Publication de 6 numéros par an
ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472
IF:
1.3
5-Year IF:
2.6
Eigenfactor:
0.00079
JCI:
0.24
SJR:
0.429
SNIP:
0.287
CiteScore™::
2.7
H-Index:
81
Indexed in
CD40 Signaling to the Rescue: A CD8 Exhaustion Perspective in Chronic Infectious Diseases
Get access
RÉSUMÉ
Chronic infectious diseases such as HIV, HBV, and HCV, among others, cause severe morbidity and mortality globally. Progressive decline in CD8 functionality, survival, and proliferative potential-a phenomenon referred to as CD8 exhaustion-is believed to be responsible for poor pathogen control in chronic infectious diseases. While the role of negative inhibitory receptors such as PD−1 in augmenting CD8 exhaustion has been extensively studied, the role of positive costimulatory receptors remains poorly understood. In this review, we discuss how one such costimulatory pathway, CD40−CD40L, regulates CD8 dysfunction and rescue. While the significance of this pathway has been extensively investigated in models of autoimmunity, acute infectious diseases, and tumor models, the role played by CD40−CD40L in regulating CD8 exhaustion in chronic infectious diseases is just beginning to be understood. Considering that monotherapy with blocking antibodies targeting inhibitory PD−1−PD−L1 pathway is only partially effective at ameliorating CD8 exhaustion and that humanized CD40 agonist antibodies are currently available, a better understanding of the role of the CD40−CD40L pathway in chronic infectious diseases will pave the way for the development of more robust immunotherapeutic and prophylactic vaccination strategies.
-
Krishnamurthy Shruthi, Konstantinou Eleni K., Young Lucy H., Gold Daniel A., Saeij Jeroen P. J., Knoll Laura J, The human immune response to Toxoplasma: Autophagy versus cell death, PLOS Pathogens, 13, 3, 2017. Crossref
-
Khan Imtiaz A., Hwang SuJin, Moretto Magali, Toxoplasma gondii: CD8 T Cells Cry for CD4 Help, Frontiers in Cellular and Infection Microbiology, 9, 2019. Crossref
-
Pandey Madhu S., Wang Chunlei, Umlauf Scott, Lin Shihua, Simultaneous Inhibition of PD-1 and Stimulation of CD40 Signaling Pathways by Anti-PD-L1/CD40L Bispecific Fusion Protein Synergistically Activate Target and Effector Cells, International Journal of Molecular Sciences, 22, 21, 2021. Crossref
-
Širvinskas Dovydas, Omrani Omid, Lu Jing, Rasa Mahdi, Krepelova Anna, Adam Lisa, Kaeppel Sandra, Sommer Felix, Neri Francesco, Single-cell atlas of the aging mouse colon, iScience, 25, 5, 2022. Crossref
-
Prieto Jesús, Melero Ignacio, Sangro Bruno, Immunological landscape and immunotherapy of hepatocellular carcinoma, Nature Reviews Gastroenterology & Hepatology, 12, 12, 2015. Crossref
-
Feng Hai, Zhuo Yunhui, Zhang Xuemei, Li Yuyao, Li Yue, Duan Xiangjuan, Shi Jia, Xu Chengbin, Gao Yueqiu, Yu Zhuo, Tumor Microenvironment in Hepatocellular Carcinoma: Key Players for Immunotherapy, Journal of Hepatocellular Carcinoma, Volume 9, 2022. Crossref
-
Voynova Elisaveta, Mahmoud Tamer, Woods Lucas T., Weisman Gary A., Ettinger Rachel, Braley-Mullen Helen, Requirement for CD40/CD40L Interactions for Development of Autoimmunity Differs Depending on Specific Checkpoint and Costimulatory Pathways, ImmunoHorizons, 2, 1, 2018. Crossref