Publication de 6 numéros par an
ISSN Imprimer: 0743-4863
ISSN En ligne: 2162-660X
Indexed in
Pulsatile Drug-Delivery Systems
RÉSUMÉ
Delivery systems with a pulsatile-release pattern are receiving increasing interest for the development of drugs for which conventional controlled drug-release systems with a continuous release are not ideal. These drugs often have a high first-pass effect or special chronopharmacological needs. A pulsatile-release profile is characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Pulsatile drug-delivery systems can be classified into site-specific systems in which the drug is released at the desired site within the intestinal tract (e.g., the colon), or time-controlled devices in which the drug is released after a well-defined time period. Site-controlled release is usually controlled by environmental factors, like the pH or enzymes present in the intestinal tract, whereas the drug release from time-controlled systems is controlled primarily by the delivery system and, ideally, not by the environment. This review covers various single- and multipleunit oral pulsatile drug-delivery systems with an emphasis on time-controlled drug-release systems.
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Li Yuhui, Huang Guoyou, Zhang Xiaohui, Li Baoqiang, Chen Yongmei, Lu Tingli, Lu Tian Jian, Xu Feng, Magnetic Hydrogels and Their Potential Biomedical Applications, Advanced Functional Materials, 23, 6, 2013. Crossref
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Yang Rongbing, Gorelov Alexander V., Aldabbagh Fawaz, Carroll William M., Rochev Yury, An implantable thermoresponsive drug delivery system based on Peltier device, International Journal of Pharmaceutics, 447, 1-2, 2013. Crossref
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Maroni Alessandra, Zema Lucia, Loreti Giulia, Palugan Luca, Gazzaniga Andrea, Film coatings for oral pulsatile release, International Journal of Pharmaceutics, 457, 2, 2013. Crossref
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Zhang Wenji, Zhang Lina, Qu Xukai, Zhu Zhihong, Pan Yusheng, Guan Jin, Pan Weisan, In vitroandin vivoevaluations of a novel pulsed and controlled osmotic pump capsule, Drug Development and Industrial Pharmacy, 41, 2, 2015. Crossref
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Cetin Emel Oyku, Gundogdu Evren, Baspinar Yücel, Karasulu Ercument, Kirilmaz Levent, Novel application of Eudragit RL and cholesteryl oleyl carbonate to thermo-sensitive drug delivery system, Drug Development and Industrial Pharmacy, 39, 12, 2013. Crossref
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Zema L., Maroni A., Foppoli A., Palugan L., Sangalli M.E., Gazzaniga A., Different HPMC Viscosity Grades as Coating Agents for an Oral Time and/or Site‐Controlled Delivery System: An Investigation into the Mechanisms Governing Drug Release, Journal of Pharmaceutical Sciences, 96, 6, 2007. Crossref
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Jain Deepika, Raturi Richa, Jain Vikas, Bansal Praveen, Singh Ranjit, Recent technologies in pulsatile drug delivery systems, Biomatter, 1, 1, 2011. Crossref
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Umadevi S. K., Thiruganesh R., Suresh S., Reddy K. Bhaskar, Formulation and evaluation of chitosan microspheres of aceclofenac for colon-targeted drug delivery, Biopharmaceutics & Drug Disposition, 31, 7, 2010. Crossref
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Soontornworajit Boonchoy, Zhou Jing, Wang Yong, A hybrid particle–hydrogel composite for oligonucleotide-mediated pulsatile protein release, Soft Matter, 6, 17, 2010. Crossref
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Patil Sumit S, Shahiwala Aliasgar, Patented pulsatile drug delivery technologies for chronotherapy, Expert Opinion on Therapeutic Patents, 24, 8, 2014. Crossref
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Gil Sara, Mano João F., Magnetic composite biomaterials for tissue engineering, Biomater. Sci., 2, 6, 2014. Crossref
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Del Curto Maria Dorly, Palugan Luca, Foppoli Anastasia, Zema Lucia, Gazzaniga Andrea, Maroni Alessandra, Erodible Time‐Dependent Colon Delivery Systems with Improved Efficiency in Delaying the Onset of Drug Release, Journal of Pharmaceutical Sciences, 103, 11, 2014. Crossref
