Publication de 6 numéros par an
ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472
Indexed in
Chlamydial Infection of Immune Cells: Altered Function and Implications for Disease
RÉSUMÉ
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that infects the genital and ocular mucosa of humans, causing infections that can lead to pelvic inflammatory disease, infertility, and blinding trachoma. C. pneumoniae is a respiratory pathogen that is the cause of 12−15% of community-acquired pneumonia. Both chlamydial species were believed to be restricted to the epithelia of the genital, ocular, and respiratory mucosa; however, increasing evidence suggests that both these pathogens can be isolated from peripheral blood of both healthy individuals and patients with inflammatory conditions such as coronary artery disease and asthma. Chlamydia can also be isolated from brain tissues of patients with degenerative neurological disorders such as Alzheimer's disease and multiple sclerosis, and also from certain lymphomas. An increasing number of in vitro studies suggest that some chlamydial species can infect immune cells, at least at low levels. These infections may alter immune cell function in a way that promotes chlamydial persistence in the host and contributes to the progression of several chronic inflammatory diseases. In this paper, we review the evidence for the growth of Chlamydia in immune cells, particularly monocytes/macrophages and dendritic cells, and describe how infection may affect the function of these cells.
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Hansbro Philip M, Scott Grace V, Essilfie Ama-Tawiah, Kim Richard Y, Starkey Malcolm R, Nguyen Duc H, Allen Paul D, Kaiko Gerard E, Yang Ming, Horvat Jay C, Foster Paul S, Th2 cytokine antagonists: potential treatments for severe asthma, Expert Opinion on Investigational Drugs, 22, 1, 2013. Crossref
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Starkey M R, Essilfie A T, Horvat J C, Kim R Y, Nguyen D H, Beagley K W, Mattes J, Foster P S, Hansbro P M, Constitutive production of IL-13 promotes early-life Chlamydia respiratory infection and allergic airway disease, Mucosal Immunology, 6, 3, 2013. Crossref
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Kapp Karmen, Hakala Elina, Orav Anne, Pohjala Leena, Vuorela Pia, Püssa Tõnu, Vuorela Heikki, Raal Ain, Commercial peppermint (Mentha×piperita L.) teas: Antichlamydial effect and polyphenolic composition, Food Research International, 53, 2, 2013. Crossref
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Hafner Louise M., Timms Peter, Chlamydia, in Sexually Transmitted Diseases, 2013. Crossref
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Mackern-Oberti Juan Pablo, Motrich Rubén Darío, Breser María Laura, Sánchez Leonardo Rodolfo, Cuffini Cecilia, Rivero Virginia Elena, Chlamydia trachomatis infection of the male genital tract: An update, Journal of Reproductive Immunology, 100, 1, 2013. Crossref
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Hafner Louise M., Wilson David P., Timms Peter, Development status and future prospects for a vaccine against Chlamydia trachomatis infection, Vaccine, 32, 14, 2014. Crossref
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Starkey M R, Nguyen D H, Essilfie A T, Kim R Y, Hatchwell L M, Collison A M, Yagita H, Foster P S, Horvat J C, Mattes J, Hansbro P M, Tumor necrosis factor-related apoptosis-inducing ligand translates neonatal respiratory infection into chronic lung disease, Mucosal Immunology, 7, 3, 2014. Crossref
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Karpińska Teresa, Kozaczyński Wojciech, Niemczuk Krzysztof, Jasik Agnieszka, Kycko Anna, Reichert Michał, Mixed infection by fowlpox virus and Chlamydophila psittaci in a commercial laying hen flock, Acta Veterinaria Hungarica, 62, 1, 2014. Crossref
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Al-Zeer Munir A., Al-Younes Hesham M., Lauster Daniel, Abu Lubad Mohammad, Meyer Thomas F., Autophagy restrictsChlamydia trachomatisgrowth in human macrophages via IFNG-inducible guanylate binding proteins, Autophagy, 9, 1, 2013. Crossref
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Hallstrand Teal S., Hackett Tillie L., Altemeier William A., Matute-Bello Gustavo, Hansbro Philip M., Knight Darryl A., Airway epithelial regulation of pulmonary immune homeostasis and inflammation, Clinical Immunology, 151, 1, 2014. Crossref
