Publication de 6 numéros par an
ISSN Imprimer: 1045-4403
ISSN En ligne: 2162-6502
Indexed in
ABCB1 Polymorphisms and Childhood Acute Lymphoblastic Leukemia Risk: A Meta-Analysis
RÉSUMÉ
The association between ATP-binding cassette subfamily B member 1 (ABCB1) C3435T and C1236T polymorphisms and the risk for childhood acute lymphoblastic leukemia (ALL) is inconclusive. We conducted a meta-analysis of all published studies to determine the association of ABCB1 C3435T and C1236T polymorphisms and pediatric ALL risk. A systematic retrieval of relevant publications from the PubMed and Web of Science databases was performed. Data were calculated and statistical analysis was performed using STATA version 12.0 software. Metaanalysis results showed no significant association between C3435T polymorphism and pediatric ALL risk (TT vs. CC: odds ratio [OR] = 1.20, 95% confidence interval [CI] = 0.95–1.52; CT vs. CC: OR = 1.00, 95% CI = 0.82–1.23; the dominant model: OR = 1.07, 95% CI = 0.89–1.29; the recessive model: OR = 1.17, 95% CI = 0.84–1.62). Similarly, there was no association found for the C1236T polymorphism (TT vs. CC: OR = 1.18, 95% CI= 0.82–1.70; CT vs. CC: OR = 1.08, 95% CI = 0.80–1.45; the dominant model: OR = 1.10, 95% CI= 0.83–1.46; the recessive model: OR = 0.98, 95% CI = 0.61–1.58). Similar results were observed in the subgroup analyses on ethnicity and Hardy–Weinberg equilibrium. The present meta-analysis found no evidence for ABCB1 C3435T and C1236T polymorphisms as risk factors for pediatric ALL.
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Li Yang, He Li-Ru, Gao Ying, Zhou Ning-Ning, Liu Yurong, Zhou Xin-Ke, Liu Ji-Fang, Guan Xin-Yuan, Ma Ning-Fang, Xie Dan, CHD1L contributes to cisplatin resistance by upregulating the ABCB1–NF-κB axis in human non-small-cell lung cancer, Cell Death & Disease, 10, 2, 2019. Crossref
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Liu Wei, Li Yan, Zhao Zhenhui, Li Xun, Clinical relevance of multi-drug resistance gene C3435T polymorphism in diffuse large B-cell lymphoma in Xinjiang, Medicine, 99, 35, 2020. Crossref