Publication de 4 numéros par an
ISSN Imprimer: 0893-9675
ISSN En ligne: 2162-6448
Indexed in
DNA Methylation in Radiation-Induced Carcinogenesis: Experimental Evidence and Clinical Perspectives
RÉSUMÉ
Ionizing radiation is a valuable tool in many spheres of human life. At the same time, it is a genotoxic agent with a well-established carcinogenic potential. Progress achieved in the last two decades has demonstrated convincingly that ionizing radiation can also target the cellular epigenome. Epigenetics is defined as heritable changes in the expression of genes that are not due to alterations of DNA sequence but consist of specific covalent modifications of chromatin components, such as methylation of DNA, histone modifications, and control performed by non-coding RNAs. Accumulating evidence suggests that DNA methylation, a key epigenetic mechanism involved in the control of expression of genetic information, may serve as one of the driving mechanisms of radiation-induced carcinogenesis. Here, we review the literature on the effects of ionizing radiation on DNA methylation in various biological systems, discuss the role of DNA methylation in radiation carcinogenesis, and provide our opinion on the potential utilization of this knowledge in radiation oncology.
-
Lou Dan, Wei Xiaoyi, Xiao Ping, Huo Qian, Hong Xinyu, Sun Jingqiu, Shuai Yi, Tao Gonghua, Demethylation of the NRF2 Promoter Protects Against Carcinogenesis Induced by Nano-SiO2, Frontiers in Genetics, 11, 2020. Crossref
-
Brun Vegard Heimly, Knutsen Erik, Stenvold Helge, Halvorsen Hanne, Severe hypercalcemia caused by parathyroid hormone in a rectal cancer metastasis: a case report, BMC Endocrine Disorders, 21, 1, 2021. Crossref
-
Belli Mauro, Indovina Luca, The Response of Living Organisms to Low Radiation Environment and Its Implications in Radiation Protection, Frontiers in Public Health, 8, 2020. Crossref
-
Priya Rashmi, Das Birajalaxmi, Global DNA methylation profile at LINE-1 repeats and promoter methylation of genes involved in DNA damage response and repair pathways in human peripheral blood mononuclear cells in response to γ-radiation, Molecular and Cellular Biochemistry, 477, 1, 2022. Crossref
-
Nwanaji‐Enwerem Jamaji C., Boileau Philippe, Galazka Jonathan M., Cardenas Andres, In vitro relationships of galactic cosmic radiation and epigenetic clocks in human bronchial epithelial cells, Environmental and Molecular Mutagenesis, 63, 4, 2022. Crossref