Publication de 6 numéros par an
ISSN Imprimer: 1040-8401
ISSN En ligne: 2162-6472
Indexed in
Dimethyl Fumarate Modulation of Immune and Antioxidant Responses: Application to HIV Therapy
RÉSUMÉ
The persistence of chronic immune activation and oxidative stress in human immunodeficiency virus (HIV)-infected, antiretroviral drug-treated individuals are major obstacles to fully preventing HIV disease progression. The immune modulator and antioxidant dimethyl fumarate (DMF) is effective in treating immune-mediated diseases and it also has potential applications to limiting HIV disease progression. Among the relevant effects of DMF and its active metabolite monomethyl fumarate (MMF) are induction of a Th1 to Th2 lymphocyte shift, inhibition of pro-inflammatory cytokine signaling, inhibition of NF-κB nuclear translocation, inhibition of dendritic cell maturation, suppression of lymphocyte and endothelial cell adhesion molecule expression, and induction of the Nrf2-dependent antioxidant response element (ARE) and effector genes. Associated with these effects are reduced lymphocyte and monocyte infiltration into psoriatic skin lesions in humans and immune-mediated demyelinating brain lesions in rodents, which confirms potent systemic and central nervous system (CNS) effects. In addition, DMF and MMF limit HIV infection in macrophages in vitro, albeit by unknown mechanisms. Finally, DMF and MMF also suppress neurotoxin production from HIV-infected macrophages, which drives CNS neurodegeneration. Thus, DMF might protect against systemic and CNS complications in HIV infection through its effective suppression of immune activation, oxidative stress, HIV replication, and macrophage-associated neuronal injury.
-
Gill Alexander J., Kovacsics Colleen E., Cross Stephanie A., Vance Patricia J., Kolson Lorraine L., Jordan-Sciutto Kelly L., Gelman Benjamin B., Kolson Dennis L., Heme oxygenase-1 deficiency accompanies neuropathogenesis of HIV-associated neurocognitive disorders, Journal of Clinical Investigation, 124, 10, 2014. Crossref
-
Nau Roland, Ribes Sandra, Djukic Marija, Eiffert Helmut, Strategies to increase the activity of microglia as efficient protectors of the brain against infections, Frontiers in Cellular Neuroscience, 8, 2014. Crossref
-
Hybertson B. M., Gao B., Role of the Nrf2 signaling system in health and disease, Clinical Genetics, 86, 5, 2014. Crossref
-
Xie Xin, Zhao Yu, Ma Chun-Yan, Xu Xiao-Ming, Zhang Yan-Qiu, Wang Chen-Guang, Jin Jing, Shen Xin, Gao Jin-Lai, Li Na, Sun Zhi-Jie, Dong De-Li, Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, British Journal of Pharmacology, 172, 15, 2015. Crossref
-
Das Ratul Kumar, Brar Satinder Kaur, Verma Mausam, Recent advances in the biomedical applications of fumaric acid and its ester derivatives: The multifaceted alternative therapeutics, Pharmacological Reports, 68, 2, 2016. Crossref
-
McGuire Victoria A., Ruiz-Zorrilla Diez Tamara, Emmerich Christoph H., Strickson Sam, Ritorto Maria Stella, Sutavani Ruhcha V., Weiβ Anne, Houslay Kirsty F., Knebel Axel, Meakin Paul J., Phair Iain R., Ashford Michael L. J., Trost Matthias, Arthur J. Simon C., Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation, Scientific Reports, 6, 1, 2016. Crossref
-
Huq Redwan, Samuel Errol L. G., Sikkema William K. A., Nilewski Lizanne G., Lee Thomas, Tanner Mark R., Khan Fatima S., Porter Paul C., Tajhya Rajeev B., Patel Rutvik S., Inoue Taeko, Pautler Robia G., Corry David B., Tour James M., Beeton Christine, Preferential uptake of antioxidant carbon nanoparticles by T lymphocytes for immunomodulation, Scientific Reports, 6, 1, 2016. Crossref
-
Ahmed Syed Minhaj Uddin, Luo Lin, Namani Akhileshwar, Wang Xiu Jun, Tang Xiuwen, Nrf2 signaling pathway: Pivotal roles in inflammation, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1863, 2, 2017. Crossref