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You Chang, Liang Xuedan, Sun Jiabei, Sun Lin, Wang Yitao, Fan Tianyuan, Zheng Ying, Blends of hydrophobic and swelling agents in the swelling layer in the preparation of delayed-release pellets of a hydrophilic drug with low MW: Physicochemical characterizations and in-vivo evaluations, Asian Journal of Pharmaceutical Sciences, 9, 4, 2014. Crossref
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Verma Vivek, Balasubramanian K., Experimental and theoretical investigations of Lantana camara oil diffusion from polyacrylonitrile membrane for pulsatile drug delivery system, Materials Science and Engineering: C, 41, 2014. Crossref
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Soontornworajit Boonchoy, Srakaew Prangkamol, Naramitpanich Pajaree, Aptamer-gelatin composite for a trigger release system mediated by oligonucleotide hybridization, Journal of Biomaterials Science, Polymer Edition, 25, 18, 2014. Crossref
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Salunkhe Sachin S., Bhatia Neela M., Kulkarni Prathamesh A., Bhatia Manish S., Formulation Design of Time-Controlled Release Formulation Containing Antidiabetic Drugs, Journal of Pharmaceutical Innovation, 9, 3, 2014. Crossref
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Kaassis Abdessamad Y. A., Young Neil, Sano Naoko, Merchant Hamid A., Yu Deng-Guang, Chatterton Nicholas P., Williams Gareth R., Pulsatile drug release from electrospun poly(ethylene oxide)–sodium alginate blend nanofibres, J. Mater. Chem. B, 2, 10, 2014. Crossref
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Ashraf M. W., Tayyaba S., Nisar A., Afzulpurkar N., Bodhale D. W., Lomas T., Poyai A., Tuantranont A., Design, Fabrication and Analysis of Silicon Hollow Microneedles for Transdermal Drug Delivery System for Treatment of Hemodynamic Dysfunctions, Cardiovascular Engineering, 10, 3, 2010. Crossref
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Maroni Alessandra, Zema Lucia, Cerea Matteo, Sangalli Maria Edvige, Oral pulsatile drug delivery systems, Expert Opinion on Drug Delivery, 2, 5, 2005. Crossref
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Petr J, Chmelíková E, Krejčová T, Řehák D, Novotná B, Jílek F, Parthenogenetic Activation of Pig Oocytes Using Pulsatile Treatment with a Nitric Oxide Donor, Reproduction in Domestic Animals, 45, 3, 2008. Crossref
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Lin Shan-Yang, Li Mei-Jane, Lin Kung-Hsu, Hydrophilic excipients modulate the time lag of time-controlled disintegrating press-coated tablets, AAPS PharmSciTech, 5, 4, 2004. Crossref
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Taha Ehab I., Bioavailability assessment of hydroxymethylglutaryl coenzyme A reductase inhibitor utilizing pulsatile drug delivery system: a pilot study, Drug Delivery, 23, 7, 2016. Crossref
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Kurosu Michio, Multiple-delayed release formulation approach for the treatment of methicillin-resistantStaphylococcus aureus, Expert Opinion on Therapeutic Patents, 18, 11, 2008. Crossref
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Chen Mei-Ling, Lee Vincent H.L., Equivalence-by-Design: Targeting In Vivo Drug Delivery Profile, Pharmaceutical Research, 25, 12, 2008. Crossref
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Ashraf Muhammad Waseem, Tayyaba Shahzadi, Afzulpurkar Nitin, Micro Electromechanical Systems (MEMS) Based Microfluidic Devices for Biomedical Applications, International Journal of Molecular Sciences, 12, 6, 2011. Crossref
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Xia Yujie, Pack Daniel W., Pulsatile Protein Release from Monodisperse Liquid-Core Microcapsules of Controllable Shell Thickness, Pharmaceutical Research, 31, 11, 2014. Crossref
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Gazzaniga Andrea, Maroni Alessandra, Sangalli Maria Edvige, Zema Lucia, Time-controlled oral delivery systems for colon targeting, Expert Opinion on Drug Delivery, 3, 5, 2006. Crossref
