Publication de 6 numéros par an
ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472
Indexed in
T- and B-Cell Abnormalities in Systemic Lupus Erythematosus
RÉSUMÉ
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the production of antinuclear autoantibodies and clinical involvement in multiple organ systems. T cells from patients with SLE have been shown to be activated in vivo and provide help to autoreactive B cells. Abnormal expression of key signaling molecules, defective signal transduction pathways, and permanent mitochondrial dysfunctionassociated with a significantly increased mitochondrial massappear to be the axis of T-lymphocyte dysfunction. Lupus T cells exhibit persistent mitochondrial hyperpolarization (MHP), cytoplasmic alkalinization, increased ROI production, and ATP depletion that mediate enhanced spontaneous and diminished activation-induced apoptosis and sensitize lupus T cells to necrosis. Necrotic, but not apoptotic, cell lysates activate dendritic cells and may account for increased interferon-α production, inflammation, and antinuclear antibody production. Recent data indicate that B cells are not merely the passive producers of autoantibodies, but also play a central role in autoimmunity via nonconventional mechanisms, including autoantigen presentation and modulation of other immune cells. This article reviews recent advancements in the understanding of the molecular mechanisms involved in the pathogenesis of lupus autoimmunity and highlights the development of novel therapies in SLE.
-
Monrad Seetha, Kaplan Mariana J., Dendritic cells and the immunopathogenesis of systemic lupus erythematosus, Immunologic Research, 37, 2, 2007. Crossref
-
Perl Andras, Fernandez David R, Telarico Tiffany, Doherty Edward, Francis Lisa, Phillips Paul E, T-cell and B-cell signaling biomarkers and treatment targets in lupus, Current Opinion in Rheumatology, 21, 5, 2009. Crossref
-
Fernandez David, Bonilla Eduardo, Mirza Naureen, Niland Brian, Perl Andras, Rapamycin reduces disease activity and normalizes T cell activation–induced calcium fluxing in patients with systemic lupus erythematosus, Arthritis & Rheumatism, 54, 9, 2006. Crossref
-
Jury Elizabeth C., Flores-Borja Fabian, Kalsi Hardeep S., Lazarus Mark, Isenberg David A., Mauri Claudia, Ehrenstein Michael R., Abnormal CTLA-4 function in T cells from patients with systemic lupus erythematosus, European Journal of Immunology, 40, 2, 2010. Crossref
-
Wang Huiming, Yang Zhao, Li Fan, He Yani, Wang Shuguang, Yang Di, Wu Yuzhang, Insertion of a Targeting Peptide on Capsid Surface Loops of Human Papillomavirus Type-16 Virus-like Particles Mediate Elimination of Anti-dsDNA Abs-producing B Cells With High Efficiency, Journal of Immunotherapy, 32, 1, 2009. Crossref
-
Michalek Ryan D., Rathmell Jeffrey C., The metabolic life and times of a T-cell, Immunological Reviews, 236, 1, 2010. Crossref
-
Ben-David Hava, Sharabi Amir, Parameswaran Reshmi, Zinger Heidy, Mozes Edna, A tolerogenic peptide down-regulates mature B cells in bone marrow of lupus-afflicted mice by inhibition of interleukin-7, leading to apoptosis, Immunology, 128, 2, 2009. Crossref
-
