Abonnement à la biblothèque: Guest
Critical Reviews™ in Oncogenesis

Publication de 4  numéros par an

ISSN Imprimer: 0893-9675

ISSN En ligne: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

Indexed in

Survey of Raf Kinase Inhibitor Protein (RKIP) in Multiple Cancer Types

Volume 19, Numéro 6, 2014, pp. 455-468
DOI: 10.1615/CritRevOncog.2014011987
Get accessGet access

RÉSUMÉ

Raf kinase inhibitor protein (RKIP), an inhibitor of several signaling pathways, has been shown to have metastasis suppressor gene activity and promote apoptosis. While first identified in prostate cancer, RKIP's anti-metastasis properties have now been demonstrated in multiple tumor types. Furthermore, loss of RKIP expression is observed in many cancers as they progress. In this review, we provide a survey of the many tumor types in which RKIP function or expression has been evaluated. Particular attention is focused on the expression of RKIP in clinical tissues and its prognostic significance. A PubMed search through May 2014 identified 56 publications detailing RKIP expression in clinical cancer tissues. The majority of studies revealed that loss of RKIP expression has prognostic value for overall survival, disease free survival, and presence of metastasis for most solid tumor cancers; whereas, RKIP expression correlated with tumor grade or stage in approximately only 50% of the publications. In summary, RKIP loss is a frequent occurrence in many solid tumor cancers and may serve as a viable prognostic biomarker.

CITÉ PAR
  1. Rajkumar Karthik, Nichita Aare, Anoor Pawan Kumar, Raju Swathi, Singh Surya Satyanarayana, Burgula Sandeepta, Understanding perspectives of signalling mechanisms regulating PEBP1 function, Cell Biochemistry and Function, 34, 6, 2016. Crossref

  2. Liu ShuYan, Li Xiao, Lin ZhaoMin, Su Le, Yan Shan, Zhao BaoXiang, Miao JunYing, SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis, Cancer Letters, 416, 2018. Crossref

  3. Shvartsur Anna, Givechian Kevin B., Garban Hermes, Bonavida Benjamin, Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma, Journal of Experimental & Clinical Cancer Research, 36, 1, 2017. Crossref

  4. Mendoza-Viveros Lucia, Cheng Hai-Ying Mary, PEBP-1, in Encyclopedia of Signaling Molecules, 2018. Crossref

  5. Mendoza-Viveros Lucia, Cheng Hai-Ying Mary, PEBP-1, in Encyclopedia of Signaling Molecules, 2016. Crossref

  6. Davalieva Katarina, Kiprijanovska Sanja, Maleva Kostovska Ivana, Stavridis Sotir, Stankov Oliver, Komina Selim, Petrusevska Gordana, Polenakovic Momir, Comparative Proteomics Analysis of Urine Reveals Down-Regulation of Acute Phase Response Signaling and LXR/RXR Activation Pathways in Prostate Cancer, Proteomes, 6, 1, 2017. Crossref

  7. Crassini Kyle, Pyke Tahni, Shen Yandong, Stevenson William S., Christopherson Richard I., Mulligan Stephen P., Best Oliver Giles, Inhibition of the Raf-1 kinase inhibitory protein (RKIP) by locostatin induces cell death and reduces the CXCR4-mediated migration of chronic lymphocytic leukemia cells, Leukemia & Lymphoma, 59, 12, 2018. Crossref

  8. Yesilkanal Ali, Rosner Marsha, Targeting Raf Kinase Inhibitory Protein Regulation and Function, Cancers, 10, 9, 2018. Crossref

  9. Caraffini Veronica, Perfler Bianca, Berg Johannes Lorenz, Uhl Barbara, Schauer Silvia, Kashofer Karl, Ghaffari-Tabrizi-Wizsy Nassim, Strobl Herbert, Wölfler Albert, Hoefler Gerald, Sill Heinz, Zebisch Armin, Loss of RKIP is a frequent event in myeloid sarcoma and promotes leukemic tissue infiltration, Blood, 131, 7, 2018. Crossref

