Abonnement à la biblothèque: Guest
International Journal of Physiology and Pathophysiology

Publication de 4  numéros par an

ISSN Imprimer: 2155-014X

ISSN En ligne: 2155-0158

SJR: 0.116

Nerve Growth Factor-Induced Changes in Adrenergic Modulation of Calcium Currents in Trigeminal Ganglion Neurons

Volume 9, Numéro 2, 2018, pp. 153-160
DOI: 10.1615/IntJPhysPathophys.v9.i2.70
Get accessGet access

RÉSUMÉ

We investigate the influence of noradrenaline on voltage-dependent calcium currents (VDCCs) in trigeminal ganglion neurons (TGN) cultivated with and without nerve growth factors (NGF). Application of noradrenaline (100 µmol/L) did not evoke changes in low-threshold VGCCs, but suppressed high-threshold VGCCs. In particular, it caused a decrease in the amplitude of high-threshold VDCCs in presence of NGF and without it by (30 ± 5) and 13 ± 8%, respectively. An inhibition of the fast component of high-threshold VDCCs was observed in majority of TGN which cultivated with NGF. The above-mentioned changes in kinetics occurred in 11 of 13 neurons in the culture with NGF, and only in 3 of 15 neurons in NGF-free culture. The results of experiments have shown the interrelations between the adrenergic modulation of VDCCs and level of NGF. At that, only high-threshold VDCCs are involved in adrenergic modulation of electrical activity. Thus, an increase in the NGF level not only triggers the mechanisms of sprouting of sympathetic fibers, but also leads to an increase in adrenergic effects on sensory signal transmission.

801 Vues d'articles 7 Téléchargements d'articles Métrique
801 VUES 7 TÉLÉCHARGEMENTS Google
Scholar
CITATIONS

Articles avec un contenu similaire:

Endothelium-Derived Hyperpolarizing Factor as a Reserve Defense Mechanism of the Vascular Control under Ionizing Radiation Impact International Journal of Physiology and Pathophysiology, Vol.3, 2012, issue 2
Olga V. Kislova, Anatoly I. Soloviev, Irina V. Ivanova
Changes in Calcium-Dependent Potassium Conductance of Isolated Smooth Muscle Cells of the Rat Bladder in Experimental Diabetes International Journal of Physiology and Pathophysiology, Vol.3, 2012, issue 1
Oksana M. Paduraru, Dmytro A. Kryshtal, Oleg Yu. Kit, Oleksiy I. Boldyriev, Yaroslav M. Shuba, Volodymyr V. Rekalov
Immunomodulating Effects Exerted by Glucans Extracted from the King Oyster Culinary-Medicinal Mushroom Pleurotus eryngii (Agaricomycetes) Grown in Substrates Containing Various Concentrations of Olive Mill Waste International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 8
Yitzhak Hadar, Vaclav Vetvicka, Nirit Ezov, Betty Schwartz, Ofer Gover, Ofer Danay, Hilla Hayby
Contribution of Eicosanoids to the Mechanisms of Contractile Responses of the Portal Vein to Adrenaline and Noradrenaline International Journal of Physiology and Pathophysiology, Vol.5, 2014, issue 4
Sergiy S. Kostenko, Petro I. Yanchuk, Olena O. Vingradova, Oleg M. Pasichnichenko
Vasodilatation Effects of Fluorine- Containing KATP Channels Opener of Flocalin International Journal of Physiology and Pathophysiology, Vol.2, 2011, issue 1
Ruslan B. Strutynskyi

Dernier numéro

Systemic Toxic Dental Sealant-Induced Effect on Nervous Tissue in vitro O. A. Znachkova, Irina V. Lushnikova, Galina G. Skibo, M. Y. Antonenko, Nana V. Voitenko Impact of Various Polyphenols on Disturbance of Cholesterol Metabolism under Insulin Resistance V. P. Fylymonenko, A. L. Zagayko Target Correction of Mitochondrial Dysfunction in Parkinson's Disease by Capicor Iryna M. Mankovska, Kateryna V. Rosova, Olga O. Gonchar, Valentina I. Nosar, Larisa. V. Bratus, Tetyana I. Drevitska, Ivan D. Glazyrin, Nina V. Karasevich, Iryna M. Karaban Changes in Ongoing Activity and Electrophysiological Characteristics of the Rat Retinal Ganglion Cells in Diabetes Mellitus N. Ya. Martyniuk, V. Yu. Maslov, Helen E. Purnyn, Svetlana A. Fedulova, Nikolai S. Veselovsky Sex Characteristics of Hydrogen Sulfide Effect on Ischemia-Reperfusion in Rat Myocardium Andrii V. Melnyk, Nataliia V. Zaichko, Oleksii A. Khodakovskyi, Olga V. Khodakivska Cardiohemodynamic Changes in Focal Cerebral Ischemia Roman R. Sharipov, Nataliya A. Dorofeyeva, Vadim F. Sagach Cerebral Hemodynamics and Electroencephalographic Pattern in Patients with Symptomatic Epilepsy at Combined Treatment with Transcranial Direct Current Stimulation Kateryna V. Yatsenko Physiological Endurance of Skeletal Muscle Increases under C60 Fullerene Application before Physical Load Tetyana Yu. Matvienko, Danylo Zavodovskiy, Iryna V. Mishchenko, Kateryna I. Bogutska, Yuriy I. Prylutskyy, Sofia Paradizova, Larisa Bezuh, Uwe Ritter, Peter Scharff Possible Mechanisms Underlying Association between Thyroiditis and Thyroid Papillary Carcinoma Tamara M. Myshunina, Mykola D. Tronko Index, Volume 9, 2018
Portail numérique Bibliothèque numérique eBooks Revues Références et comptes rendus Collections Prix et politiques d'abonnement Begell House Contactez-nous Language English 中文 Русский Português German French Spain