Deak Eszter, Jayakumar Asha, Cho Ka Wing, Goldsmith‐Pestana Karen, Dondji Blaise, Lambris John D., McMahon‐Pratt Diane, Murine visceral leishmaniasis: IgM and polyclonal B‐cell activation lead to disease exacerbation, European Journal of Immunology, 40, 5, 2010. Crossref
-
Froy Oren, Sthoeger Zev M., Defensins in Systemic Lupus Erythematosus, Annals of the New York Academy of Sciences, 1173, 1, 2009. Crossref
-
Sarra Massimiliano, Monteleone Giovanni, Interleukin-21: A New Mediator of Inflammation in Systemic Lupus Erythematosus, Journal of Biomedicine and Biotechnology, 2010, 2010. Crossref
-
Catapano F., Chaudhry A. N., Jones R. B., Smith K. G. C., Jayne D. W., Long-term efficacy and safety of rituximab in refractory and relapsing systemic lupus erythematosus, Nephrology Dialysis Transplantation, 25, 11, 2010. Crossref
-
Sharabi Amir, Dayan Molly, Zinger Heidy, Mozes Edna, A New Model of Induced Experimental Systemic Lupus Erythematosus (SLE) in Pigs and Its Amelioration by Treatment with a Tolerogenic Peptide, Journal of Clinical Immunology, 30, 1, 2010. Crossref
-
Okazaki Shihoko, Ogawa Fumihide, Iwata Yohei, Hara Toshihide, Muroi Eiji, Komura Kazuhiro, Takenaka Motoi, Shimizu Kazuhiro, Hasegawa Minoru, Fujimoto Manabu, Sato Shinichi, Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis, Rheumatology International, 30, 7, 2010. Crossref
-
Ka S.-M., Kuo Y.-C., Ho P.-J., Tsai P.-Y., Hsu Y.-J., Tsai W.-J., Lin Y.-L., Shen C.-C., Chen A., (S)-armepavine from Chinese medicine improves experimental autoimmune crescentic glomerulonephritis, Rheumatology, 49, 10, 2010. Crossref
-
Gáti Tamás, Pajor Attila, Géher Pál, Nagy György, Systemic lupus erythematosus and pregnancy, Orvosi Hetilap, 149, 16, 2008. Crossref
-
Monrad Seetha U, Desch Karl C, Kaplan Mariana J, Role of dendritic cells in the pathogenesis of systemic lupus erythematosus, Future Rheumatology, 3, 3, 2008. Crossref
-
Parameswaran Reshmi, David Hava Ben, Sharabi Amir, Zinger Heidy, Mozes Edna, B-cell activating factor (BAFF) plays a role in the mechanism of action of a tolerogenic peptide that ameliorates lupus, Clinical Immunology, 131, 2, 2009. Crossref
-
Azab N.A., Bassyouni I.H., Emad Y., Abd El-Wahab G.A., Hamdy G., Mashahit M.A., CD4+CD25+ regulatory T cells (TREG) in Systemic Lupus Erythematosus (SLE) patients: The possible influence of treatment with corticosteroids, Clinical Immunology, 127, 2, 2008. Crossref
-
Sthoeger Zev M., Sharabi Amir, Dayan Molly, Zinger Heidy, Asher Ilan, Sela Uri, Mozes Edna, The tolerogenic peptide hCDR1 downregulates pathogenic cytokines and apoptosis and upregulates immunosuppressive molecules and regulatory T cells in peripheral blood mononuclear cells of lupus patients, Human Immunology, 70, 3, 2009. Crossref
-
Reynolds John A, Bruce Ian N, Vitamin D in systemic lupus erythematosus: potential beyond bone health, International Journal of Clinical Rheumatology, 4, 3, 2009. Crossref
-
Sarra Massimiliano, Franzè Eleonora, Pallone Francesco, Monteleone Giovanni, Targeting interleukin-21 in inflammatory diseases, Expert Opinion on Therapeutic Targets, 15, 6, 2011. Crossref
-
Krishnan Sandeep, Chowdhury Bhabadeb, Tsokos George C., Autoimmunity in systemic lupus erythematosus: Integrating genes and biology, Seminars in Immunology, 18, 4, 2006. Crossref
-