-
Zhang Wen-Xian, Zhao Jian-Hong, Ping Fu-Min, Liu Zhi-Jun, Gu Jun-Xia, Lu Xin-Qing, Effect of dimethyl fumarate on rats with chronic pancreatitis, Asian Pacific Journal of Tropical Medicine, 9, 3, 2016. Crossref
-
Fiandra Luisa, Capetti Amedeo, Sorrentino Luca, Corsi Fabio, Nanoformulated Antiretrovirals for Penetration of the Central Nervous System: State of the Art, Journal of Neuroimmune Pharmacology, 12, 1, 2017. Crossref
-
Romano I, Summa M, Heredia-Guerrero J A, Spanò R, Ceseracciu L, Pignatelli C, Bertorelli R, Mele E, Athanassiou A, Fumarate-loaded electrospun nanofibers with anti-inflammatory activity for fast recovery of mild skin burns, Biomedical Materials, 11, 4, 2016. Crossref
-
Loboda Agnieszka, Damulewicz Milena, Pyza Elzbieta, Jozkowicz Alicja, Dulak Jozef, Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism, Cellular and Molecular Life Sciences, 73, 17, 2016. Crossref
-
Lu Meng-Chen, Ji Jian-Ai, Jiang Zheng-Yu, You Qi-Dong, The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update, Medicinal Research Reviews, 36, 5, 2016. Crossref
-
Fiedler Sarah E., Kerns Amelia R., Tsang Catherine, Love Haley N., Salinthone Sonemany, Donor variability may mask dimethyl fumarate’s effects on nuclear factor E2-related factor 2 in human peripheral blood mononuclear cells, BMC Research Notes, 10, 1, 2017. Crossref
-
Stojić-Vukanić Zorica, Kotur-Stevuljević Jelena, Nacka-Aleksić Mirjana, Kosec Duško, Vujnović Ivana, Pilipović Ivan, Dimitrijević Mirjana, Leposavić Gordana, Sex Bias in Pathogenesis of Autoimmune Neuroinflammation: Relevance for Dimethyl Fumarate Immunomodulatory/Anti-oxidant Action, Molecular Neurobiology, 2017. Crossref
-
Mastrantonio Roberta, Cervelli Manuela, Pietropaoli Stefano, Mariottini Paolo, Colasanti Marco, Persichini Tiziana, Cuzzocrea Salvatore, HIV-Tat Induces the Nrf2/ARE Pathway through NMDA Receptor-Elicited Spermine Oxidase Activation in Human Neuroblastoma Cells, PLOS ONE, 11, 2, 2016. Crossref
-
Pace Betty S, Liu Li, Li Biaoru, Makala Levi H, Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease, Experimental Biology and Medicine, 240, 8, 2015. Crossref
-
Cantres-Rosario Yisel M., Acevedo-Mariani Frances M., Pérez-Laspiur Juliana, Haskins William E., Plaud Marines, Cantres-Rosario Yadira M., Skolasky Richard, Méndez-Bermúdez Israel, Wojna Valerie, Meléndez Loyda M., Winston Alan, Microwave & magnetic proteomics of macrophages from patients with HIV-associated cognitive impairment, PLOS ONE, 12, 7, 2017. Crossref
-
Benedetti Francesca, Curreli Sabrina, Krishnan Selvi, Davinelli Sergio, Cocchi Fiorenza, Scapagnini Giovanni, Gallo Robert C., Zella Davide, Anti-inflammatory effects of H2S during acute bacterial infection: a review, Journal of Translational Medicine, 15, 1, 2017. Crossref
-
Southwood Cherie M., Garshott Danielle M., Richardson Chelsea R., Seraji-Bozorgzad Navid, Fribley Andrew M., Gow Alexander, Dimethyl fumarate ameliorates myoclonus stemming from protein misfolding in oligodendrocytes, Journal of Neurochemistry, 142, 1, 2017. Crossref
-
Oehrl Stephanie, Olaru Florina, Kunze Anja, Maas Michael, Pezer Silvia, Schmitz Marc, Schäkel Knut, Controlling the pro-inflammatory function of 6-sulfo LacNAc (slan) dendritic cells with dimethylfumarate, Journal of Dermatological Science, 87, 3, 2017. Crossref
-
Han Jingjing, Ma Shoubao, Gong Huanle, Liu Shuangzhu, Lei Lei, Hu Bo, Xu Yang, Liu Haiyan, Wu Depei, Inhibition of Acute Graft-versus-Host Disease with Retention of Graft-versus-Tumor Effects by Dimethyl Fumarate, Frontiers in Immunology, 8, 2017. Crossref
-