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Bussemer T, Bodmeier R, Formulation parameters affecting the performance of coated gelatin capsules with pulsatile release profiles, International Journal of Pharmaceutics, 267, 1-2, 2003. Crossref
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Gazzaniga Andrea, Palugan Luca, Foppoli Anastasia, Sangalli Maria Edvige, Oral pulsatile delivery systems based on swellable hydrophilic polymers, European Journal of Pharmaceutics and Biopharmaceutics, 68, 1, 2008. Crossref
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Maroni Alessandra, Zema Lucia, Curto Maria Dorly Del, Loreti Giulia, Gazzaniga Andrea, Oral pulsatile delivery: Rationale and chronopharmaceutical formulations, International Journal of Pharmaceutics, 398, 1-2, 2010. Crossref
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Sangalli M.E, Maroni A, Foppoli A, Zema L, Giordano F, Gazzaniga A, Different HPMC viscosity grades as coating agents for an oral time and/or site-controlled delivery system: a study on process parameters and in vitro performances, European Journal of Pharmaceutical Sciences, 22, 5, 2004. Crossref
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El-Maradny Hoda A., Modulation of a Pulsatile Release Drug Delivery System Using Different Swellable/Rupturable Materials, Drug Delivery, 14, 8, 2007. Crossref
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Wu Li, Wang Jiasi, Gao Nan, Ren Jinsong, Zhao Andong, Qu Xiaogang, Electrically pulsatile responsive drug delivery platform for treatment of Alzheimer’s disease, Nano Research, 8, 7, 2015. Crossref
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Taha Ehab I., Design and <i>in Vitro</i> Evaluation of Eudragit<sup>®</sup> S100/Lipid Based Simvastatin Chronotherapeutic Drug Delivery System, Pharmacology & Pharmacy, 05, 13, 2014. Crossref
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Atyabi F., Khodaverdi E., Dinarvand R., Temperature modulated drug permeation through liquid crystal embedded cellulose membranes, International Journal of Pharmaceutics, 339, 1-2, 2007. Crossref
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Dashevsky Andrei, Mohamad Ahmad, Development of pulsatile multiparticulate drug delivery system coated with aqueous dispersion Aquacoat® ECD, International Journal of Pharmaceutics, 318, 1-2, 2006. Crossref
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Hung Sheng-Feng, Hsieh Chien-Ming, Chen Ying-Chen, Lin Cheng-Mao, Ho Hsiu-O, Sheu Ming-Thau, Formulation and process optimization of multiparticulate pulsatile system delivered by osmotic pressure-activated rupturable membrane, International Journal of Pharmaceutics, 480, 1-2, 2015. Crossref
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Maroni Alessandra, Zema Lucia, Del Curto Maria Dorly, Foppoli Anastasia, Gazzaniga Andrea, Oral colon delivery of insulin with the aid of functional adjuvants, Advanced Drug Delivery Reviews, 64, 6, 2012. Crossref
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Gazzaniga Andrea, Cerea Matteo, Cozzi Alberto, Foppoli Anastasia, Maroni Alessandra, Zema Lucia, A Novel Injection-Molded Capsular Device for Oral Pulsatile Delivery Based on Swellable/Erodible Polymers, AAPS PharmSciTech, 12, 1, 2011. Crossref
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Sungthongjeen Srisagul, Puttipipatkhachorn Satit, Paeratakul Ornlaksana, Dashevsky Andrei, Bodmeier Roland, Development of pulsatile release tablets with swelling and rupturable layers, Journal of Controlled Release, 95, 2, 2004. Crossref
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Pinto João F., Site-specific drug delivery systems within the gastro-intestinal tract: From the mouth to the colon, International Journal of Pharmaceutics, 395, 1-2, 2010. Crossref
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Schellekens R.C.A., Stellaard F., Mitrovic D., Stuurman F.E., Kosterink J.G.W., Frijlink H.W., Pulsatile drug delivery to ileo-colonic segments by structured incorporation of disintegrants in pH-responsive polymer coatings, Journal of Controlled Release, 132, 2, 2008. Crossref
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Alakhov Valery, Pietrzynski Grzegorz, Patel Kishore, Kabanov Alexander, Bromberg Lev, Hatton T Alan, Pluronic block copolymers and Pluronic poly(acrylic acid) microgels in oral delivery of megestrol acetate, Journal of Pharmacy and Pharmacology, 56, 10, 2010. Crossref
