullah, Ratul Chakraborty, Pratiksha Somnath Kumkar, Biplab Debnath, Asis Bala Treatment Strategy for Breast Benign Intraductal Papilloma: A Meta-Analysis Congkun Lou, Wenhsin Wang, Binggang Zhou Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma Shijing Tang, Hao Chen RNF20 Reduces Cell Proliferation and Warburg Effect by Promoting NLRP3 Ubiquitination in Liver Cancer Deqin Liu, Renyin Luo, Qian Zhou, Mei Li Development of a Prognostic Model for Gastric Cancer Based on Apoptosis- and Hypoxia-Related Genes: Predictive Insights into Survival and Immune Landscape Jian Zhu, Yao Ma

Prochains articles

LncRNA LINC01278 regulates the prognosis and related mechanisms of gastric cancer by targeting miR-129-5p Zhenhua Wang, Zhengliang Li, Xiaojing Liu, Jundong Wang, Jiaxi Wang, Guoxiang Jiang, Haizhou Yu FBXO45 expression levels Correlation with cancer severity by ZEB1 ubiquitin in non-small cell lung cancer Bingwei Dong LncRNA AGAP11 suppresses lung adenocarcinoma progression by miR-494-3p and predicts prognosis Ye He, Ya Lin , Chunge Dong, Jie Zhang, Yangli Zhu Treatment strategy for breast benign intraductal papilloma: A Meta-Analysis Congkun Lou, Wenxin Wang, Binggang Zhou Prognostic Significance of Iron Metabolism and Immune-Related Genes as Risk Markers in Hepatocellular Carcinoma Shijing Tang, Hao Chen Molecular Pathogenesis, Organ Metastasis, and Targeted Therapy for Non-Small Cell Lung Cancer (NSCLC) Salik Abdullah, Ratul Chakraborty, Pratiksha Somnath Kumkar, Biplab Debnath, Asis Bala A review on protease inhibitors of herbal origin to combat malignancy Sanjib Bhattacharya
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections Prix et politiques d'abonnement Begell House Contactez-nous Language English 中文 Русский Português German French Spain