Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
Indexed in
Effect of Hispolon from Phellinus lonicerinus (Agaricomycetes) on Estrogen Receptors, Aromatase, and Cyclooxygenase II in MCF-7 Breast Cancer Cells
RÉSUMÉ
Phytoestrogen has previously been proposed as an alternative to hormone replacement therapy. Hispolon has been found to have phytoestrogenic properties. However, the possible effects of hispolon on estrogen receptors and other related molecules remain to be determined. This study was performed mainly to confirm the estrogenic function of hispolon as it relates to estrogen receptors, aromatase, and cyclooxygenase 2 (COX-2). Hispolon was shown to increase the serum 17β-estradiol in vivo. Immunohistochemical staining methods showed that hispolon exhibited a biphasic effect on ERα/β and aromatase expression in MCF-7 cells. Hispolon could also significantly inhibit aromatase activity, assessed using the enzyme-linked immunosorbent assay. Western blotting showed that COX-2 and aromatase could be inhibited by hispolon. These results further prove the phytoestrogenic features of hispolon and explore some pharmacological mechanisms that suggest that hispolon could be useful in the treatment of breast cancers or other gynecologic diseases.
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Sarfraz Ayesha, Rasul Azhar, Sarfraz Iqra, Shah Muhammad Ajmal, Hussain Ghulam, Shafiq Nusrat, Masood Muqaddas, Adem Şevki, Sarker Satyajit D., Li Xiaomeng, Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways, Environmental Research, 190, 2020. Crossref
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Islam Muhammad T., Ali Eunus S., Khan Ishaq N., Shaw Subrata, Uddin Shaikh Jamal, Rouf Razina, Dev Shrabanti, Saravi Seyed S.S., Das Niranjan, Tripathi Swati, Yele Santosh U., Das Asish K., Shilpi Jamil A., Mishra Siddhartha K., Mubarak Mohammad S., Anticancer Perspectives on the Fungal-Derived Polyphenolic Hispolon, Anti-Cancer Agents in Medicinal Chemistry, 20, 14, 2020. Crossref
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Zhao Yanxia, Zheng Weifa, Deciphering the antitumoral potential of the bioactive metabolites from medicinal mushroom Inonotus obliquus, Journal of Ethnopharmacology, 265, 2021. Crossref
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Das Somenath, Prakash Bhanu, Edible mushrooms: Nutritional composition and medicinal benefits for improvement in quality life, in Research and Technological Advances in Food Science, 2022. Crossref