Hsu Tsai-Ching, Huang Chih-Yang, Chiang Szu-Yi, Lai Wen-Xian, Tsai Chang-Hai, Tzang Bor-Show, Transglutaminase inhibitor cystamine alleviates the abnormality in liver from NZB/W F1 mice, European Journal of Pharmacology, 579, 1-3, 2008. Crossref
-
Perl Andras, Overview of signal processing by the immune system in systemic lupus erythematosus, Autoimmunity Reviews, 8, 3, 2009. Crossref
-
Peng Stanford L., Altered T and B lymphocyte signaling pathways in lupus, Autoimmunity Reviews, 8, 3, 2009. Crossref
-
Li Di, Song Lijun, Fan Yuchen, Li Xia, Li Yingjie, Chen Jie, Zhu Faliang, Guo Chun, Shi Yongyu, Zhang Lining, Down-regulation of TIPE2 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus, Clinical Immunology, 133, 3, 2009. Crossref
-
Liu Kui, Mohan Chandra, Altered B-cell signaling in lupus, Autoimmunity Reviews, 8, 3, 2009. Crossref
-
Ankeny Daniel P., Popovich Phillip G., B cells and autoantibodies: complex roles in CNS injury, Trends in Immunology, 31, 9, 2010. Crossref
-
Novick Daniela, Elbirt Daniel, Miller Galit, Dinarello Charles A., Rubinstein Menachem, Sthoeger Zev M., High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein, Journal of Autoimmunity, 34, 2, 2010. Crossref
-
Sthoeger Zev M., Sharabi Amir, Molad Yair, Asher Ilan, Zinger Heidy, Dayan Molly, Mozes Edna, Treatment of lupus patients with a tolerogenic peptide, hCDR1 (Edratide): Immunomodulation of gene expression, Journal of Autoimmunity, 33, 1, 2009. Crossref
-
Sheng Y.-J., Gao J.-P., Li J., Han J.-W., Xu Q., Hu W.-L., Pan T.-M., Cheng Y.-L., Yu Z.-Y., Ni C., Yao S., He C.-F., Liu Y.-S., Li Y., Ge H.-M., Xiao F.-L., Sun L.-D., Yang S., Zhang X.-J., Follow-up study identifies two novel susceptibility loci PRKCB and 8p11.21 for systemic lupus erythematosus, Rheumatology, 50, 4, 2011. Crossref
-
Xue Chen, Lan-lan Wang, Bei Cai, Jie Chen, Wei-hua Feng, Abnormal Fas/FasL and caspase-3-mediated apoptotic signaling pathways of T lymphocyte subset in patients with systemic lupus erythematosus, Cellular Immunology, 239, 2, 2006. Crossref
-
Foster Mary H., T Cells and B Cells in Lupus Nephritis, Seminars in Nephrology, 27, 1, 2007. Crossref
-
Deshmukh Umesh S., Sim Davis L., Dai Chao, Kannapell Carol J., Gaskin Felicia, Rajagopalan Govindarajan, David Chella S., Fu Shu Man, HLA-DR3 restricted T cell epitope mimicry in induction of autoimmune response to lupus-associated antigen SmD, Journal of Autoimmunity, 37, 3, 2011. Crossref
-
Sthoeger Zev M., Bezalel Shira, Chapnik Nava, Asher Ilan, Froy Oren, High α-defensin levels in patients with systemic lupus erythematosus, Immunology, 127, 1, 2009. Crossref
-
Telerman Alona, Lapter Smadar, Sharabi Amir, Zinger Heidy, Mozes Edna, Induction of hippocampal neurogenesis by a tolerogenic peptide that ameliorates lupus manifestations, Journal of Neuroimmunology, 232, 1-2, 2011. Crossref
-
Nagy Gyorgy, Perl Andras, The role of nitric oxide in abnormal T cell signal transduction in systemic lupus erythematosus, Clinical Immunology, 118, 2-3, 2006. Crossref
-
Abud-Mendoza Carlos, Moreno-Valdés Ricardo, Cuevas-Orta Enrique, Borjas Antonio, Aranda Francisco, Irazoque Fedra, Andrade Lilia, Vigna-Pérez M., González-Amaro R., Treating severe systemic lupus erythematosus with rituximab. An open study, Reumatología Clínica (English Edition), 5, 4, 2009. Crossref
-
