Abonnement à la biblothèque: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Publication de 4  numéros par an

ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Amelioration of Doxorubicin-Induced Cardiac and Renal Toxicity by Oxycarotenoid Lutein and Its Mechanism of Action

Volume 35, Numéro 3, 2016, pp. 237-247
DOI: 10.1615/JEnvironPatholToxicolOncol.2016014010
Get accessGet access

RÉSUMÉ

We set out to determine the effect of oxycarotenoid lutein on reducing cardiac and renal toxicity induced by doxorubicin (DXR). We started with oral administration in rats of lutein for 15 d before administering DXR (30 mg/kg body weight, intraperitoneally, in a single dose). Animals in all groups were sacrificed 24 h after DXR administration. Serum markers of cardiac injury lactate dehydrogenase, creatine phosphokinase, serum glutamate oxaloacetate transaminase, and serum glutamate pyruvate transaminase increased drastically after DXR but decreased after lutein treatment (p < 0.001). Elevated serum urea and creatinine in DXR-treated rats were reduced by lutein treatment (p < 0.001). Lutein increased superoxide dismutase, catalase, glutathione peroxidase, and glutathione levels in cardiac and renal tissues of DXR-treated rats. Pretreatment of lutein reduced DXR-induced rise of oxidative stress markers including lipid peroxidation, tissue hydroperoxides, and conjugated dienes in cardiac and renal tissue. These findings were supported by electrocardiogram measurements and histopathological analyses. Results confirmed the protection of lutein against cardiac and renal toxicity induced by DXR in rats.

CITÉ PAR
  1. Augusti Paula Rossini, Brasil Allana Von Sulzback, Souto Caroline, Göethel Gabriela, de Oliveira Rios Alessandro, Emanuelli Tatiana, Bürger Marilise Escobar, Garcia Solange Cristina, Microcystin-LR exposure induces oxidative damage in Caenorhabditis elegans : Protective effect of lutein extracted from marigold flowers, Food and Chemical Toxicology, 109, 2017. Crossref

  2. Xiang Chengyu, Yan Yi, Zhang Dingguo, Alleviation of the doxorubicin-induced nephrotoxicity by fasudil in vivo and in vitro, Journal of Pharmacological Sciences, 145, 1, 2021. Crossref

  3. Saleh Dalia, Abdelbaset Marawan, Hassan Azza, Sharaf Ola, Mahmoud Sawsan, Hegazy Rehab, Mukhopadhyay Partha, Omega-3 fatty acids ameliorate doxorubicin-induced cardiorenal toxicity: In-vivo regulation of oxidative stress, apoptosis and renal Nox4, and in-vitro preservation of the cytotoxic efficacy, PLOS ONE, 15, 11, 2020. Crossref

  4. Hussain Mona A., Abogresha Noha M., AbdelKader Ghada, Hassan Ranya, Abdelaziz Eman Z., Greish Sahar M., Morroni Fabiana, Antioxidant and Anti-Inflammatory Effects of Crocin Ameliorate Doxorubicin-Induced Nephrotoxicity in Rats, Oxidative Medicine and Cellular Longevity, 2021, 2021. Crossref

  5. Różanowska Małgorzata B., Czuba-Pelech Barbara, Landrum John T., Różanowski Bartosz, Comparison of Antioxidant Properties of Dehydrolutein with Lutein and Zeaxanthin, and their Effects on Cultured Retinal Pigment Epithelial Cells, Antioxidants, 10, 5, 2021. Crossref

  6. Xing Wen, Wen Chaoling, Wang Deguo, Shao Hui, Liu Chunhong, He Chunling, Olatunji Opeyemi Joshua, Cardiorenal Protective Effect of Costunolide against Doxorubicin-Induced Toxicity in Rats by Modulating Oxidative Stress, Inflammation and Apoptosis, Molecules, 27, 7, 2022. Crossref

Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections Prix et politiques d'abonnement Begell House Contactez-nous Language English 中文 Русский Português German French Spain