Publication de 12 numéros par an
ISSN Imprimer: 1521-9437
ISSN En ligne: 1940-4344
Indexed in
The Extraction and Development of Antitumor-Active Polysaccharides from Medicinal Mushrooms in Japan (Review)
RÉSUMÉ
It has been known for many years that most mushrooms with known effects against cancer belong to the family Polyporaceae s.l. (Agaricales s.l.). However, the components responsible for such action have not been clearly defined. In Japan, in 1968, a hot water extract from some edible mushrooms belonging to the family Polyporaceae s.l., showed a marked host-mediated antitumor activity. Since then, numerous researchers have isolated active polysaccharides and have identified them to be (1→3)-β-D-glucopyranans with a (1→6)-β-D-glucosyl branch containing protein. Several antitumor polysaccharides, some hetero-β-glucans and their protein complexes, such as xyloglucans and acidic β-glucan containing uronic acid, are insoluble in water. They were, however, isolated from the extracts using large amounts of dilute alkali with Japanese (8 species) and Chinese (5 species) mushrooms. Several trials have been made to enhance activity by chemical modification, such as polyalcohols formed by a mild Smith degradation and the products formed by BH4-reduction after 104-oxidation. Mushroom polysaccharides are considered to be biological response modifiers (BRM), or immunopotentiators, because of their action mechanism. In Japan, three different polysaccharide antitumor agents have been developed from the fruit body, mycelium, and cultured medium, of three mushroom species.
-
ZHANG Pingyi, CHEUNG Peter C. K., Evaluation of SulfatedLentinus Edodesα-(1→3)-D-Glucan as a Potential Antitumor Agent, Bioscience, Biotechnology, and Biochemistry, 66, 5, 2002. Crossref
-
TAKATA Ryoji, YAMAMOTO Reiko, YANAI Takaaki, KONNO Tomonori, OKUBO Toshiyuki, Immunostimulatory Effects of a Polysaccharide-Rich Substance with Antitumor Activity Isolated from Black Currant (Ribes nigrumL.), Bioscience, Biotechnology, and Biochemistry, 69, 11, 2005. Crossref
-
Hybelbauerová Simona, Sejbal Jan, Dračínský Martin, Hahnová Alice, Koutek Bohumír, Chemical Constituents ofStereum subtomentosum and Two Other Birch-Associated Basidiomycetes: An Interspecies Comparative Study, Chemistry & Biodiversity, 5, 5, 2008. Crossref
-
Evsenko M. S., Shashkov A. S., Avtonomova A. V., Krasnopolskaya L. M., Usov A. I., Polysaccharides of basidiomycetes. Alkali-soluble polysaccharides from the mycelium of white rot fungus Ganoderma lucidum (Curt.: Fr.) P. Karst, Biochemistry (Moscow), 74, 5, 2009. Crossref
-
Spěváček Jiří, Brus Jiří, Solid-State NMR Studies of Polysaccharide Systems, Macromolecular Symposia, 265, 1, 2008. Crossref
-
El-Enshasy H., Daba A., El-Demella M., Ibrahim A., El Sayed S., El-Badry I., Bioprocess Development for Large Scale Production of Anticancer Exo-Polysaccharide by Pleurotus ostreatus in Submerged Culture, Journal of Applied Sciences, 10, 21, 2010. Crossref
-
Kim Sang Ho, Jakhar Rekha, Kang Sun Chul, Apoptotic properties of polysaccharide isolated from fruiting bodies of medicinal mushroom Fomes fomentarius in human lung carcinoma cell line, Saudi Journal of Biological Sciences, 22, 4, 2015. Crossref
-
Kozhemyakina N. V., Ananyeva E. P., Gurina S. V., Galynkin V. A., Conditions of cultivation, composition, and biological activity of mycelium of Flammulina velutipes (Fr.) P. Karst, Applied Biochemistry and Microbiology, 46, 5, 2010. Crossref
-
Yadav Lal Dhar S., Yadav Beerendra S., Rai Vijai K., Multicomponent reactions in chiral ionic liquids: A stereocontrolled route to mercaptopyranothiazoles, Journal of Heterocyclic Chemistry, 45, 5, 2008. Crossref