  10. Kim Jin Sun, Choi Gwang Hyeon, Jung Yusun, Kim Kang Mo, Jang Se-Jin, Yu Eun Sil, Lee Han Chu, Downregulation of Raf-1 kinase inhibitory protein as a sorafenib resistance mechanism in hepatocellular carcinoma cell lines, Journal of Cancer Research and Clinical Oncology, 144, 8, 2018. Crossref

  11. Zaravinos Apostolos, Bonavida Benjamin, Chatzaki Ekaterini, Baritaki Stavroula, RKIP: A Key Regulator in Tumor Metastasis Initiation and Resistance to Apoptosis: Therapeutic Targeting and Impact, Cancers, 10, 9, 2018. Crossref

  12. Raquel-Cunha Ana, Cardoso-Carneiro Diana, Reis Rui M., Martinho Olga, Current Status of Raf Kinase Inhibitor Protein (RKIP) in Lung Cancer: Behind RTK Signaling, Cells, 8, 5, 2019. Crossref

  13. Zebisch Armin, Caraffini Veronica, Sill Heinz, RAF Kinase Inhibitor Protein in Myeloid Leukemogenesis, International Journal of Molecular Sciences, 20, 22, 2019. Crossref

  14. Man Ruo-Jun, Zhang Ya-Liang, Jiang Ai-Qin, Zhu Hai-Liang, A patent review of RAF kinase inhibitors (2010–2018), Expert Opinion on Therapeutic Patents, 29, 9, 2019. Crossref

  15. Schoentgen Françoise, Jonic Slavica, PEBP1/RKIP behavior: a mirror of actin-membrane organization, Cellular and Molecular Life Sciences, 77, 5, 2020. Crossref

  16. Noh Hae Sook, Hah Young-Sool, Ha Ji Hye, Kang Min Young, Zada Sahib, Rha Sun Young, Kang Sang Soo, Kim Hyun Joon, Park Jae-Yong, Byun June-Ho, Hahm Jong Ryeal, Shin Jeong Kyu, Jeong Sang-Ho, Lee Young-Joon, Kim Deok Ryong, Regulation of the epithelial to mesenchymal transition and metastasis by Raf kinase inhibitory protein-dependent Notch1 activity, Oncotarget, 7, 4, 2016. Crossref

  17. Rapozzi Valentina, Xodo Luigi Emilio, Role of RKIP in the tumor response to photooxidative damage, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref

  18. Schoentgen Francoise, Insight on the role of RKIP in cancer through key protein partners and cellular protrusions, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref

  19. Penas Cristina, Apraiz Aintzane, Muñoa Iraia, Arroyo-Berdugo Yoana, Rasero Javier, Ezkurra Pilar A., Velasco Veronica, Subiran Nerea, Bosserhoff Anja K., Alonso Santos, Asumendi Aintzane, Boyano Maria D., RKIP Regulates Differentiation-Related Features in Melanocytic Cells, Cancers, 12, 6, 2020. Crossref

  20. Cardoso-Carneiro Diana, Raquel-Cunha Ana, Pinheiro Joana, Gabriela-Freitas Maria, Fontão Patrícia, Reis Rui M., Martinho Olga, Implications of RKIP protein in cancer prognosis and therapy response: A literature update, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref

  21. Gabriela-Freitas , Pinheiro , Raquel-Cunha , Cardoso-Carneiro , Martinho , RKIP as an Inflammatory and Immune System Modulator: Implications in Cancer, Biomolecules, 9, 12, 2019. Crossref

  22. Lin Wenlong, Wang Xiaojian, Role of RKIP in inflammatory responses, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref

  23. Ahmed Mahmoud, Kim Deok Ryong, Anti-cancer effect of RKIP via modulating autophagy during metastasis, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref

  24. Kashfi Khosrow, Zhou Yongxin, Corrente Gabrielle M., RKIP a master of regulatory pathways: Perspectives, in Prognostic and Therapeutic Applications of RKIP in Cancer, 2020. Crossref