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Redgrove Kate A., McLaughlin Eileen A., The Role of the Immune Response in Chlamydia trachomatis Infection of the Male Genital Tract: A Double-Edged Sword, Frontiers in Immunology, 5, 2014. Crossref
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Entrican Gary, Wattegedera Sean, Wheelhouse Nick, Allan Alasdair, Rocchi Mara, Immunological Paradigms and the Pathogenesis of Ovine Chlamydial Abortion, American Journal of Reproductive Immunology, 64, 4, 2010. Crossref
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Marangoni Antonella, Bergamini Christian, Fato Romana, Cavallini Claudia, Donati Manuela, Nardini Paola, Foschi Claudio, Cevenini Roberto, Infection of human monocytes by Chlamydia pneumoniae and Chlamydia trachomatis: an in vitro comparative study, BMC Research Notes, 7, 1, 2014. Crossref
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Prakash Sangeetha, Agrawal Sudhanshu, Ma Dandan, Gupta Sudhir, Peterson Ellena M., Agrawal Anshu, Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses toChlamydophila pneumoniae, Mediators of Inflammation, 2014, 2014. Crossref
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Kebbi-Beghdadi Carole, Greub Gilbert, Importance of amoebae as a tool to isolate amoeba-resisting microorganisms and for their ecology and evolution: theChlamydiaparadigm, Environmental Microbiology Reports, 6, 4, 2014. Crossref
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Datta Baishakhi, Njau Florence, Thalmann Jessica, Haller Hermann, Wagner Annette D, Differential infection outcome of Chlamydia trachomatis in human blood monocytes and monocyte-derived dendritic cells, BMC Microbiology, 14, 1, 2014. Crossref
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Mackern Oberti J P, Breser M L, Nuñez N, Maccioni M, Rodríguez N, Wantia N, Ertl T, Miethke T, Rivero V E, Chemokine response induced by Chlamydia trachomatis in prostate derived CD45+ and CD45− cells, REPRODUCTION, 142, 3, 2011. Crossref
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Mannonen Laura, Markkula Eveliina, Puolakkainen Mirja, Analysis of Chlamydia pneumoniae infection in mononuclear cells by reverse transcription-PCR targeted to chlamydial gene transcripts, Medical Microbiology and Immunology, 200, 3, 2011. Crossref
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Armitage C. W., O'Meara C. P., Beagley K. W., Chlamydia pneumoniaeandChlamydia TrachomatisInfection Differentially Modulates Human Dendritic Cell Line (MUTZ) Differentiation and Activation, Scandinavian Journal of Immunology, 82, 1, 2015. Crossref
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Kokes Marcela, Dunn Joe Dan, Granek Joshua A., Nguyen Bidong D., Barker Jeffrey R., Valdivia Raphael H., Bastidas Robert J., Integrating Chemical Mutagenesis and Whole-Genome Sequencing as a Platform for Forward and Reverse Genetic Analysis of Chlamydia, Cell Host & Microbe, 17, 5, 2015. Crossref
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Chacko Anu, Beagley Kenneth W., Timms Peter, Huston Wilhelmina M., Human Chlamydia pneumoniae isolates demonstrate ability to recover infectivity following penicillin treatment whereas animal isolates do not, FEMS Microbiology Letters, 362, 6, 2015. Crossref
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Gracey Eric, Baglaenko Yuriy, Prayitno Nadia, Van Rooijen Nico, Akram Ali, Lin Aifeng, Chiu Basil, Inman Robert D., PulmonaryChlamydia muridarumchallenge activates lung interstitial macrophages which correlate with IFN-γ production and infection control in mice, European Journal of Immunology, 45, 12, 2015. Crossref
-
Azenabor Anthony A., Cintrón-Cuevas Jenniffer, Schmitt Heather, Bumah Violet, Chlamydia trachomatis induces anti-inflammatory effect in human macrophages by attenuation of immune mediators in Jurkat T-cells, Immunobiology, 216, 12, 2011. Crossref
-
Hansbro P. M., Starkey M. R., Kim R. Y., Stevens R. L., Foster P. S., Horvat J. C., Programming of the lung by early-life infection, Journal of Developmental Origins of Health and Disease, 3, 03, 2012. Crossref
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Murphy DM, Forrest IA, Curran D, Ward C, Macrolide antibiotics and the airway: antibiotic or non-antibiotic effects?, Expert Opinion on Investigational Drugs, 19, 3, 2010. Crossref