-
WANG PING, SHI JUNLING, ZHU YI, YANG BAOWEI, DU SHUANGKUI, OPTIMAL CONDITIONS FOR THE GROWTH AND POLYSACCHARIDE PRODUCTION BYHYPSIZIGUS MARMOREUSIN SUBMERGED CULTURE, Journal of Food Processing and Preservation, 33, 4, 2009. Crossref
-
Xiang Yuling, Xu Xiangqun, Li Juan, Chemical properties and antioxidant activity of exopolysaccharides fractions from mycelial culture of Inonotus obliquus in a ground corn stover medium, Food Chemistry, 134, 4, 2012. Crossref
-
Lima L. F. O., Habu S., Gern J. C., Nascimento B. M., Parada Jose-Luis, Noseda M. D., Gonçalves A. G., Nisha V. R., Pandey Ashok, Soccol Vanete Thomaz, Soccol Carlos R., Production and Characterization of the Exopolysaccharides Produced by Agaricus brasiliensis in Submerged Fermentation, Applied Biochemistry and Biotechnology, 151, 2-3, 2008. Crossref
-
Karaman Maja, Mimica-Dukic Neda, Matavuly Milan, Lignicolous fungi from northern Serbia as natural sources of antioxidants, Open Life Sciences, 4, 3, 2009. Crossref
-
Lung Ming Yeou, Tsai Jie Chung, Huang Ping Chang, Antioxidant Properties of Edible BasidiomyceteâPhellinus igniariusâin Submerged Cultures, Journal of Food Science, 75, 1, 2010. Crossref
-
Wasser Solomon P., Current findings, future trends, and unsolved problems in studies of medicinal mushrooms, Applied Microbiology and Biotechnology, 89, 5, 2011. Crossref
-
Ferreira Isabel C.F.R., Heleno Sandrina A., Reis Filipa S., Stojkovic Dejan, Queiroz Maria João R.P., Vasconcelos M. Helena, Sokovic Marina, Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities, Phytochemistry, 114, 2015. Crossref
-
Xu Ming-Lu, Choi Jae-Young, Jeong Byeong-Seon, Li Gao, Lee Kap-Rang, Lee Chong-Soon, Woo Mi-Hee, Lee Eung Seok, Jahng Yurngdong, Chang Hyeun-Wook, Lee Seung-Ho, Son Jong-Keun, Cytotoxic constituents isolated from the fruit bodies ofHypsizigus marmoreus, Archives of Pharmacal Research, 30, 1, 2007. Crossref
-
Vinogradov Evgeny, Petersen Bent O, Duus Jens Ø, Wasser Solomon, The structure of the glucuronoxylomannan produced by culinary-medicinal yellow brain mushroom (Tremella mesenterica Ritz.:Fr., Heterobasidiomycetes) grown as one cell biomass in submerged culture, Carbohydrate Research, 339, 8, 2004. Crossref
-
Öztürk Mehmet, Tel-Çayan Gülsen, Muhammad Akhtar, Terzioğlu Pınar, Duru Mehmet Emin, , 45, 2015. Crossref
-
Politi Matteo, Groves Patrick, Chávez M. Isabel, Cañada F. Javier, Jiménez-Barbero Jesús, Useful applications of DOSY experiments for the study of mushroom polysaccharides, Carbohydrate Research, 341, 1, 2006. Crossref
-
Askin Ruhan, Sasaki Mitsuru, Goto Motonobu, Recovery of water-soluble compounds from Ganoderma lucidum by hydrothermal treatment, Food and Bioproducts Processing, 88, 2-3, 2010. Crossref
-
Moradali Mohammad-Fata, Mostafavi Hossein, Ghods Shirin, Hedjaroude Ghorban-Ali, Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi), International Immunopharmacology, 7, 6, 2007. Crossref
-
Tao Yongzhen, Zhang Lina, Cheung Peter C.K., Physicochemical properties and antitumor activities of water-soluble native and sulfated hyperbranched mushroom polysaccharides, Carbohydrate Research, 341, 13, 2006. Crossref
-
Shu Chin-Hang, Lung Ming-Yeou, Effect of culture pH on the antioxidant properties of Antrodia camphorata in submerged culture, Journal of the Chinese Institute of Chemical Engineers, 39, 1, 2008. Crossref
-
Wang Jianguo, Wang Yutang, Liu Xuebo, Yuan Yahong, Yue Tianli, Free radical scavenging and immunomodulatory activities of Ganoderma lucidum polysaccharides derivatives, Carbohydrate Polymers, 91, 1, 2013. Crossref
-
