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International Journal of Medicinal Mushrooms

Publication de 12  numéros par an

ISSN Imprimer: 1521-9437

ISSN En ligne: 1940-4344

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Antiproliferative, Immunostimulatory, and Anti-Inflammatory Activities of Extracts Derived from Mushrooms Collected in Haida Gwaii, British Columbia (Canada)

Volume 21, Numéro 7, 2019, pp. 629-643
DOI: 10.1615/IntJMedMushrooms.2019031193
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RÉSUMÉ

Wild mushrooms, while largely explored for their ecological significance, have not been systematically studied for their medicinal properties. This is the first report of biological activities of mushrooms from Haida Gwaii, British Columbia, Canada. The 17 mushroom species in this study were collected from multiple locations on Haida Gwaii and were screened for antiproliferative, immunostimulatory, and anti-inflammatory activities. Prior to screening, mushrooms were genetically identified and then sequentially fractionated into four crude extracts using 80% ethanol, 50% methanol, water, and 5% sodium hydroxide. We report here the strong antiproliferative and antiinflammatory activities of Amanita augusta, Phellodon atratus, Guepinia helvelloides, Chroogomphus tomentosus, Laetiporus conifericola, and Inocybe sp. In addition, A. augusta, G. helvelloides, and Inocybe sp. showed potent immunostimulatory activity. Two other species (Ganoderma tsugae and Pleurotus ostreatus) displayed strong immunostimulatory activity consistent with previous reports by others, suggesting that similar constituents are present in the same species from Haida Gwaii. For nine species (Russula paludosa, Hygrophoropsis aurantiaca, Tricholomopsis rutilans, Tyromyces chioneus, Hydnum repandum, Hypholoma fasciculare, Clavulina cinerea, P. ostreatus and Ramaria cystidiophora), we describe antiproliferative, immunostimulatory, and/or anti-inflammatory activities that have never been reported before. The new findings serve as a platform for future investigations into the potentially novel bioactive constituents of these mushrooms, as well as an incentive to further study a wider array of wild mushrooms for medicinal properties.

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CITÉ PAR
  1. Javed Sumreen, Li Wai Ming, Zeb Mehreen, Yaqoob Almas, Tackaberry Linda E., Massicotte Hugues B., Egger Keith N., Cheung Peter C.K., Payne Geoffrey W., Lee Chow H., Anti-Inflammatory Activity of the Wild Mushroom, Echinodontium tinctorium, in RAW264.7 Macrophage Cells and Mouse Microcirculation, Molecules, 24, 19, 2019. Crossref

  2. Yaqoob Almas, Li Wai Ming, Liu Victor, Wang Chuyi, Mackedenski Sebastian, Tackaberry Linda E., Massicotte Hugues B., Egger Keith N., Reimer Kerry, Lee Chow H., Amin A R M Ruhul, Grifolin, neogrifolin and confluentin from the terricolous polypore Albatrellus flettii suppress KRAS expression in human colon cancer cells, PLOS ONE, 15, 5, 2020. Crossref

  3. Antonceva Ekaterina, Shamtsyan Mark, Shamtsyan M., Ignateva S., Fortification of dairy product Narine with polysaccharides from oyster mushroom, E3S Web of Conferences, 215, 2020. Crossref

  4. Tan Maoling, Zhao Gang, Characterization and phylogenetic analysis of the complete mitochondrial genome of Clavulina sp. (Cantharellales: Clavulinaceae), Mitochondrial DNA Part B, 5, 3, 2020. Crossref

  5. Gryzenhout Marieka, Ghosh Soumya, Tchotet Tchoumi James Michel, Vermeulen Marcele, Kinge Tonjock Rosemary, Ganoderma: Diversity, Ecological Significances, and Potential Applications in Industry and Allied Sectors, in Industrially Important Fungi for Sustainable Development, 2021. Crossref

  6. Zeb Mehreen, Lee Chow H., Medicinal Properties and Bioactive Compounds from Wild Mushrooms Native to North America, Molecules, 26, 2, 2021. Crossref

  7. He Xiao, Zhao Chang-Lin, Diversity of Wood-Decaying Fungi in Wuliangshan Area, Yunnan Province, P.R. China, Diversity, 14, 2, 2022. Crossref

  8. Stastny Jan, Marsik Petr, Tauchen Jan, Bozik Matej, Mascellani Anna, Havlik Jaroslav, Landa Premysl, Jablonsky Ivan, Treml Jakub, Herczogova Petra, Bleha Roman, Synytsya Andriy, Kloucek Pavel, Antioxidant and Anti-Inflammatory Activity of Five Medicinal Mushrooms of the Genus Pleurotus, Antioxidants, 11, 8, 2022. Crossref

  9. Lee Hooi Xian, Li Wai Ming, Khatra Jatinder, Xia Zhicheng, Sannikov Oleg, Ling Yun, Zhu Haoxuan, Lee Chow H., Antiproliferative Fatty Acids Isolated from the Polypore Fungus Onnia tomentosa, Journal of Fungi, 8, 11, 2022. Crossref

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