Publication de 4 numéros par an
ISSN Imprimer: 0893-9675
ISSN En ligne: 2162-6448
Indexed in
Survey of Raf Kinase Inhibitor Protein (RKIP) in Multiple Cancer Types
RÉSUMÉ
Raf kinase inhibitor protein (RKIP), an inhibitor of several signaling pathways, has been shown to have metastasis suppressor gene activity and promote apoptosis. While first identified in prostate cancer, RKIP's anti-metastasis properties have now been demonstrated in multiple tumor types. Furthermore, loss of RKIP expression is observed in many cancers as they progress. In this review, we provide a survey of the many tumor types in which RKIP function or expression has been evaluated. Particular attention is focused on the expression of RKIP in clinical tissues and its prognostic significance. A PubMed search through May 2014 identified 56 publications detailing RKIP expression in clinical cancer tissues. The majority of studies revealed that loss of RKIP expression has prognostic value for overall survival, disease free survival, and presence of metastasis for most solid tumor cancers; whereas, RKIP expression correlated with tumor grade or stage in approximately only 50% of the publications. In summary, RKIP loss is a frequent occurrence in many solid tumor cancers and may serve as a viable prognostic biomarker.
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Caraffini Veronica, Perfler Bianca, Berg Johannes Lorenz, Uhl Barbara, Schauer Silvia, Kashofer Karl, Ghaffari-Tabrizi-Wizsy Nassim, Strobl Herbert, Wölfler Albert, Hoefler Gerald, Sill Heinz, Zebisch Armin, Loss of RKIP is a frequent event in myeloid sarcoma and promotes leukemic tissue infiltration, Blood, 131, 7, 2018. Crossref
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Cardoso-Carneiro Diana, Raquel-Cunha Ana, Pinheiro Joana, Gabriela-Freitas Maria, Fontão Patrícia, Reis Rui M., Martinho Olga, Implications of RKIP protein in cancer prognosis and therapy response: A literature update, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref
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Gabriela-Freitas , Pinheiro , Raquel-Cunha , Cardoso-Carneiro , Martinho , RKIP as an Inflammatory and Immune System Modulator: Implications in Cancer, Biomolecules, 9, 12, 2019. Crossref
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Lin Wenlong, Wang Xiaojian, Role of RKIP in inflammatory responses, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref
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Ahmed Mahmoud, Kim Deok Ryong, Anti-cancer effect of RKIP via modulating autophagy during metastasis, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref
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Kashfi Khosrow, Zhou Yongxin, Corrente Gabrielle M., RKIP a master of regulatory pathways: Perspectives, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref
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Bonavida Benjamin, RKIP: A Pivotal Gene Product in the Pathogenesis of Cancer, Cancers, 13, 10, 2021. Crossref
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