He Chunyan, Lu Xuehong, Yan Zhaowei, Wu Man, Liu Shujun, Yu Yongli, Luo Ping, Therapeutic effect of leflunomide on the development of experimental lupus nephritis in mice, Rheumatology International, 32, 3, 2012. Crossref
-
Abud-Mendoza Carlos, Moreno-Valdés Ricardo, Cuevas-Orta Enrique, Borjas Antonio, Aranda Francisco, Irazoque Fedra, Andrade Lilia, Vigna-Pérez M., González-Amaro R., Treating severe systemic lupus erythematosus with rituximab. An open study, Reumatología Clínica, 5, 4, 2009. Crossref
-
Jeon Young Ho, Lee Jin Young, Kim Sunghoon, Chemical modulators working at pharmacological interface of target proteins, Bioorganic & Medicinal Chemistry, 20, 6, 2012. Crossref
-
Gorelik Gabriela J., Yarlagadda Sushma, Richardson Bruce C., Protein kinase Cδ oxidation contributes to ERK inactivation in lupus T cells, Arthritis & Rheumatism, 64, 9, 2012. Crossref
-
Ortona Elena, Maselli Angela, Delunardo Federica, Colasanti Tania, Giovannetti Antonello, Pierdominici Marina, Relationship Between Redox Status and Cell Fate in Immunity and Autoimmunity, Antioxidants & Redox Signaling, 21, 1, 2014. Crossref
-
Oaks Zachary, Perl Andras, Metabolic control of the epigenome in systemic Lupus erythematosus, Autoimmunity, 47, 4, 2014. Crossref
-
Merrill Joan T., Co-stimulatory molecules as targets for treatment of lupus, Clinical Immunology, 148, 3, 2013. Crossref
-
Koga Hiroshi, Tsuruta Daisuke, Ohyama Bungo, Ishii Norito, Hamada Takahiro, Ohata Chika, Furumura Minao, Hashimoto Takashi, Desmoglein 3, its pathogenecity and a possibility for therapeutic target in pemphigus vulgaris, Expert Opinion on Therapeutic Targets, 17, 3, 2013. Crossref
-
Liao Jieyue, Chang Christopher, Wu Haijing, Lu Qianjin, Cell-based therapies for systemic lupus erythematosus, Autoimmunity Reviews, 14, 1, 2015. Crossref
-
Caza Tiffany, Oaks Zachary, Perl Andras, Interplay of Infections, Autoimmunity, and Immunosuppression in Systemic Lupus Erythematosus, International Reviews of Immunology, 33, 4, 2014. Crossref
-
Mackay Fabienne, Gommerman Jennifer L., The Role of the BAFF and Lymphotoxin Pathways in B Cell Biology, in Molecular Biology of B Cells, 2015. Crossref
-
Colasanti T, Vomero M, Alessandri C, Barbati C, Maselli A, Camperio C, Conti F, Tinari A, Carlo-Stella C, Tuosto L, Benincasa D, Valesini G, Malorni W, Pierdominici M, Ortona E, Role of alpha-synuclein in autophagy modulation of primary human T lymphocytes, Cell Death & Disease, 5, 5, 2014. Crossref
-
Pan Qingjun, Gao Caina, Chen Yanwen, Feng Yongmin, Liu Wei Jing, Liu Hua-feng, Update on the role of autophagy in systemic lupus erythematosus: A novel therapeutic target, Biomedicine & Pharmacotherapy, 71, 2015. Crossref
-
Barbati Cristiana, Alessandri Cristiano, Vomero Marta, Vona Rosa, Colasanti Tania, Vacirca Davide, Camerini Serena, Crescenzi Marco, Pendolino Monica, Truglia Simona, Conti Fabrizio, Garofalo Tina, Sorice Maurizio, Pierdominici Marina, Valesini Guido, Malorni Walter, Ortona Elena, Autoantibodies specific to D4GDI modulate Rho GTPase mediated cytoskeleton remodeling and induce autophagy in T lymphocytes, Journal of Autoimmunity, 58, 2015. Crossref
-
Reina Silvia, Pisoni Cecilia, Eimon Alicia, Carrizo Carolina, Arana Roberto, Borda Enri, Anti-M<sub>3</sub> Muscarinic Acetylcholine Receptor Antibodies in Systemic Lupus Erythematosus, Pharmacology & Pharmacy, 06, 01, 2015. Crossref
