Publication de 6 numéros par an
ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472
Indexed in
T Cell Proliferation and Homeostasis: An Emerging Role for the Cell Cycle Inhibitor Geminin
RÉSUMÉ
Thymic T cell differentiation to peripheral T cells aims to assist the generation of effector cells mediating adaptive immune responses. During this process, which takes place during embryogenesis and in adulthood, proliferation is coupled with changes in chromatin organization and transcription. Moreover, B and T lymphocytes start to proliferate and rapidly expand their numbers when activated following an encounter with an antigen. This expansion phase is accompanied by differentiation of naпve T cells and is followed by a period of population contraction, resulting in only a small fraction of the expanded population surviving and entering the memory cell pool. The kinetics of the expansion and contraction affect the speed of antigen clearance and the clinical course of disease. Molecules that are involved in the coordination of proliferation, chromatin reorganization, and transcriptional regulation are likely to play an important role in T cell generation, homeostasis, and disease. Here we review how cell cycle regulators affect lymphoid system development and homeostasis and discuss recent evidence implicating the cell cycle inhibitor Geminin in this process. Geminin has been shown to coordinate proliferation and differentiation by regulating cell cycle progression, chromatin organization, and transcription in the nervous system. In the immune system, progenitor T cell commitment and differentiation progresses normally in the absence of Geminin. However, Geminin is required for TCR response in vitro and T cell proliferation upon lymphopenia-induced proliferation, suggesting that Geminin might be an essential factor for T cell expansion during the immune response.
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Stathopoulou Athanasia, Natarajan Dipa, Nikolopoulou Pinelopi, Patmanidi Alexandra L., Lygerou Zoi, Pachnis Vassilis, Taraviras Stavros, Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis, Developmental Biology, 409, 2, 2016. Crossref
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Kushwaha Prem Prakash, Rapalli Krishna Chaitanya, Kumar Shashank, Geminin a multi task protein involved in cancer pathophysiology and developmental process: A review, Biochimie, 131, 2016. Crossref
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Rashid Muhammad, Liu Junlong, Guan Guiquan, Wang Jinming, Li Zhi, Hassan Muhammad Adeel, Rashid Muhammad Imran, Mukhtar Muhammad Uzair, Luo Jianxun, Yin Hong, In vitroinfluence ofTheileria annulataon the functions of bovine dendritic cells for stimulation of T lymphocyte proliferation, Parasitology, 147, 1, 2020. Crossref
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Karamitros Dimitris, Patmanidi Alexandra L., Kotantaki Panoraia, Potocnik Alexandre J., Bähr-Ivacevic Tomi, Benes Vladimir, Lygerou Zoi, Kioussis Dimitris, Taraviras Stavros, Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors, Development, 142, 1, 2015. Crossref
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Thakur Pratima, Dadsetan Sepehr, Fomina Alla F., Bidirectional Coupling between Ryanodine Receptors and Ca2+ Release-activated Ca2+ (CRAC) Channel Machinery Sustains Store-operated Ca2+ Entry in Human T Lymphocytes, Journal of Biological Chemistry, 287, 44, 2012. Crossref
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Patmanidi Alexandra L., Champeris Tsaniras Spyridon, Karamitros Dimitris, Kyrousi Christina, Lygerou Zoi, Taraviras Stavros, Concise Review: Geminin—A Tale of Two Tails: DNA Replication and Transcriptional/Epigenetic Regulation in Stem Cells, Stem Cells, 35, 2, 2017. Crossref