Publication de 6 numéros par an
ISSN Imprimer: 0278-940X
ISSN En ligne: 1943-619X
Indexed in
Role of vascularity for successful bone formation and repair
RÉSUMÉ
Tissue engineering has been touted as the solution to regenerate tissue in patients. Yet current strategies for orthopedic application are limited because of the inability to successfully manage critical sized defects without a working vascular system. Bone grafts are commonly used in critical sized defects to fill the gap in missing bone tissue. Proper vasculature is vital to the success of these grafts to promote bone growth. The aim of this review is to describe the contribution of tissues surrounding critical sized defects, focusing in particular on the progenitor cell influx and factors contributing to neovascularization. An overview of clinical techniques to visualize patient vascular supply and evaluation of clinical techniques to increase blood flow to the critical defect site illustrates the current efforts of surgical intervention to promote proper bone formation. The opportunity and need lies in the development of tissue engineered bone grafts that can use and enhance available vascular supplies.
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Cavallo Marco, Maglio Melania, Parrilli Annapaola, Pagani Stefania, Martini Lucia, Castagnini Francesco, Rotini Roberto, Fini Milena, Vascular Supply and Bone Marrow Concentrate for the Improvement of Allograft in Bone Defects: A Comparative In Vivo Study, Journal of Surgical Research, 252, 2020. Crossref
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Xiang Junyu, Li Jianmei, He Jian, Tang Xiangyu, Dou Ce, Cao Zhen, Yu Bo, Zhao Chunrong, Kang Fei, Yang Lu, Dong Shiwu, Yang Xiaochao, Cerium Oxide Nanoparticle Modified Scaffold Interface Enhances Vascularization of Bone Grafts by Activating Calcium Channel of Mesenchymal Stem Cells, ACS Applied Materials & Interfaces, 8, 7, 2016. Crossref
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Zheng Jia-San, Ruan Hong-Ri, Shuang-Qiu , Jing-Nie , Hou Kai-Wen, Rui-Wu , Therapeutic effects of revascularisation on the healing of free bone grafts in dogs, Journal of Veterinary Research, 64, 1, 2020. Crossref
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Shi Cheng, Yuan Fei, Li Zhilong, Zheng Zhenhua, Yuan Changliang, Huang Ziyang, Liu Jianping, Lin Xuping, Cai Taoyi, Huang Guofeng, Ding Zhenqi, Wan Chunpeng, MSN@IL-4 Sustainingly Mediates Macrophagocyte M2 Polarization and Relieves Osteoblast Damage via NF-κB Pathway-Associated Apoptosis, BioMed Research International, 2022, 2022. Crossref