  25. Bonavida Benjamin, RKIP: A Pivotal Gene Product in the Pathogenesis of Cancer, Cancers, 13, 10, 2021. Crossref

  26. Parate Shraddha, Rampogu Shailima, Lee Gihwan, Hong Jong Chan, Lee Keun Woo, Exploring the Binding Interaction of Raf Kinase Inhibitory Protein With the N-Terminal of C-Raf Through Molecular Docking and Molecular Dynamics Simulation, Frontiers in Molecular Biosciences, 8, 2021. Crossref

  27. Dong Ying, Lin Xiaozeng, Kapoor Anil, Gu Yan, Xu Hui, Major Pierre, Tang Damu, Insights of RKIP-Derived Suppression of Prostate Cancer, Cancers, 13, 24, 2021. Crossref

  28. Periferakis Argyrios, Tsigas Georgios, Periferakis Aristodemos-Theodoros, Badarau Ioana Anca, Scheau Andreea-Elena, Tampa Mircea, Georgescu Simona Roxana, Didilescu Andreea Cristiana, Scheau Cristian, Caruntu Constantin, Morelli Maria Beatrice, Antitumoral and Anti-inflammatory Roles of Somatostatin and Its Analogs in Hepatocellular Carcinoma, Analytical Cellular Pathology, 2021, 2021. Crossref

  29. Lei Ting, Qian Hu, Lei Pengfei, Hu Yihe, Ferroptosis‐related gene signature associates with immunity and predicts prognosis accurately in patients with osteosarcoma, Cancer Science, 112, 11, 2021. Crossref

  30. Yesilkanal Ali Ekrem, Yang Dongbo, Valdespino Andrea, Tiwari Payal, Sabino Alan U, Nguyen Long Chi, Lee Jiyoung, Xie Xiao-He, Sun Siqi, Dann Christopher, Robinson-Mailman Lydia, Steinberg Ethan, Stuhlmiller Timothy, Frankenberger Casey, Goldsmith Elizabeth, Johnson Gary L, Ramos Alexandre F, Rosner Marsha R, Limited inhibition of multiple nodes in a driver network blocks metastasis, eLife, 10, 2021. Crossref

  31. Martinho Olga, Campos Marcelo, Ribeiro Guilherme, Penna Valter, Curcelli Emílio C., Olivieri Marcus V., Morini Sandra, Scapulatempo Cristovam, Abrahão-Machado Lucas F., Reis Rui M., Raf Kinase Inhibitor Protein Expression and Prognostic Value in Soft Tissue Sarcomas, Pathobiology, 83, 1, 2016. Crossref

  32. Giovanini Guilherme, Barros Luciana R. C., Gama Leonardo R., Tortelli Tharcisio C., Ramos Alexandre F., A Stochastic Binary Model for the Regulation of Gene Expression to Investigate Responses to Gene Therapy, Cancers, 14, 3, 2022. Crossref

  33. Hatzl Stefan, Geiger Olivia, Kuepper Maja Kim, Caraffini Veronica, Seime Till, Furlan Tobias, Nussbaumer Erika, Wieser Rotraud, Pichler Martin, Scheideler Marcel, Nowek Katarzyna, Jongen-Lavrencic Mojca, Quehenberger Franz, Wölfler Albert, Troppmair Jakob, Sill Heinz, Zebisch Armin, Increased Expression of miR-23a Mediates a Loss of Expression in the RAF Kinase Inhibitor Protein RKIP, Cancer Research, 76, 12, 2016. Crossref

  34. Lorenz Kristina, Rosner Marsha Rich, Harnessing RKIP to Combat Heart Disease and Cancer, Cancers, 14, 4, 2022. Crossref

  35. Vivarelli Silvia, Falzone Luca, Grillo Caterina Maria, Bonavida Benjamin, Crimi Claudia, La Mantia Ignazio, Libra Massimo, Computational Analyses of YY1 and Its Target RKIP Reveal Their Diagnostic and Prognostic Roles in Lung Cancer, Cancers, 14, 4, 2022. Crossref

Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections Prix et politiques d'abonnement Begell House Contactez-nous Language English 中文 Русский Português German French Spain