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Bussemer T., Peppas N.A., Bodmeier R., Evaluation of the swelling, hydration and rupturing properties of the swelling layer of a rupturable pulsatile drug delivery system, European Journal of Pharmaceutics and Biopharmaceutics, 56, 2, 2003. Crossref
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Löbenberg Raimar, Kim Jae Seung, Amidon Gordon L., Pharmacokinetics of an immediate release, a controlled release and a two pulse dosage form in dogs, European Journal of Pharmaceutics and Biopharmaceutics, 60, 1, 2005. Crossref
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Jagdale Swati C., Chede Sachin M., Gulwady Ram, Kuchekar Bhanudas S., Lokhande Pradeep D., Shah Tejas P., Chabukswar Anuruddha R., Pulsatile multiparticulate drug delivery system for metoprolol succinate, Archives of Pharmacal Research, 34, 3, 2011. Crossref
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Shukla Dali, Chakraborty Subhashis, Singh Sanjay, Mishra Brahmeshwar, Pastillation: A novel technology for development of oral lipid based multiparticulate controlled release formulation, Powder Technology, 209, 1-3, 2011. Crossref
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Paulino Alexandre T., Guilherme Marcos R., Mattoso Luiz H. C., Tambourgi Elias B., Smart Hydrogels Based on Modified Gum Arabic as a Potential Device for Magnetic Biomaterial, Macromolecular Chemistry and Physics, 211, 11, 2010. Crossref
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Intra Janjira, Glasgow Justin M., Mai Hoang Q., Salem Aliasger K., Pulsatile release of biomolecules from polydimethylsiloxane (PDMS) chips with hydrolytically degradable seals, Journal of Controlled Release, 127, 3, 2008. Crossref
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Saisivam S., Rahamath Ulla M., Shakeel F., Development of Floating Matrix Tablets of Losartan Potassium: In Vitro and in Vivo Evaluation, Journal of Drug Delivery Science and Technology, 23, 6, 2013. Crossref
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Campardelli Roberta, Della Porta Giovanna, Gomez Leyre, Irusta Silvia, Reverchon Ernesto, Santamaria Jesus, Au–PLA nanocomposites for photothermally controlled drug delivery, J. Mater. Chem. B, 2, 4, 2014. Crossref
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Tran Toan, Hernandez Mariana, Patel Dhruvil, Wu Ji, Temperature and pH Responsive Microfibers for Controllable and Variable Ibuprofen Delivery, Advances in Materials Science and Engineering, 2015, 2015. Crossref
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Bussemer T., Dashevsky A., Bodmeier R., A pulsatile drug delivery system based on rupturable coated hard gelatin capsules, Journal of Controlled Release, 93, 3, 2003. Crossref
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Youan Bi-Botti C., Chronopharmaceutics: gimmick or clinically relevant approach to drug delivery?, Journal of Controlled Release, 98, 3, 2004. Crossref
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El-Malah Yasser, Nazzal Sami, Hydrophilic matrices: Application of Placket–Burman screening design to model the effect of POLYOX–carbopol blends on drug release, International Journal of Pharmaceutics, 309, 1-2, 2006. Crossref
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Lin Shan-Yang, Kawashima Yoshiaki, Current status and approaches to developing press-coated chronodelivery drug systems, Journal of Controlled Release, 157, 3, 2012. Crossref
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Patadia Riddhish, Vora Chintan, Mittal Karan, Mashru Rajashree C., Quality by Design Empowered Development and Optimisation of Time-Controlled Pulsatile Release Platform Formulation Employing Compression Coating Technology, AAPS PharmSciTech, 18, 4, 2017. Crossref
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Dashevsky A., Bussemer T., Mohamad A., Bodmeier R., Process and Formulation Variables Affecting the Performance of a Rupturable Capsule‐Based Drug Delivery System with Pulsatile Drug Release, Drug Development and Industrial Pharmacy, 30, 2, 2004. Crossref