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Kim Richard Y, Rae Brittany, Neal Rachel, Donovan Chantal, Pinkerton James, Balachandran Lohis, Starkey Malcolm R, Knight Darryl A, Horvat Jay C, Hansbro Philip M, Elucidating novel disease mechanisms in severe asthma, Clinical & Translational Immunology, 5, 7, 2016. Crossref
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Herweg Jo-Ana, Rudel Thomas, Interaction of Chlamydiae with human macrophages, FEBS Journal, 283, 4, 2016. Crossref
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Rusconi Brigida, Greub Gilbert, Chlamydialesand the innate immune response: friend or foe?, FEMS Immunology & Medical Microbiology, 61, 3, 2011. Crossref
-
Fischer Annette, Rudel Thomas, Subversion of Cell-Autonomous Host Defense by Chlamydia Infection, in Biology of Chlamydia, 412, 2016. Crossref
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Gracey Eric, Lin Aifeng, Akram Ali, Chiu Basil, Inman Robert D., Coers Jörn, Intracellular Survival and Persistence of Chlamydia muridarum Is Determined by Macrophage Polarization, PLoS ONE, 8, 8, 2013. Crossref
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Asquith Kelly L., Horvat Jay C., Kaiko Gerard E., Carey Alison J., Beagley Kenneth W., Hansbro Philip M., Foster Paul S., Roy Craig R., Interleukin-13 Promotes Susceptibility to Chlamydial Infection of the Respiratory and Genital Tracts, PLoS Pathogens, 7, 5, 2011. Crossref
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JIANG PING, LI CHUNBO, XIANG ZHENGHUA, JIAO BINGHUA, Tanshinone IIA reduces the risk of Alzheimer’s disease by inhibiting iNOS, MMP-2 and NF-κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer’s disease, Molecular Medicine Reports, 10, 2, 2014. Crossref
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Mukura Lucy Rudo, Hickey Danica K., Rodriguez-Garcia Marta, Fahey John V., Wira Charles R., Chlamydia trachomatisregulates innate immune barrier integrity and mediates cytokine and antimicrobial responses in human uterine ECC-1 epithelial cells, American Journal of Reproductive Immunology, 78, 6, 2017. Crossref
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Hansbro Philip M., Kim Richard Y., Starkey Malcolm R., Donovan Chantal, Dua Kamal, Mayall Jemma R., Liu Gang, Hansbro Nicole G., Simpson Jodie L., Wood Lisa G., Hirota Jeremy A., Knight Darryl A., Foster Paul S., Horvat Jay C., Mechanisms and treatments for severe, steroid‐resistant allergic airway disease and asthma, Immunological Reviews, 278, 1, 2017. Crossref
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Beckett Emma L., Phipps Simon, Starkey Malcolm R., Horvat Jay C., Beagley Kenneth W., Foster Paul S., Hansbro Philip M., Metzger Dennis W., TLR2, but Not TLR4, Is Required for Effective Host Defence against Chlamydia Respiratory Tract Infection in Early Life, PLoS ONE, 7, 6, 2012. Crossref
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Lausen Mads, Christiansen Gunna, Bouet Guldbæk Poulsen Thomas, Birkelund Svend, Immunobiology of monocytes and macrophages during Chlamydia trachomatis infection, Microbes and Infection, 21, 2, 2019. Crossref
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Lausen Mads, Christiansen Gunna, Karred Nichlas, Winther Robert, Poulsen Thomas Bouet Guldbæk, Palarasah Yaseelan, Birkelund Svend, Complement C3 opsonization of Chlamydia trachomatis facilitates uptake in human monocytes, Microbes and Infection, 20, 6, 2018. Crossref
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Armitage Charles W., Carey Alison J., Hickey Danica K., Beagley Kenneth W., Chlamydia Trachomatis Urogenital Infections, in Diagnostics to Pathogenomics of Sexually Transmitted Infections, 2018. Crossref
-
Virok Dezső P., Raffai Tímea, Kókai Dávid, Paróczai Dóra, Bogdanov Anita, Veres Gábor, Vécsei László, Poliska Szilárd, Tiszlavicz László, Somogyvári Ferenc, Endrész Valéria, Burián Katalin, Indoleamine 2,3-Dioxygenase Activity in Chlamydia muridarum and Chlamydia pneumoniae Infected Mouse Lung Tissues, Frontiers in Cellular and Infection Microbiology, 9, 2019. Crossref
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Bryan Emily R, Kollipara Avinash, Trim Logan K, Armitage Charles W, Carey Alison J, Mihalas Bettina, Redgrove Kate A, McLaughlin Eileen A, Beagley Kenneth W, Hematogenous dissemination of Chlamydia muridarum from the urethra in macrophages causes testicular infection and sperm DNA damage†, Biology of Reproduction, 101, 4, 2019. Crossref
