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Critical Reviews™ in Oncogenesis

Publication de 4  numéros par an

ISSN Imprimer: 0893-9675

ISSN En ligne: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Liquid Biopsies in the Management of Bladder Cancer: Next-Generation Biomarkers for Diagnosis, Surveillance, and Treatment-Response Prediction

Volume 22, Numéro 5-6, 2017, pp. 389-401
DOI: 10.1615/CritRevOncog.2017020803
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RÉSUMÉ

In this review, we discuss the types of liquid biopsies currently available, and their recent and potential clinical applications, especially as they relate to the detection of molecular biomarkers of bladder cancer. The advances in research using high-throughput next-generation genomic techniques have identified a number of promising molecular biomarkers of bladder urothelial carcinoma. Liquid biopsy has recently received enormous attention as a potential tool for real-time monitoring of disease status in cancer patients, and genomic profiles are reported to closely match those of corresponding tumors. It is noninvasive and easily repeated, and allows monitoring during treatment and detection of different genomic alterations that are potentially accessible to targeted therapy or are associated with treatment resistance in bladder cancer patients. Moreover, liquid biopsy is a tool that allows rapid access to biomarker assessment in patients for whom solid biopsies are not available. Liquid biopsy will be widely applied to daily clinical practice and serve as an important tool for the screening, surveillance, prediction of outcomes, and selection of effective targeted therapies in bladder carcinoma.

CITÉ PAR
  1. Kouba Erik, Lopez-Beltran Antonio, Montironi Rodolfo, Massari Francesco, Huang Kun, Santoni Matteo, Chovanec Michal, Cheng Michael, Scarpelli Marina, Zhang Jie, Cimadamore Alessia, Cheng Liang, Liquid biopsy in the clinical management of bladder cancer: current status and future developments, Expert Review of Molecular Diagnostics, 20, 2, 2020. Crossref

  2. Choi Jeong Uk, Park In-Kyu, Lee Yong-Kyu, Hwang Seung Rim, The Biological Function and Therapeutic Potential of Exosomes in Cancer: Exosomes as Efficient Nanocommunicators for Cancer Therapy, International Journal of Molecular Sciences, 21, 19, 2020. Crossref

  3. Lobo João, Monteiro-Reis Sara, Guimarães-Teixeira Catarina, Lopes Paula, Carneiro Isa, Jerónimo Carmen, Henrique Rui, Practicability of clinical application of bladder cancer molecular classification and additional value of epithelial-to-mesenchymal transition: prognostic value of vimentin expression, Journal of Translational Medicine, 18, 1, 2020. Crossref

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