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Kotagale Nandkishor, Maniyar Mithun, Somvanshi Sachin, Umekar Milind, Patel Chirag J, Eudragit-S, Eudragit-L and cellulose acetate phthalate coated polysaccharide tablets for colonic targeted delivery of azathioprine, Pharmaceutical Development and Technology, 15, 4, 2010. Crossref
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Figueroa-Ochoa Edgar. B., Villar-Alvarez Eva M., Cambón Adriana, Mistry Dharmista, Llovo José, Attwood David, Barbosa Silvia, Soltero J.F.Armando, Taboada Pablo, Lenghty reverse poly(butylene oxide)-poly(ethylene oxide)-poly(butylene oxide) polymeric micelles and gels for sustained release of antifungal drugs, International Journal of Pharmaceutics, 510, 1, 2016. Crossref
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Yu Tao, Chisholm Jane, Choi Woo Jin, Anonuevo Abraham, Pulicare Sarah, Zhong Weixi, Chen Minmin, Fridley Colleen, Lai Samuel K., Ensign Laura M., Suk Jung Soo, Hanes Justin, Mucus-Penetrating Nanosuspensions for Enhanced Delivery of Poorly Soluble Drugs to Mucosal Surfaces, Advanced Healthcare Materials, 5, 21, 2016. Crossref
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Jung Yunjin, Kim Young Mi, What should be considered on design of a colon-specific prodrug?, Expert Opinion on Drug Delivery, 7, 2, 2010. Crossref
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Che Rose Laili, Bear Joseph C., Southern Paul, McNaughter Paul D., Piggott R. Ben, Parkin Ivan P., Qi Sheng, Hills Brian P., Mayes Andrew G., On-demand, magnetic hyperthermia-triggered drug delivery: optimisation for the GI tract, Journal of Materials Chemistry B, 4, 9, 2016. Crossref
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Bussemer T., Peppas N. A., Bodmeier R., Time-Dependent Mechanical Properties of Polymeric Coatings Used in Rupturable Pulsatile Release Dosage Forms, Drug Development and Industrial Pharmacy, 29, 6, 2003. Crossref
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Varshosaz J., Jaffarian Dehkordi A., Golafshan S., Colon-specific delivery of mesalazine chitosan microspheres, Journal of Microencapsulation, 23, 3, 2006. Crossref
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Dabhi Chandu, Randale Shivsagar, Belgamwar Veena, Gattani Surendra, Tekade Avinash, Predictable pulsatile release of tramadol hydrochloride for chronotherapeutics of arthritis, Drug Delivery, 17, 5, 2010. Crossref
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Hammann Felix, Kummer Oliver, Guercioni Stefania, Imanidis Georgios, Drewe Juergen, Time controlled pulsatile transdermal delivery of nicotine: A phase I feasibility trial in male smokers, Journal of Controlled Release, 232, 2016. Crossref
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Mohamad A., Dashevsky A., In Vitro and In Vivo Performance of a Multiparticulate Pulsatile Drug Delivery System, Drug Development and Industrial Pharmacy, 33, 2, 2007. Crossref
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Patel Mayur M., Shah Tejal J., Amin Avani F., Shah Nitesh N., Design, Development and Optimization of a Novel Time and pH-Dependent Colon Targeted Drug Delivery System, Pharmaceutical Development and Technology, 14, 1, 2009. Crossref
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Seoane-Vazquez Enrique, Rodriguez-Monguio Rosa, Hansen Richard, Interchangeability, Safety and Efficacy of Modified-Release Drug Formulations in the USA: The Case of Opioid and Other Nervous System Drugs, Clinical Drug Investigation, 36, 4, 2016. Crossref
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Bajpai S.K., Singh Surinderpal, Bajpai M., Carbohydrate Polymers: Colon-Targeted Drug Delivery, in Encyclopedia of Biomedical Polymers and Polymeric Biomaterials, 2016. Crossref
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Li Wei, Wu Yuehan, Luo Xiaogang, Liu Shilin, Magnetic Bionanocomposites, in Bionanocomposites, 2017. Crossref
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Lim Dong-Jin, Park Hansoo, Near-infrared light for on-demand drug delivery, Journal of Biomaterials Science, Polymer Edition, 29, 7-9, 2018. Crossref