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Fiegl Dorothee, Kägebein Danny, Liebler-Tenorio Elisabeth M., Weisser Tanja, Sens Mareen, Gutjahr Melanie, Knittler Michael R., Amphisomal Route of MHC Class I Cross-Presentation in Bacteria-Infected Dendritic Cells, The Journal of Immunology, 190, 6, 2013. Crossref
-
Chen Hongliang, Wen Yating, Li Zhongyu, Clear Victory for Chlamydia: The Subversion of Host Innate Immunity, Frontiers in Microbiology, 10, 2019. Crossref
-
Woods Jason J., Skelding Kathryn A., Martin Kristy L., Aryal Ritambhara, Sontag Estelle, Johnstone Daniel M., Horvat Jay C., Hansbro Philip M., Milward Elizabeth A., Assessment of evidence for or against contributions of Chlamydia pneumoniae infections to Alzheimer’s disease etiology, Brain, Behavior, and Immunity, 83, 2020. Crossref
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Taavitsainen Eveliina, Kortesoja Maarit, Bruun Tanja, Johansson Niklas G., Hanski Leena, Assaying Chlamydia pneumoniae Persistence in Monocyte-Derived Macrophages Identifies Dibenzocyclooctadiene Lignans as Phenotypic Switchers, Molecules, 25, 2, 2020. Crossref
-
Kortesoja Maarit, Trofin Raluca Elena, Hanski Leena, A platform for studying the transfer of Chlamydia pneumoniae infection between respiratory epithelium and phagocytes, Journal of Microbiological Methods, 171, 2020. Crossref
-
Lee Jia Ming, Mayall Jemma R., Chevalier Anne, McCarthy Huw, Van Helden Dirk, Hansbro Philip M., Horvat Jay C., Jobling Phillip, Chlamydia muridarum infection differentially alters smooth muscle function in mouse uterine horn and cervix, American Journal of Physiology-Endocrinology and Metabolism, 318, 6, 2020. Crossref
-
Федорова В.А., Ляпина А.М., Хижнякова М.А., Зайцев С.С., Салтыков Ю.В., Субботина И.А., Филонова Н.Н., Колосова А.А., Ларионова О.С, Ульянова О.В., Грашкина И.Г., Ульянов С.С., Мотин В.Л., Хламидиозы животных и человека, 2019. Crossref
-
Galvão Izabela, Kim Richard Y., Shen Sijie, Budden Kurtis F., Vieira Angélica T., Hansbro Philip M., Emerging therapeutic targets and preclinical models for severe asthma, Expert Opinion on Therapeutic Targets, 24, 9, 2020. Crossref
-
Cochrane Melanie, Armitage Charles W, O’Meara Connor P, Beagley Kenneth W, Towards a Chlamydia trachomatis vaccine: how close are we?, Future Microbiology, 5, 12, 2010. Crossref
-
Sun Ping, Yin Jun-Bo, Liu Li-Hua, Guo Jian, Wang Sheng-Hai, Qu Chun-Hui, Wang Chun-Xia, Protective role of Dihydromyricetin in Alzheimer’s disease rat model associated with activating AMPK/SIRT1 signaling pathway, Bioscience Reports, 39, 1, 2019. Crossref
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Kortesoja Maarit, Taavitsainen Eveliina, Hanski Leena, The influence of dibenzocyclooctadiene lignans on macrophage glutathione and lipid metabolism associated with Chlamydia pneumoniae-induced foam cell formation, Advances in Redox Research, 1, 2021. Crossref
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Fung Ka Yee, Mangan Niamh E., Cumming Helen, Horvat Jay C., Mayall Jemma R., Stifter Sebastian A., De Weerd Nicole, Roisman Laila C., Rossjohn Jamie, Robertson Sarah A., Schjenken John E., Parker Belinda, Gargett Caroline E., Nguyen Hong P. T., Carr Daniel J., Hansbro Philip M., Hertzog Paul J., Interferon-ε Protects the Female Reproductive Tract from Viral and Bacterial Infection, Science, 339, 6123, 2013. Crossref
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Chacko Anu, Delbaz Ali, Walkden Heidi, Basu Souptik, Armitage Charles W., Eindorf Tanja, Trim Logan K., Miller Edith, West Nicholas P., St John James A., Beagley Kenneth W., Ekberg Jenny A. K., Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk, Scientific Reports, 12, 1, 2022. Crossref
-
Fields K. A., McCormack R., de Armas L. R., Podack E. R., Morrison R. P., Perforin-2 Restricts Growth of Chlamydia trachomatis in Macrophages, Infection and Immunity, 81, 8, 2013. Crossref
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Vasilevsky Sam, Greub Gilbert, Nardelli-Haefliger Denise, Baud David, Genital Chlamydia trachomatis: Understanding the Roles of Innate and Adaptive Immunity in Vaccine Research, Clinical Microbiology Reviews, 27, 2, 2014. Crossref
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Starkey Malcolm R., Nguyen Duc H., Brown Alexandra C., Essilfie Ama-Tawiah, Kim Richard Y., Yagita Hideo, Horvat Jay C., Hansbro Philip M., Programmed Death Ligand 1 Promotes Early-Life Chlamydia Respiratory Infection–Induced Severe Allergic Airway Disease, American Journal of Respiratory Cell and Molecular Biology, 54, 4, 2016. Crossref