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ISSN Imprimer: 1947-5764

ISSN En ligne: 1947-5772

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Plasma Medicine in Dermatology: Basic Antimicrobial Efficacy Testing as Prerequisite to Clinical Plasma Therapy

Volume 2, Numéro 1-3, 2012, pp. 33-69
DOI: 10.1615/PlasmaMed.2014006217
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Georg Daeschlein
Department of Dermatology, University of Greifswald, Ferdinand Sauerbruchstrasse, 17475 Greifswald, Germany
Sebastian Scholz
Department of Dermatology, University of Greifswald, Ferdinand Sauerbruchstrasse, 17475 Greifswald, Germany
Steffen Emmert
Department of Dermatology, Venerology and Allergology, University Medical Center Gottingen, Georg-August-University, Gottingen, Germany
Sebastian von Podewils
Department of Dermatology of the University Medicine Greifswald
Hermann Haase
Department of Dermatology, University of Greifswald, Ferdinand Sauerbruchstrasse, 17475 Greifswald, Germany
Thomas von Woedtke
Leibniz Institute for Plasma Science and Technology e.V. (INP), Greifswald, Germany
Michael Junger
Department of Dermatology, University of Greifswald, Ferdinand Sauerbruchstrasse, 17475 Greifswald, Germany

RÉSUMÉ

Plasma medicine has become an emerging field in medical sciences since cold plasma has demonstrated significant antibacterial properties in vitro and in vivo. However, systematic antimicrobial plasma testing against bacteria, fungi, and parasites is still lacking. Chronic wounds, fungal skin and nail infections, and colonization with multidrug-resistant pathogens like Staphylococcus aureus (MRSA) often pose significant therapeutic and economical problems and new therapeutic concepts are strongly warranted. The challenge of worldwide increasing resistance problems including different pathogens like methicillin-resistant MRSA, vancomycin-resistant enterococci, and gram-negative species producing beta-lactam hydrolysing enzymes (extended spectrum β-lactamases) constitute the need for alternative antimicrobial treatments. Cold plasma therapy with a completely different mode of action compared to conventional antimicrobials may offer an alternative to conventional external antibiotic and antiseptic therapies. In order to estimate the possible role as physical antiseptic, basic susceptibility data from plasma are needed. To provide such data, the plasma susceptibility of representative skin and wound pathogens against low-temperature atmospheric pressure plasma jet (APPJ device) and dielectric barrier discharge plasma treatment was tested in vitro on agar. The same plasma sources were used to test clinical fungal isolates in vitro and isolates of the parasite demodex folliculorum ex vivo. Plasma treatment proved to be highly effective in eradicating all treated strains and species including Escherichia coli, Pseudomonas aeruginosa, Klebsiella group (K. pneumoniae ssp. pneumoniae, K. oxytoca), Staphylococcus aureus, hemolysing Lancefield Streptococci (group A and B), Proteus group (P. mirabilis, P. vulgaris), Acinetobacter spp, Stenotrophomonas spp., Enterococcus faecalis, Candida albicans, and Staphylococcus epidermidis. Plasma irradiation of Trichophyton rubrum, Trichophyton interdigitale, Microsporon canis, and the yeast Candida albicans was able to kill >90% of the organisms during 30 s in vitro with no isolate exhibiting resistance. The APPJ-plasma killed Demodex folliculorum after exposure time of 2 s. Our data suggest plasma as a possible new option in the treatment of microbial, fungal, and parasitic dermal infections.

MOTS CLÉS: atmospheric low-pressure plasma jet (APPJ), dielectric barrier discharge (DBD), antisepsis, dermatomycosis, Tinea pedis, fungi, plasma medicine, Trichophyton mentagrophytis var. interdigitale, Trichophyton, Microsporon, Candida spp., MRSA
CITÉ PAR

  1. Metelmann Hans-Robert, Nedrelow David S., Seebauer Christian, Schuster Matthias, von Woedtke Thomas, Weltmann Klaus-Dieter, Kindler Stefan, Metelmann Philine Henriette, Finkelstein Steven E., Von Hoff Daniel D., Podmelle Fred, Head and neck cancer treatment and physical plasma, Clinical Plasma Medicine, 3, 1, 2015. Crossref

  2. Hilker Lutz, von Woedtke Thomas, Weltmann Klaus Dieter, Wollert Hans-Georg, Cold atmospheric plasma: a new tool for the treatment of superficial driveline infections, European Journal of Cardio-Thoracic Surgery, 51, 1, 2017. Crossref

  3. Kramer Axel, Bekeschus Sander, Matthes Rutger, Bender Claudia, Stope Matthias B., Napp Matthias, Lademann Olaf, Lademann Jürgen, Weltmann Klaus-Dieter, Schauer Frieder, Cold Physical Plasmas in the Field of Hygiene-Relevance, Significance, and Future Applications, Plasma Processes and Polymers, 12, 12, 2015. Crossref

  4. von Woedtke Thomas, Schmidt Anke, Bekeschus Sander, Wende Kristian, Wissenschaftliche Grundlagen, Stand und Perspektiven der Plasmamedizin, in Plasmamedizin, 2016. Crossref

  5. Kramer Axel, Matthes Rutger, Bekeschus Sander, Bender Claudia, Napp Matthias, Lademann Olaf, Lademann Jürgen, Weltmann Klaus Dieter, Aktueller und perspektivischer Einsatz kalter Plasmen aus hygienischer Indikation, in Plasmamedizin, 2016. Crossref