-
De Riccardis Lidia, Ferramosca Alessandra, Danieli Antonio, Trianni Giorgio, Zara Vincenzo, De Robertis Francesca, Maffia Michele, Metabolic response to glatiramer acetate therapy in multiple sclerosis patients, BBA Clinical, 6, 2016. Crossref
-
Urowitz Murray B, Isenberg David A, Wallace Daniel J, Safety and efficacy of hCDR1 (Edratide) in patients with active systemic lupus erythematosus: results of phase II study, Lupus Science & Medicine, 2, 1, 2015. Crossref
-
Kyttaris Vasileios C., Krishnan Sandeep, Tsokos George C., Systems biology in systemic lupus erythematosus: Integrating genes, biology and immune function, Autoimmunity, 39, 8, 2006. Crossref
-
Rojas-Villarraga Adriana, Torres-Gonzalez July-Vianneth, Ruiz-Sternberg Ángela-María, Sawalha Amr H., Safety of Hormonal Replacement Therapy and Oral Contraceptives in Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis, PLoS ONE, 9, 8, 2014. Crossref
-
Montiel JL, Monsiváis-Urenda A, Figueroa-Vega N, Moctezuma JF, Burgos-Vargas R, González-Amaro R, Rosenstein Y, Anti-CD43 and anti-galectin-1 autoantibodies in patients with systemic lupus erythematosus, Scandinavian Journal of Rheumatology, 39, 1, 2010. Crossref
-
Guo Lele, Liu Wen, Lu Tingting, Guo Wenjie, Gao Jian, Luo Qiong, Wu Xuefeng, Sun Yang, Wu Xudong, Shen Yan, Xu Qiang, van der Vlag Johan, Decrease of Functional Activated T and B Cells and Treatment of Glomerulonephitis in Lupus-Prone Mice Using a Natural Flavonoid Astilbin, PLOS ONE, 10, 4, 2015. Crossref
-
Glesse N, Vianna P, Paim L M G, Matte M C C, Aguiar A K K, Palhano P L, Monticielo O A, Brenol C V, Xavier R M, Chies J A B, Evaluation of polymorphic variants in apoptotic genes and their role in susceptibility and clinical progression to systemic lupus erythematosus, Lupus, 26, 7, 2017. Crossref
-
Mathis Keisa W., An impaired neuroimmune pathway promotes the development of hypertension in systemic lupus erythematosus, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 309, 9, 2015. Crossref
-
Umare Vinod, Pradhan Vandana, Rajadhyaksha Anjali, Ghosh Kanjaksha, Nadkarni Anita, Predisposition of IL-1β (-511 C/T) polymorphism to renal and hematologic disorders in Indian SLE patients, Gene, 641, 2018. Crossref
-
Scherl M, Posch U, Obermoser G, Ammann C, Sepp N, Ulmer H, Dierich M P, Stoiber H, Falkensammer B, Targeting human immunodeficiency virus type 1 with antibodies derived from patients with connective tissue disease, Lupus, 15, 12, 2006. Crossref
-
Bragazzi Nicola Luigi, Watad Abdulla, Sharif Kassem, Adawi Mohammad, Aljadeff Gali, Amital Howard, Shoenfeld Yehuda, Advances in our understanding of immunization and vaccines for patients with systemic lupus erythematosus, Expert Review of Clinical Immunology, 13, 10, 2017. Crossref
-
Ye Xin, Zhou Xu-Jie, Zhang Hong, Exploring the Role of Autophagy-Related Gene 5 (ATG5) Yields Important Insights Into Autophagy in Autoimmune/Autoinflammatory Diseases, Frontiers in Immunology, 9, 2018. Crossref
-
Shin Woori, Lee Hyun Tae, Lim Heejin, Lee Sang Hyung, Son Ji Young, Lee Jee Un, Yoo Ki-Young, Ryu Seong Eon, Rhie Jaejun, Lee Ju Yeon, Heo Yong-Seok, BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus, Nature Communications, 9, 1, 2018. Crossref
-
