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Critical Reviews™ in Eukaryotic Gene Expression

Publication de 6  numéros par an

ISSN Imprimer: 1045-4403

ISSN En ligne: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

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Parameters of LRP5 from a Structural and Molecular Perspective

Volume 15, Numéro 3, 2005, pp. 229-242
DOI: 10.1615/CritRevEukarGeneExpr.v15.i3.50
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RÉSUMÉ

LRP5, along with LRP6 and their Drosophila homolog, Arrow, constitute a novel subclass of the LDL receptor superfamily. The arrangement of structural motifs in these receptors is different from the other members of the superfamily, and only recently have we begun to understand the functional importance of human LRP5 (and LRP6). Whole genome positional cloning studies have identified a number of mutations in LRP5 that underlie inherited human diseases/phenotypes, particularly those involving the skeleton and the eye. A number of studies have illustrated the importance of Lrp5/6/Arrow as a co-receptor with Frizzled for the Wnt proteins and their critical role in the regulation of the Wnt/β-catenin signaling pathway. The cataloging of these human mutations, in combination with engineered mutations in mice and other studies involving gene/protein modifications, has led to a better understanding of the function of the various domains in LRP5/6. In this review, we discuss a number of studies that have revealed a wide variety of protein-protein interactions that occur with the various structural motifs in the Lrp5 protein. Ultimately, these interactions regulate the activity of the Wnt/β-catenin signaling pathway and the role it plays in processes such as bone mass accrual and vision.

CITÉ PAR
  1. Rajamannan Nalini M., The role of Lrp5/6 in cardiac valve disease: LDL-density-pressure theory, Journal of Cellular Biochemistry, 112, 9, 2011. Crossref

  2. Johnson Mark L., Wnt Signaling and Bone, in Principles of Bone Biology, 2008. Crossref

  3. Johnson Mark L, Kamel Mohamed A, The Wnt signaling pathway and bone metabolism, Current Opinion in Rheumatology, 19, 4, 2007. Crossref

  4. Johnson Mark L., Rajamannan Nalini, Diseases of Wnt signaling, Reviews in Endocrine and Metabolic Disorders, 7, 1-2, 2007. Crossref

  5. Zhong Zhendong, Ethen Nicole J., Williams Bart O., WNT signaling in bone development and homeostasis, Wiley Interdisciplinary Reviews: Developmental Biology, 3, 6, 2014. Crossref

  6. Doubleday Alison F., Kaestle Frederika A., Cox Laura A., Birnbaum Shifra, Mahaney Michael C., Havill Lorena M., LRP5sequence and polymorphisms in the baboon, Journal of Medical Primatology, 38, 2, 2009. Crossref

  7. Rajamannan Nalini M, Myxomatous mitral valve disease bench to bedside: LDL-density-pressure regulates Lrp5, Expert Review of Cardiovascular Therapy, 12, 3, 2014. Crossref

  8. Johnson Mark L., Recker Robert R., Wnt Signaling in Bone, in Fundamentals of Osteoporosis, 2010. Crossref

  9. Johnson Mark L, LRP5 and bone mass regulation: Where are we now?, BoneKEy Reports, 1, 2012. Crossref

  10. JOHNSON MARK L., RECKER ROBERT R., Wnt Signaling in Bone, in Osteoporosis, 2008. Crossref

  11. Rudnicki Michael A., Williams Bart O., Wnt signaling in bone and muscle, Bone, 80, 2015. Crossref

  12. Henríquez J. P., Salinas P. C., Dual roles for Wnt signalling during the formation of the vertebrate neuromuscular junction, Acta Physiologica, 204, 1, 2012. Crossref

  13. Rajamannan Nalini M., The role of Lrp5/6 in cardiac valve disease: Experimental hypercholesterolemia in the ApoE−/−/Lrp5−/− mice, Journal of Cellular Biochemistry, 112, 10, 2011. Crossref

  14. Bhat Bheem M., Allen Kristina M., Liu Wei, Graham James, Morales Art, Anisowicz Anthony, Lam Ho-Sun, McCauley Catherine, Coleburn Valerie, Cain Michael, Fortier Eric, Bhat Ramesh A., Bex Frederick J., Yaworsky Paul J., Structure-based mutation analysis shows the importance of LRP5 β-propeller 1 in modulating Dkk1-mediated inhibition of Wnt signaling, Gene, 391, 1-2, 2007. Crossref

  15. Cheng Zhihong, Biechele Travis, Wei Zhiyi, Morrone Seamus, Moon Randall T, Wang Liguo, Xu Wenqing, Crystal structures of the extracellular domain of LRP6 and its complex with DKK1, Nature Structural & Molecular Biology, 18, 11, 2011. Crossref

  16. Rajamannan Nalini M., Osteocardiology: The Atherosclerotic Bone Paradox, in Osteocardiology, 2018. Crossref

  17. Majidinia Maryam, Aghazadeh Javad, Jahanban‐Esfahlani Rana, Yousefi Bahman, The roles of Wnt/β‐catenin pathway in tissue development and regenerative medicine, Journal of Cellular Physiology, 233, 8, 2018. Crossref

  18. Rajamannan Nalini Marie, LDL-Density-Theory: Clinical Trial Design for Aortic Valve Disease, in Cardiac Valvular Medicine, 2013. Crossref

  19. Williams Bart O., Johnson Mark L., Wnt signaling and bone cell activity, in Principles of Bone Biology, 2020. Crossref

  20. Rajamannan Nalini M., Experimental Hypercholesterolemia in Genetic ApoE−/−/Lrp5−/− Mice: Proof of Principle, in Molecular Biology of Valvular Heart Disease, 2014. Crossref

  21. Holdsworth Gill, Slocombe Patrick, Doyle Carl, Sweeney Bernadette, Veverka Vaclav, Le Riche Kelly, Franklin Richard J., Compson Joanne, Brookings Daniel, Turner James, Kennedy Jeffery, Garlish Rachael, Shi Jiye, Newnham Laura, McMillan David, Muzylak Mariusz, Carr Mark D., Henry Alistair J., Ceska Thomas, Robinson Martyn K., Characterization of the Interaction of Sclerostin with the Low Density Lipoprotein Receptor-related Protein (LRP) Family of Wnt Co-receptors, Journal of Biological Chemistry, 287, 32, 2012. Crossref

  22. Haÿ Eric, Laplantine Emmanuel, Geoffroy Valérie, Frain Monique, Kohler Thomas, Müller Ralph, Marie Pierre J., N-Cadherin Interacts with Axin and LRP5 To Negatively Regulate Wnt/β-Catenin Signaling, Osteoblast Function, and Bone Formation, Molecular and Cellular Biology, 29, 4, 2009. Crossref

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