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Journal of Environmental Pathology, Toxicology and Oncology

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ISSN Imprimer: 0731-8898

ISSN En ligne: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Antioxidative Effects of Schidandrin B and Green Tea Polyphenols Against Mercuric Chloride-Induced Hepatotoxicity in rats

Volume 33, Numéro 4, 2014, pp. 349-361
DOI: 10.1615/JEnvironPatholToxicolOncol.2014011859
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Yu Deng
Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001
Zhaofa Xu
Department of Environmental Health, School of Public Health, China Medical University
Bin Xu
Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001
Wei Liu
Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001
Shu Feng
Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001
Tianyao Yang
Department of Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning 110001

RÉSUMÉ

In the present study, we investigated the hepatoprotective effects of schisandrin B (Sch B) and green tea polyphenols (GrTP), two natural antioxidants, against Hg hepatotoxicity. Fifty-six rats were randomly divided into four groups of fourteen animals in each group: control group, Hg-treated group, Sch B pretreated group, and GrTP pretreated group. HgCl2 injection increased Hg accumulation, pathological and ultrastructural injury, lactate dehydrogenase (LDH) level, alanine transaminase (ALT) level, apoptosis, reactive oxygen species (ROS) level, glutathione (GSH) level, and malondialdehyde (MDA) level. HgCl2 injection decreased glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities. Sch B and GrTP protected against Hg-induced dysfunction and liver injury by enhancing the antioxidant defense system. Our results indicate that Sch B and GrTP exert antioxidative effects against Hg-induced hepatotoxicity in rats.

MOTS CLÉS: Mercury, schisandrin B, green tea polyphenols, hepatotoxicity, oxidative stress
CITÉ PAR

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  2. Rameshrad Maryam, Razavi Bibi Marjan, Hosseinzadeh Hossein, Protective effects of green tea and its main constituents against natural and chemical toxins: A comprehensive review, Food and Chemical Toxicology, 100, 2017. Crossref

  3. Samarghandian Saeed, Azimi-Nezhad Mohsen, Farkhondeh Tahereh, Catechin Treatment Ameliorates Diabetes and Its Complications in Streptozotocin-Induced Diabetic Rats, Dose-Response, 15, 1, 2017. Crossref

  4. Ansar S, Iqbal M, Protective effect of diallylsulphide against mercuric chloride-induced hepatic injury in rats, Human & Experimental Toxicology, 35, 12, 2016. Crossref

  5. Wang Dongxu, Zhang Man, Wang Taotao, Cai Min, Qian Frank, Sun Yue, Wang Yijun, Green tea polyphenols prevent lipopolysaccharide-induced inflammatory liver injury in mice by inhibiting NLRP3 inflammasome activation, Food & Function, 10, 7, 2019. Crossref

  6. Nasser M. I., Zhu Shuoji, Chen Chen, Zhao Mingyi, Huang Huanlei, Zhu Ping, A Comprehensive Review on Schisandrin B and Its Biological Properties, Oxidative Medicine and Cellular Longevity, 2020, 2020. Crossref

  7. Wang Jia, Fang Zhong, Song Chao, Kang Honglei, Guo Qian, Dong Yimin, Zhang Ya, Peng Renpeng, Guan Hanfeng, Li Feng, Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss, Frontiers in Pharmacology, 11, 2020. Crossref

  8. Lee Hak Yeong, Nam Yoonjin, Choi Won Seok, Kim Tae Wook, Lee Jaehwi, Sohn Uy Dong, The hepato-protective effect of eupatilin on an alcoholic liver disease model of rats, The Korean Journal of Physiology & Pharmacology, 24, 5, 2020. Crossref

  9. Wang Dongxu, Zhang Man, Wang Taotao, Liu Tiantian, Guo Yuanxin, Granato Daniel, Green tea polyphenols mitigate the plant lectins-induced liver inflammation and immunological reaction in C57BL/6 mice via NLRP3 and Nrf2 signaling pathways, Food and Chemical Toxicology, 144, 2020. Crossref

  10. Shi Hongwei, Yan Yue, Yang Hong, Pu Peng, Tang Heng, Stanek Agata, Schisandrin B Diet Inhibits Oxidative Stress to Reduce Ferroptosis and Lipid Peroxidation to Prevent Pirarubicin-Induced Hepatotoxicity, BioMed Research International, 2022, 2022. Crossref

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