Pierdominici Marina, Vomero Marta, Barbati Cristiana, Colasanti Tania, Maselli Angela, Vacirca Davide, Giovannetti Antonello, Malorni Walter, Ortona Elena, Role of autophagy in immunity and autoimmunity, with a special focus on systemic lupus erythematosus, The FASEB Journal, 26, 4, 2012. Crossref
-
Weder Bruce, Mamie Céline, Rogler Gerhard, Clarke Stephen, McRae Bradford, Ruiz Pedro A, Hausmann Martin, BCL2 Regulates Differentiation of Intestinal Fibroblasts, Inflammatory Bowel Diseases, 24, 9, 2018. Crossref
-
Sharabi Amir, Luger Dror, Ben-David Hava, Dayan Molly, Zinger Heidey, Mozes Edna, The Role of Apoptosis in the Ameliorating Effects of a CDR1-Based Peptide on Lupus Manifestations in a Mouse Model, The Journal of Immunology, 179, 8, 2007. Crossref
-
Fernandez David R., Telarico Tiffany, Bonilla Eduardo, Li Qing, Banerjee Sanjay, Middleton Frank A., Phillips Paul E., Crow Mary K., Oess Stefanie, Muller-Esterl Werner, Perl Andras, Activation of Mammalian Target of Rapamycin Controls the Loss of TCRζ in Lupus T Cells through HRES-1/Rab4-Regulated Lysosomal Degradation, The Journal of Immunology, 182, 4, 2009. Crossref
-
Ka Shuk-Man, Sytwu Huey-Kang, Chang Deh-Ming, Hsieh Shie-Liang, Tsai Pei-Yi, Chen Ann, Decoy Receptor 3 Ameliorates an Autoimmune Crescentic Glomerulonephritis Model in Mice, Journal of the American Society of Nephrology, 18, 9, 2007. Crossref
-
Bardwell Philip D., Gu Jijie, McCarthy Donna, Wallace Craig, Bryant Shaughn, Goess Christian, Mathieu Suzanne, Grinnell Chris, Erickson Jamie, Rosenberg Saul H., Schwartz Annette J., Hugunin Margaret, Tarcsa Edit, Elmore Steven W., McRae Bradford, Murtaza Anwar, Wang Li Chun, Ghayur Tariq, The Bcl-2 Family Antagonist ABT-737 Significantly Inhibits Multiple Animal Models of Autoimmunity, The Journal of Immunology, 182, 12, 2009. Crossref
-
Érsek Barbara, Molnár Viktor, Balogh Andrea, Matkó János, Cope Andrew P., Buzás Edit I., Falus András, Nagy György, CD3ζ-Chain Expression of Human T Lymphocytes Is Regulated by TNF via Src-like Adaptor Protein-Dependent Proteasomal Degradation, The Journal of Immunology, 189, 4, 2012. Crossref
-
Cuda Carla M., Li Shiwu, Liang Shujuan, Yin Yiming, Potula Hari Hara S. K., Xu Zhiwei, Sengupta Mayami, Chen Yifang, Butfiloski Edward, Baker Henry, Chang Lung-Ji, Dozmorov Igor, Sobel Eric S., Morel Laurence, Pre-B Cell Leukemia Homeobox 1 Is Associated with Lupus Susceptibility in Mice and Humans, The Journal of Immunology, 188, 2, 2012. Crossref
-
Bright John J., CURCUMIN AND AUTOIMMUNE DISEASE, in The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, 595, 2007. Crossref
-
Zhu Qingqing, Li Yun, Zhang Lili, Wang Min, Chen Zhongxin, Shi Junxiang, Li Ji, Li Baiqing, Li Zhijun, Wang Yuanyuan, Xie Changhao, Patients with systemic lupus erythematosus show increased proportions of CD19+CD20− B cells and secretion of related autoantibodies, Clinical Rheumatology, 40, 1, 2021. Crossref
-
Yang Shi-Kun, Zhang Hao-Ran, Shi Shu-Peng, Zhu Ying-Qiu, Song Na, Dai Qing, Zhang Wei, Gui Ming, Zhang Hao, The Role of Mitochondria in Systemic Lupus Erythematosus: A Glimpse of Various Pathogenetic Mechanisms, Current Medicinal Chemistry, 27, 20, 2020. Crossref
-
