Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
Indexed in
Antiatherogenic Potential of Extracts from the Gray Oyster Medicinal Mushroom, Pleurotus pulmonarius (Agaricomycetes), In Vitro
RÉSUMÉ
This study evaluates the in vitro inhibition of angiotensin-converting enzyme (ACE) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA) by Pleurotus pulmonarius extracts. The protective effect on the endothelial membrane against oxidative stress through the protection of nitric oxide bioavailability, as well as inhibition of endocan expression, was evaluated using human aortic endothelial cells (HAECs). Crude cold aqueous extract exhibited the most potent inhibitory activities against ACE and HMG-CoA reductase, with 61.79% and 44.30% inhibition, respectively. It also protected the bioavailability of NO released by HAECs, with 84.88% cell viability. The crude hot water extract was the most potent in inhibiting endocan expression, with 18.61% inhibition.
-
Badalyan Susanna M., Barkhudaryan Anush, Rapior Sylvie, Recent Progress in Research on the Pharmacological Potential of Mushrooms and Prospects for Their Clinical Application, in Medicinal Mushrooms, 2019. Crossref
-
Mahfuz S.U., Long S.F., Piao X.S., Role of medicinal mushroom on growth performance and physiological responses in broiler chicken, World's Poultry Science Journal, 76, 1, 2020. Crossref
-
Amirullah Nur Amalina, Zainal Abidin Nurhayati, Abdullah Noorlidah, Manickam Sivakumar, Application of ultrasound towards improving the composition of phenolic compounds and enhancing in vitro bioactivities of Pleurotus pulmonarius (Fr.) Quél extracts, Biocatalysis and Agricultural Biotechnology, 31, 2021. Crossref
-
Amirullah Nur Amalina, Zainal Abidin Nurhayati, Abdullah Noorlidah, Manickam Sivakumar, The ultrasound extract of Pleurotus pulmonarius (Fr.) Quél alleviates metabolic syndromes in hyperlipidaemic Wistar-Kyoto rats fed with a high-fat diet, Biocatalysis and Agricultural Biotechnology, 34, 2021. Crossref