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Critical Reviews™ in Oncogenesis

Publication de 4  numéros par an

ISSN Imprimer: 0893-9675

ISSN En ligne: 2162-6448

SJR: 0.395 SNIP: 0.322 CiteScore™:: 2.5 H-Index: 54

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Regulation of FAK Activity by Tetraspan Proteins: Potential Clinical Implications in Cancer

Volume 20, Numéro 5-6, 2015, pp. 391-405
DOI: 10.1615/CritRevOncog.v20.i5-6.110
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RÉSUMÉ

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that regulates multiple cell signaling pathways in both physiological and pathological conditions. Overexpression and activation of FAK is associated with many advanced stage cancers through promoting cancer cell tumorigenicity and progression as well as by regulating the tumor microenvironment. FAK has multiple binding partners through which FAK exerts its functions including RhoGEF, Src family, talin, cortactin, and paxilin. Over the last few years, it has been proposed that a novel group of four transmembrane proteins can interact with FAK and regulate its activity. These include select tetraspanins such as CD151 and CD9 as well as the GAS3 family members epithelial membrane protein-2 (EMP2) and peripheral myelin protein-22 (PMP22). In this review, we discuss the current knowledge of the interaction between FAK and tetraspan proteins in physiological and pathological conditions, with an emphasis on the potential of tetraspan family members as therapeutic targets in cancer.

CITÉ PAR
  1. Robert Jean-Michel H., Amoussou Nathalie Gisèle, Mai Hubert Le, Logé Cédric, Brouard Sophie, Tetraspanins: useful multifunction proteins for the possible design and development of small-molecule therapeutic tools, Drug Discovery Today, 26, 1, 2021. Crossref

  2. Malla Rama Rao, CD151: A Lateral Organizer and Modulator of Tumor Microenvironment in Gastrointestinal Cancers, in Novel therapeutic approaches for gastrointestinal malignancies, 2020. Crossref

  3. Wang Xiangmeng, Mak Po Yee, Mu Hong, Tao Wenjing, Rao Arvind, Visweswaran Ravikumar, Ruvolo Vivian, Pachter Jonathan A., Weaver David T., Andreeff Michael, Xu Bing, Carter Bing Z., Combinatorial Inhibition of Focal Adhesion Kinase and BCL-2 Enhances Antileukemia Activity of Venetoclax in Acute Myeloid Leukemia, Molecular Cancer Therapeutics, 19, 8, 2020. Crossref

  4. Zhang Nan, Zhu Hong‑Ping, Huang Wei, Wen Xiang, Xie Xin, Jiang Xian, Peng Cheng, Han Bo, He Gu, Unraveling the structures, functions and mechanisms of epithelial membrane protein family in human cancers, Experimental Hematology & Oncology, 11, 1, 2022. Crossref

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