Publication de 4 numéros par an
ISSN Imprimer: 0731-8898
ISSN En ligne: 2162-6537
Indexed in
Is It a Protective Factor of Helicobacter pylori Infection in Overall Survival of All Gastric Cancer? Evidence from Meta-Analysis
RÉSUMÉ
Purpose – We aimed to assess whether Helicobacter pylori infection influences prognosis in gastric cancer patients (GC).
Methods – We systematically searched MEDLINE, PubMed, EBSCO, EMBASE, and the Cochrane Library (CENTRAL) Register from inception to June 1, 2017. Overall survival (mean OS) or disease-free survival (mean DFS) in GC patients were calculated using the hazard ratio (HR) and 95% confidence intervals (95% CIs).
Results – In total, 19 articles with 4,321 GC patients were enrolled. Helicobacter pylori infection is associated with longer OS (HR 0.73; 95% CI 0.60–0.89; P < 0.001) and DFS (HR 0.75; 95% CI 0.53–1.07; P = 0.002) in GC patients overall. For our subgroup analysis, the pooled HRs and 95% CIs were as follows: China (OS: HR 0.95; 95% CI 0.63–1.42; P = 0.804 and DFS: HR 0.88; 95% CI 0.50–1.56; P = 0.658), Europe (OS: HR 0.69; 95% CI 0.52–0.92; P = 0.010 and DFS: HR 0.62; 95% CI 0.32–1.17; P = 0.141), United States (OS: HR 0.77: 95% CI 0.56–1.06; P = 0.105), Korea (OS: HR 0.45; 95% CI 0.27–0.75; P = 0.002 and DFS: HR 0.45; 95% CI 0.24–0.83, P = 0.011), and Turkey (OS: HR 0.94; 95% CI 0.52–1.70; P = 0.839 and DFS: HR 0.95; 95% CI 0.53–1.71, P = 0.864). Moreover, for R0 or M0 patients, H. pylori infection is associated with better OS and DFS (P all values < 0.05).
Conclusions – Helicobacter pylori infection has a better prognosis in GC patients from Korea and Europe. Helicobacter pylori infection has no association with prognosis for China, the United States, or Turkey. Also, H. pylori infection has a better prognosis in R0 resection or M0 GC patients.
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Chuang Yun‐Shiuan, Wu Meng‐Chieh, Wang Yao‐Kuang, Chen Yi‐Hsun, Kuo Chao‐Hung, Wu Deng‐Chyang, Wu Ming‐Tsang, Wu I‐Chen, Risks of substance uses, alcohol flush response, Helicobacter pylori infection and upper digestive tract diseases—An endoscopy cross‐sectional study , The Kaohsiung Journal of Medical Sciences, 2019. Crossref
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