  6. Classen Janine, Dengler Berrett, Klinger Christoph, Bettenay Sonya, Rickerts Volker, Mueller Ralf, Cutaneous alternariosis in an immunocompromised dog successfully treated with cold plasma and cessation of immunosuppressive medication, Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere, 45, 05, 2017. Crossref

  7. Limsopatham Kwankamol, Boonyawan Dheerawan, Umongno Chanchai, Sukontason Kabkaew L., Chaiwong Tarinee, Leksomboon Rattana, Sukontason Kom, Effect of cold argon plasma on eggs of the blow fly, Lucilia cuprina (Diptera: Calliphoridae), Acta Tropica, 176, 2017. Crossref

  8. Schmidt Anke, Bekeschus Sander, Wende Kristian, Vollmar Brigitte, von Woedtke Thomas, A cold plasma jet accelerates wound healing in a murine model of full-thickness skin wounds, Experimental Dermatology, 26, 2, 2017. Crossref

  9. Korotkiy V. N., The use of low-temperature atmospheric plasma in dermatology, Klinicheskaya dermatologiya i venerologiya, 16, 5, 2017. Crossref

  10. Dubuc Antoine, Monsarrat Paul, Virard François, Merbahi Nofel, Sarrette Jean-Philippe, Laurencin-Dalicieux Sara, Cousty Sarah, Use of cold-atmospheric plasma in oncology: a concise systematic review, Therapeutic Advances in Medical Oncology, 10, 2018. Crossref

  11. Reuter Stephan, von Woedtke Thomas, Weltmann Klaus-Dieter, The kINPen—a review on physics and chemistry of the atmospheric pressure plasma jet and its applications, Journal of Physics D: Applied Physics, 51, 23, 2018. Crossref

  12. von Woedtke Thomas, Schmidt Anke, Bekeschus Sander, Wende Kristian, Introduction to Plasma Medicine, in Comprehensive Clinical Plasma Medicine, 2018. Crossref

  13. Cheng Kuang-Yao, Lin Zhi-Hua, Cheng Yu-Pin, Chiu Hsien-Yi, Yeh Nai-Lun, Wu Tung-Kung, Wu Jong-Shinn, Wound Healing in Streptozotocin-Induced Diabetic Rats Using Atmospheric-Pressure Argon Plasma Jet, Scientific Reports, 8, 1, 2018. Crossref

  14. Breathnach Rory, McDonnell Kevin A., Chebbi Ahmed, Callanan John J., Dowling Denis P., Evaluation of the effectiveness of kINPen Med plasma jet and bioactive agent therapy in a rat model of wound healing, Biointerphases, 13, 5, 2018. Crossref

  15. Yan Xu, Zhang Chenyang, Ouyang Jiting, Meng Zhaozhong, Shi Zhongfang, Wang Yujiao, Chen Ye, Yuan Fang, Ostrikov Kostya (Ken), Cytoprotective effect of atmospheric pressure helium plasma on oxygen and glucose deprivation-induced cell death in H9C2 cardiac myoblasts and primary neonatal rat cardiomyocytes, Journal of Physics D: Applied Physics, 52, 13, 2019. Crossref

  16. Stancampiano Augusto, Gallingani Tommaso, Gherardi Matteo, Machala Zdenko, Maguire Paul, Colombo Vittorio, Pouvesle Jean-Michel, Robert Eric, Plasma and Aerosols: Challenges, Opportunities and Perspectives, Applied Sciences, 9, 18, 2019. Crossref

  17. Ambrico Paolo F., Šimek Milan, Rotolo Caterina, Morano Massimo, Minafra Angelantonio, Ambrico Marianna, Pollastro Stefania, Gerin Donato, Faretra Francesco, De Miccolis Angelini Rita M., Surface Dielectric Barrier Discharge plasma: a suitable measure against fungal plant pathogens, Scientific Reports, 10, 1, 2020. Crossref

  18. Madigan Cian D., O'Sullivan Denis, O'Neill Liam, Kavanagh Darren F., A comparison of two cold atmospheric helium plasma devices which utilise the same RF power generator, Clinical Plasma Medicine, 19-20, 2020. Crossref

  19. Tyczkowska-Sieroń Ewa, Kałużewski Tadeusz, Grabiec Magdalena, Kałużewski Bogdan, Tyczkowski Jacek, Genotypic and Phenotypic Changes in Candida albicans as a Result of Cold Plasma Treatment, International Journal of Molecular Sciences, 21, 21, 2020. Crossref

  20. Stryczewska Henryka Danuta, Boiko Oleksandr, Applications of Plasma Produced with Electrical Discharges in Gases for Agriculture and Biomedicine, Applied Sciences, 12, 9, 2022. Crossref

  21. Schmidt Anke, Bekeschus Sander, Jablonowski Helena, Barton Annemarie, Weltmann Klaus-Dieter, Wende Kristian, Role of Ambient Gas Composition on Cold Physical Plasma-Elicited Cell Signaling in Keratinocytes, Biophysical Journal, 112, 11, 2017. Crossref

  22. Fischer Maximilian, Schoon Janosch, Freund Eric, Miebach Lea, Weltmann Klaus-Dieter, Bekeschus Sander, Wassilew Georgi I., Biocompatible Gas Plasma Treatment Affects Secretion Profiles but Not Osteogenic Differentiation in Patient-Derived Mesenchymal Stromal Cells, International Journal of Molecular Sciences, 23, 4, 2022. Crossref

  23. Bekeschus Sander, Schmidt Anke, Weltmann Klaus-Dieter, von Woedtke Thomas, The plasma jet kINPen – A powerful tool for wound healing, Clinical Plasma Medicine, 4, 1, 2016. Crossref

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