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Xu Jin, Lin Yiqing, Boulas Pierre, Peterson Matthew L., Low colonic absorption drugs: risks and opportunities in the development of oral extended release products, Expert Opinion on Drug Delivery, 15, 2, 2018. Crossref
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Isakova Anna, Novakovic Katarina, Oscillatory chemical reactions in the quest for rhythmic motion of smart materials, European Polymer Journal, 95, 2017. Crossref
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Chen Yuanfen, Jamshidi Reihaneh, Hong Wangyujue, Montazami Reza, Interfacial Stress in Physically Transient Layered Structures: An Experimental and Analytical Approach, Advanced Materials Interfaces, 4, 7, 2017. Crossref
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Conte Raffaele, De Luise Adriana, Valentino Anna, Di Cristo Francesca, Petillo Orsolina, Riccitiello Francesco, Di Salle Anna, Calarco Anna, Peluso Gianfranco, Hydrogel Nanocomposite Systems, in Nanocarriers for Drug Delivery, 2019. Crossref
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Kumari Amrita, Jain Ankit, Hurkat Pooja, Tiwari Ankita, Jain Sanjay K., Eudragit S100 coated microsponges for Colon targeting of prednisolone, Drug Development and Industrial Pharmacy, 44, 6, 2018. Crossref
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Thapaliya Rocky, Shrestha Kailash, Sharma Asmita, Dhakal Neelam, Manandhar Pragya, Shrestha Sahana, Bhattarai Ravi, Physicochemical characterization of naproxen microcrystals for colon specific pulsatile drug delivery designed using pulsincap technique, Journal of Pharmaceutical Investigation, 49, 5, 2019. Crossref
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Lu Chun-Hua, Qi Xiu-Juan, Li Juan, Yang Huang-Hao, Aptamer-Based Hydrogels and Their Applications, in Aptamers Selected by Cell-SELEX for Theranostics, 2015. Crossref
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Satarkar Nitin S., Hawkins Ashley M., Hilt J. Zach, Hydrogel Nanocomposites in Biology and Medicine: Applications and Interactions, in Biological Interactions on Materials Surfaces, 2009. Crossref
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Foppoli Anastasia, Cerea Matteo, Palugan Luca, Zema Lucia, Melocchi Alice, Maroni Alessandra, Gazzaniga Andrea, Evaluation of powder-layering vs. spray-coating techniques in the manufacturing of a swellable/erodible pulsatile delivery system, Drug Development and Industrial Pharmacy, 46, 8, 2020. Crossref
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Palugan Luca, Filippin Ilaria, Cirilli Micol, Moutaharrik Saliha, Zema Lucia, Cerea Matteo, Maroni Alessandra, Foppoli Anastasia, Gazzaniga Andrea, Cellulase as an “active” excipient in prolonged-release HPMC matrices: A novel strategy towards zero-order release kinetics, International Journal of Pharmaceutics, 607, 2021. Crossref
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Kurakula Mallesh, Raghavendra Naveen N., Electrospraying: A facile technology unfolding the chitosan based drug delivery and biomedical applications, European Polymer Journal, 147, 2021. Crossref
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Timucin Ugurlu, Mini Tablets: A Short Review-Revision, Open Journal of Chemistry, 2017. Crossref
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Kenjale Prathmesh, Pokharkar Varsha, Risk Assessment and QbD-Based Optimization of Sorafenib Tosylate Colon Targeted Bilayer Tablet: In Vitro Characterization, In Vivo Pharmacokinetic, and In Vivo Roentgenography Studies, AAPS PharmSciTech, 23, 6, 2022. Crossref
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Barouti Ghislaine, Jaffredo Cédric G., Guillaume Sophie M., Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers, Progress in Polymer Science, 73, 2017. Crossref
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Singh Prabha, Waghambare Pramita, Khan Tabassum Asif, Omri Abdelwahab, Colorectal cancer management: strategies in drug delivery, Expert Opinion on Drug Delivery, 19, 6, 2022. Crossref
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Kaljević Olivera, Djuriš Jelena, Djurić Zorica, Ibrić Svetlana, Application of failure mode and effects analysis in quality by design approach for formulation of carvedilol compression coated tablets, Journal of Drug Delivery Science and Technology, 32, 2016. Crossref