Kim Hyunyoung, Thompson Jeremy, Ji Guangchen, Ganapathy Vadivel, Neugebauer Volker, Monomethyl fumarate inhibits pain behaviors and amygdala activity in a rat arthritis model, Pain, 158, 12, 2017. Crossref
-
Vavougios George, Zarogiannis Sotirios G., Doskas Triantafylos, The putative interplay between DJ-1/NRF2 and Dimethyl Fumarate: A potentially important pharmacological target, Multiple Sclerosis and Related Disorders, 21, 2018. Crossref
-
Rosario-Rodríguez Lester J., Colón Krystal, Borges-Vélez Gabriel, Negrón Karla, Meléndez Loyda M., Dimethyl Fumarate Prevents HIV-Induced Lysosomal Dysfunction and Cathepsin B Release from Macrophages, Journal of Neuroimmune Pharmacology, 13, 3, 2018. Crossref
-
Zarbato Graciela Freitas, de Souza Goldim Mariana Pereira, Giustina Amanda Della, Danielski Lucinéia Gainski, Mathias Khiany, Florentino Drielly, de Oliveira Junior Aloir Neri, da Rosa Naiana, Laurentino Ana Olivia, Trombetta Taina, Gomes Maria Luiza, Steckert Amanda Valnier, Moreira Ana Paula, Schuck Patricia Fernanda, Fortunato Jucelia Jeremias, Barichello Tatiana, Petronilho Fabricia, Dimethyl Fumarate Limits Neuroinflammation and Oxidative Stress and Improves Cognitive Impairment After Polymicrobial Sepsis, Neurotoxicity Research, 34, 3, 2018. Crossref
-
Wang Tingting, Liu Lingling, Chen Xuyong, Shen Yuqing, Lian Gaojian, Shah Nilay, Davidoff Andrew M, Yang Jun, Wang Ruoning, MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent, Cell Death & Disease, 9, 2, 2018. Crossref
-
Morris Gerwyn, Reiche Edna Maria Vissoci, Murru Andrea, Carvalho André F., Maes Michael, Berk Michael, Puri Basant K., Multiple Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways Explain the Frequent Presence of Depression in Multiple Sclerosis, Molecular Neurobiology, 55, 8, 2018. Crossref
-
Lian Gaojian, Gnanaprakasam JN Rashida, Wang Tingting, Wu Ruohan, Chen Xuyong, Liu Lingling, Shen Yuqing, Yang Mao, Yang Jun, Chen Ying, Vasiliou Vasilis, Cassel Teresa A, Green Douglas R, Liu Yusen, Fan Teresa WM, Wang Ruoning, Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation, eLife, 7, 2018. Crossref
-
Traub Jan, Traffehn Sarah, Ochs Jasmin, Häusser‐Kinzel Silke, Stephan Schirin, Scannevin Robert, Brück Wolfgang, Metz Imke, Weber Martin S., Dimethyl fumarate impairs differentiated B cells and fosters central nervous system integrity in treatment of multiple sclerosis, Brain Pathology, 29, 5, 2019. Crossref
-
Woodcock Chen-Shan Chen, Chan Stephen Y., The Search for Disease-Modifying Therapies in Pulmonary Hypertension, Journal of Cardiovascular Pharmacology and Therapeutics, 24, 4, 2019. Crossref
-
Mostafa Mohamed E., Shaaban Ahmed A., Salem Hatem A., Dimethylfumarate ameliorates hepatic injury and fibrosis induced by carbon tetrachloride, Chemico-Biological Interactions, 302, 2019. Crossref
-
Dalmau Josep, Dalakas Marinos C., Kolson Dennis L., Paul Friedemann, Zamvil Scott S., N2 year in review, Neurology - Neuroimmunology Neuroinflammation, 7, 1, 2020. Crossref
-
Das Mamali, Pandima Devi Kasi, The Beneficial Role of Natural Antioxidants in Alleviating Neuroinflammatory Disorders Including Neurodegeneration, in Plant Antioxidants and Health, 2021. Crossref
-
Mainardi Ilaria, Ferrò Maria Teresa, Gastaldi Matteo, Franciotta Diego, Cinque Paola, Acquisition of human immunodeficiency virus infection in a patient with multiple sclerosis: could these conditions positively influence each other’s course?, Journal of NeuroVirology, 26, 6, 2020. Crossref
-
Timpani Cara A., Rybalka Emma, Calming the (Cytokine) Storm: Dimethyl Fumarate as a Therapeutic Candidate for COVID-19, Pharmaceuticals, 14, 1, 2020. Crossref
-
Laselva Onofrio, Allegretta Caterina, Di Gioia Sante, Avolio Carlo, Conese Massimo, Anti-Inflammatory and Anti-Oxidant Effect of Dimethyl Fumarate in Cystic Fibrosis Bronchial Epithelial Cells, Cells, 10, 8, 2021. Crossref
