Publication de 6 numéros par an
ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472
Indexed in
Role of CD8 T-Cell-Mediated Autoimmune Diseases of the Central Nervous System
RÉSUMÉ
In T-cell-mediated autoimmune diseases of the central nervous system (CNS), CD4 T cells have long been regarded as the only pathogenetically relevant T-cell population. However, growing clinical and experimental evidence suggests that CD8 T cells also contribute significantly to autoimmune responses in the CNS. We discuss the potential induction of autoimmune CD8 T cells by infections, the impact of the microenvironment of the CNS on CD8 T-cell responses, and the potential interaction of CD8 T cells with autoantigen-expressing resident brain-cell populationsneurons in particularin light of clinical and experimental findings.
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Trépanier Patrick, Chabot Dominique, Bazin Renée, Intravenous immunoglobulin modulates the expansion and cytotoxicity of CD8+T cells, Immunology, 141, 2, 2014. Crossref
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Biscetti Leonardo, De Vanna Gioacchino, Cresta Elena, Corbelli Ilenia, Gaetani Lorenzo, Cupini Letizia, Calabresi Paolo, Sarchielli Paola, Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms, Journal of Neuroinflammation, 18, 1, 2021. Crossref
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Biscetti Leonardo, De Vanna Gioacchino, Cresta Elena, Bellotti Alessia, Corbelli Ilenia, Letizia Cupini Maria, Calabresi Paolo, Sarchielli Paola, Immunological findings in patients with migraine and other primary headaches: a narrative review, Clinical and Experimental Immunology, 207, 1, 2022. Crossref