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Critical Reviews™ in Immunology

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ISSN Imprimer: 1040-8401

ISSN En ligne: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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The Critical Role of the Antimicrobial Peptide LL-37/ CRAMP in Protection of Colon Microbiota Balance, Mucosal Homeostasis, Anti-Inflammatory Responses, and Resistance to Carcinogenesis

Volume 39, Numéro 2, 2019, pp. 83-92
DOI: 10.1615/CritRevImmunol.2019030225
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RÉSUMÉ

Mouse cathelin-related antimicrobial peptide (CRAMP) and its homologue human cathelicidin (LL-37) play active roles in innate immune responses, angiogenesis, and wound healing. In addition, LL-37/CRAMP fends off microbes and protects against infections in the colon, where the epithelium is exposed to myriad of enteric pathogens. It is increasingly recognized that LL-37/CRAMP maintains colon mucosal barrier integrity, shapes the composition of microbiota, and protects the host from tumorigenesis. In this review, we discuss the importance of LL-37/CRAMP in the homeostasis of the host, with novel findings derived from mice deficient in CRAMP that support the proposition for this natural antimicrobial peptide and an immune modulator as a drug lead for therapeutic development.

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CITÉ PAR
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  2. Konstantinidis Theocharis, Tsigalou Christina, Karvelas Alexandros, Stavropoulou Elisavet, Voidarou Chrissoula, Bezirtzoglou Eugenia, Effects of Antibiotics upon the Gut Microbiome: A Review of the Literature, Biomedicines, 8, 11, 2020. Crossref

  3. Chen Keqiang, Yoshimura Teizo, Yao Xiaohong, Gong Wanghua, Huang Jiaqiang, Dzutsev Amiran K, McCulloch John, O'hUigin Colm, Bian Xiu‐wu, Trinchieri Giorgio, Wang Ji Ming, Distinct contributions of cathelin‐related antimicrobial peptide ( CRAMP ) derived from epithelial cells and macrophages to colon mucosal homeostasis , The Journal of Pathology, 253, 3, 2021. Crossref

  4. Chen Keqiang, Yoshimura Teizo, Gong Wanghua, Tian Cuimeng, Huang Jiaqiang, Trinchieri Giorgio, Wang Ji Ming, Requirement of CRAMP for mouse macrophages to eliminate phagocytosed E. coli through an autophagy pathway, Journal of Cell Science, 134, 5, 2021. Crossref

  5. Porter Ross J, Murray Graeme I, Alnabulsi Abdo, Humphries Matthew P, James Jacqueline A, Salto‐Tellez Manuel, Craig Stephanie G, Wang Ji M, Yoshimura Teizo, McLean Mairi H, Colonic epithelial cathelicidin ( LL ‐37) expression intensity is associated with progression of colorectal cancer and presence of CD8 + T cell infiltrate , The Journal of Pathology: Clinical Research, 7, 5, 2021. Crossref

  6. Zhang Qi-Yu, Yan Zhi-Bin, Meng Yue-Ming, Hong Xiang-Yu, Shao Gang, Ma Jun-Jie, Cheng Xu-Rui, Liu Jun, Kang Jian, Fu Cai-Yun, Antimicrobial peptides: mechanism of action, activity and clinical potential, Military Medical Research, 8, 1, 2021. Crossref

  7. Zsila Ferenc, Ricci Maria, Szigyártó Imola Csilla, Singh Priyanka, Beke-Somfai Tamás, Quorum Sensing Pseudomonas Quinolone Signal Forms Chiral Supramolecular Assemblies With the Host Defense Peptide LL-37, Frontiers in Molecular Biosciences, 8, 2021. Crossref

  8. Sobiepanek Anna, Kuryk Łukasz, Garofalo Mariangela, Kumar Sandeep, Baran Joanna, Musolf Paulina, Siebenhaar Frank, Fluhr Joachim Wilhelm, Kobiela Tomasz, Plasenzotti Roberto, Kuchler Karl, Staniszewska Monika, The Multifaceted Roles of Mast Cells in Immune Homeostasis, Infections and Cancers, International Journal of Molecular Sciences, 23, 4, 2022. Crossref

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  10. McDonough Liam D., Mishra Animesh A., Tosini Nicholas, Kakade Pallavi, Penumutchu Swathi, Liang Shen-Huan, Maufrais Corrine, Zhai Bing, Taur Ying, Belenky Peter, Bennett Richard J., Hohl Tobias M., Koh Andrew Y., Ene Iuliana V., Berman Judith, Candida albicans Isolates 529L and CHN1 Exhibit Stable Colonization of the Murine Gastrointestinal Tract, mBio, 12, 6, 2021. Crossref

  11. Di Virgilio Francesco, Vultaggio-Poma Valentina, Sarti Alba Clara, P2X receptors in cancer growth and progression, Biochemical Pharmacology, 187, 2021. Crossref

  12. Moeinabadi-Bidgoli Kasra, Rezaee Malihe, Rismanchi Hamidreza, Mohammadi Mohaddese Malek, Babajani Amirhesam, Mesenchymal Stem Cell-Derived Antimicrobial Peptides as Potential Anti-Neoplastic Agents: New Insight into Anticancer Mechanisms of Stem Cells and Exosomes, Frontiers in Cell and Developmental Biology, 10, 2022. Crossref

  13. Banerjee Souvik, Chakraborty Soham, Majumder Kaustav, Rational design of bioactive chimeric construct by exploring archaeal antimicrobial peptides: an in silico approach, Biologia, 77, 8, 2022. Crossref

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