-
Yang S.T., Zhang K., Zhang B., Huang H., Fumaric Acid, in Comprehensive Biotechnology, 2019. Crossref
-
Garcia-Mesa Yoelvis, Xu He N., Vance Patricia, Gruenewald Analise L., Garza Rolando, Midkiff Cecily, Alvarez-Hernandez Xavier, Irwin David J., Gill Alexander J., Kolson Dennis L., Dimethyl Fumarate, an Approved Multiple Sclerosis Treatment, Reduces Brain Oxidative Stress in SIV-Infected Rhesus Macaques: Potential Therapeutic Repurposing for HIV Neuroprotection, Antioxidants, 10, 3, 2021. Crossref
-
Emanuele Sonia, Celesia Adriana, D’Anneo Antonella, Lauricella Marianna, Carlisi Daniela, De Blasio Anna, Giuliano Michela, The Good and Bad of Nrf2: An Update in Cancer and New Perspectives in COVID-19, International Journal of Molecular Sciences, 22, 15, 2021. Crossref
-
Sánchez-García Francisco Javier, Pérez-Hernández Celia Angélica, Rodríguez-Murillo Miguel, Moreno-Altamirano María Maximina Bertha, The Role of Tricarboxylic Acid Cycle Metabolites in Viral Infections, Frontiers in Cellular and Infection Microbiology, 11, 2021. Crossref
-
Weston J. Kyle, Uetrecht Jack, Activation of Inflammasomes by Agents Causing Idiosyncratic Skin Reactions: A Possible Biomarker, Chemical Research in Toxicology, 27, 6, 2014. Crossref
-
Ge Yueting, Li Bowen, Yang Yuhui, Feng Chuanxing, Tang Xue, Shi Yonghui, Le Guowei, Sun Jin, Oxidized Pork Induces Disorders of Glucose Metabolism in Mice, Molecular Nutrition & Food Research, 65, 6, 2021. Crossref
-
Morris Gerwyn, Sominsky Luba, Walder Kenneth R., Berk Michael, Marx Wolfgang, Carvalho André F., Bortolasci Chiara C., Maes Michael, Puri Basant K., Inflammation and Nitro-oxidative Stress as Drivers of Endocannabinoid System Aberrations in Mood Disorders and Schizophrenia, Molecular Neurobiology, 59, 6, 2022. Crossref
-
Sander Willem J., Fourie Corinne, Sabiu Saheed, O'Neill Frans H., Pohl Carolina H., O'Neill Hester G., Reactive oxygen species as potential antiviral targets, Reviews in Medical Virology, 32, 1, 2022. Crossref
-
Das Mamali, Devi Kasi Pandima, The Beneficial Role of Natural Antioxidants in Alleviating Neuroinflammatory Disorders Including Neurodegeneration, in Plant Antioxidants and Health, 2022. Crossref
-
da Silva Ueveton Pimentel, de Sousa Bianca Lana, Agrizzi Ana Paula, Mantovani Hilário Cuquetto, Leite João Paulo Viana, Varejão Eduardo Vinícius Vieira, Extracts from Euphorbia heterophylla naturally grown in Brazil – Chemical constitution and bioactivities, South African Journal of Botany, 142, 2021. Crossref
-
Wijdeven Ruud H, Luijn Marvin M, Wierenga‐Wolf Annet F, Akkermans Jimmy J, Elsen Peter J, Hintzen Rogier Q, Neefjes Jacques, Chemical and genetic control of IFN γ‐induced MHCII expression , EMBO reports, 19, 9, 2018. Crossref
-
Evans Heather M., Schultz Destiny F., Boiman Adam J., McKell Melanie C., Qualls Joseph E., Deepe George S., Wormley Floyd L., Restraint of Fumarate Accrual by HIF-1α Preserves miR-27a-Mediated Limitation of Interleukin 10 during Infection of Macrophages by Histoplasma capsulatum, mBio, 12, 6, 2021. Crossref
-
Kobayashi Kunitoshi, Tomiki Hiroki, Inaba Yuji, Ichikawa Motoki, Kim Byung S., Koh Chang-Sung, Dimethyl fumarate suppresses Theiler’s murine encephalomyelitis virus-induced demyelinating disease by modifying the Nrf2-Keap1 pathway, International Immunology, 27, 7, 2015. Crossref
-
Sikora Fryderyk, Ochmian Ireneusz, Sobolewska Magdalena, Quality and Technological Properties of Flour with the Addition of Aesculus Hippocastanum and Castanea Sativa , Acta Universitatis Cibiniensis. Series E: Food Technology, 26, 1, 2022. Crossref
-
Kolson Dennis L., Developments in Neuroprotection for HIV-Associated Neurocognitive Disorders (HAND), Current HIV/AIDS Reports, 19, 5, 2022. Crossref