Lutz C, Mozaffari M, Tosevski V, Caj M, Cippà P, McRae B L, Graff C L, Rogler G, Fried M, Hausmann M, Increased lymphocyte apoptosis in mouse models of colitis upon ABT-737 treatment is dependent upon BIM expression, Clinical and Experimental Immunology, 181, 2, 2015. Crossref
-
Weder B, Mozaffari M, Biedermann L, Mamie C, Moncsek A, Wang L, Clarke S H, Rogler G, McRae B L, Graff C L, Ruiz P A, Hausmann M, BCL-2 levels do not predict azathioprine treatment response in inflammatory bowel disease, but inhibition induces lymphocyte apoptosis and ameliorates colitis in mice, Clinical and Experimental Immunology, 193, 3, 2018. Crossref
-
Halvorsen Bente, Wæhre Torgun, Scholz Hanne, Damås Jan K, Yndestad Arne, Aukrust Pål, Role of interleukin-10 in atherogenesis and plaque stabilization, Future Cardiology, 2, 1, 2006. Crossref
-
Piantoni Silvia, Regola Francesca, Masneri Stefania, Merletti Michele, Lowin Torsten, Airò Paolo, Tincani Angela, Franceschini Franco, Andreoli Laura, Pongratz Georg, Characterization of B- and T-Cell Compartment and B-Cell Related Factors Belonging to the TNF/TNFR Superfamily in Patients With Clinically Active Systemic Lupus Erythematosus: Baseline BAFF Serum Levels Are the Strongest Predictor of Response to Belimumab after Twelve Months of Therapy, Frontiers in Pharmacology, 12, 2021. Crossref
-
Song Li-jun, Wang Xiao, Wang Xu-ping, Li Dong, Ding Feng, Liu Hua-xiang, Yu Xiao, Li Xing-fu, Shu Qiang, Increased Tim-3 expression on peripheral T lymphocyte subsets and association with higher disease activity in systemic lupus erythematosus, Diagnostic Pathology, 10, 1, 2015. Crossref
-
MacIver Nancie J., Michalek Ryan D., Rathmell Jeffrey C., Metabolic Regulation of T Lymphocytes, Annual Review of Immunology, 31, 1, 2013. Crossref
-
Martin‐Gutierrez Lucia, Peng Junjie, Thompson Nicolyn L., Robinson George A., Naja Meena, Peckham Hannah, Wu WingHan, J’bari Hajar, Ahwireng Nyarko, Waddington Kirsty E., Bradford Claire M., Varnier Giulia, Gandhi Akash, Radmore Rebecca, Gupta Vivek, Isenberg David A., Jury Elizabeth C., Ciurtin Coziana, Stratification of Patients With Sjögren’s Syndrome and Patients With Systemic Lupus Erythematosus According to Two Shared Immune Cell Signatures, With Potential Therapeutic Implications, Arthritis & Rheumatology, 73, 9, 2021. Crossref
-
Ma Terry King-Wing, McAdoo Stephen P., Tam Frederick Wai-Keung, Spleen Tyrosine Kinase: A Crucial Player and Potential Therapeutic Target in Renal Disease, Nephron, 133, 4, 2016. Crossref
-
Mantha Katarzyna, Laufer Benjamin I., Singh Shiva M., Molecular Changes during Neurodevelopment following Second-Trimester Binge Ethanol Exposure in a Mouse Model of Fetal Alcohol Spectrum Disorder: From Immediate Effects to Long-Term Adaptation, Developmental Neuroscience, 36, 1, 2014. Crossref
-
Zhang Mingchao, Johnson-Stephenson Takerra K., Wang Weiran, Wang Yang, Li Jing, Li Limin, Zen Ke, Chen Xi, Zhu Dihan, Mesenchymal stem cell-derived exosome-educated macrophages alleviate systemic lupus erythematosus by promoting efferocytosis and recruitment of IL-17+ regulatory T cell, Stem Cell Research & Therapy, 13, 1, 2022. Crossref
-
Rasking Leen, Roelens Céline, Sprangers Ben, Thienpont Bernard, Nawrot Tim S., De Vusser Katrien, Lupus, DNA Methylation, and Air Pollution: A Malicious Triad, International Journal of Environmental Research and Public Health, 19, 22, 2022. Crossref