Wang Zhen-Bin, Pei Juan-Juan, Ma Hai-Le, Cai Pan-Fu, Yan Jing-Kun, Effect of extraction media on preliminary characterizations and antioxidant activities of Phellinus linteus polysaccharides, Carbohydrate Polymers, 109, 2014. Crossref
-
Huang Xiaojun, Nie Shaoping, The structure of mushroom polysaccharides and their beneficial role in health, Food & Function, 6, 10, 2015. Crossref
-
Mohamad Shaiful Azuar, Awang Mat Rasol, Ibrahim Rusli, Keong Choong Yew, Hamzah Mohd Yusof, Abdul Rashid Rosnani, Hussein Sobri, Abdul Rahim Khairuddin, Daud Fauzi, Hamid Aidil Abdul, Wan Yusoff Wan Mohtar, Production of Endopolysaccharides from Malaysia’s Local Mushrooms in Air-Lift Bioreactor, Advances in Bioscience and Biotechnology, 06, 07, 2015. Crossref
-
Lee Wi Young, Park Youngki, Ahn Jin Kwon, Ka Kang Hyeon, Park So Young, Factors influencing the production of endopolysaccharide and exopolysaccharide from Ganoderma applanatum, Enzyme and Microbial Technology, 40, 2, 2007. Crossref
-
Chang Jong-Sun, Son Jong-Keun, Li Gao, Oh Eun-Jung, Kim Ji-Young, Park Sun-Hee, Bae Joon-Tae, Kim Hyun-Jeong, Lee In-Seon, Kim Ok-Mi, Kozukue Nobuyuki, Han Jae-Sook, Hirose Masao, Lee Kap-Rang, Inhibition of cell cycle progression on HepG2 cells by hypsiziprenol A9, isolated from Hypsizigus marmoreus, Cancer Letters, 212, 1, 2004. Crossref
-
Goel Atul, Verma Deepti, Singh Fateh Veer, A vicarious synthesis of unsymmetrical meta- and para- terphenyls from 2H-pyran-2-ones, Tetrahedron Letters, 46, 49, 2005. Crossref
-
Shamtsyan Mark, Konusova Valentina, Maksimova Yulia, Goloshchev Alexander, Panchenko Andrey, Simbirtsev Andrey, Petrishchev Nikolay, Denisova Nina, Immunomodulating and anti-tumor action of extracts of several mushrooms, Journal of Biotechnology, 113, 1-3, 2004. Crossref
-
Li Hua, See Hye-Jung, Moon BoKyung, Yoo Young-Bok, Lee Chan, Neuritogenic activity of hot water extract from Hericium erinaceus, Journal of Mushroom, 11, 3, 2013. Crossref
-
Wang Jianguo, Zhang Lina, Structure and chain conformation of five water-soluble derivatives of a β-d-glucan isolated from Ganoderma lucidum, Carbohydrate Research, 344, 1, 2009. Crossref
-
Dong Qun, Wang Ying, Shi Lei, Yao Jian, Li Jie, Ma Fangli, Ding Kan, A novel water-soluble β-d-glucan isolated from the spores of Ganoderma lucidum, Carbohydrate Research, 353, 2012. Crossref
-
Sarangi Itisam, Ghosh Dipanjan, Bhutia Sujit Kumar, Mallick Sanjaya Kumar, Maiti Tapas K., Anti-tumor and immunomodulating effects of Pleurotus ostreatus mycelia-derived proteoglycans, International Immunopharmacology, 6, 8, 2006. Crossref
-
Zhang Lina, Li Xuelian, Xu Xiaojuan, Zeng Fanbo, Correlation between antitumor activity, molecular weight, and conformation of lentinan, Carbohydrate Research, 340, 8, 2005. Crossref
-
Nagatsu Akito, Itoh Shizue, Tanaka Rie, Kato Setsuko, Haruna Mitsumasa, Kishimoto Keiichi, Hirayama Hideki, Goda Yukihiro, Mizukami Hajime, Ogihara Yukio, Identification of novel substituted fused aromatic compounds, meshimakobnol A and B, from natural Phellinus linteus fruit body, Tetrahedron Letters, 45, 30, 2004. Crossref
-
Omarsdottir Sesselja, Freysdottir Jona, Olafsdottir Elin Soffia, Immunomodulating polysaccharides from the lichen Thamnolia vermicularis var. subuliformis, Phytomedicine, 14, 2-3, 2007. Crossref
-
Park Eun-Jin, Lee Jun-Soo, Choi Won-Seok, Anti-cariogenic Activities of Mushroom Extracted with Various Solvent Systems, Korean Journal of Food Science and Technology, 43, 6, 2011. Crossref
-
Jin Yong, Zhang Lina, Zhang Mei, Chen Li, Keung Cheung Peter Chi, Oi V.E.C, Lin Yulu, Antitumor activities of heteropolysaccharides of Poria cocos mycelia from different strains and culture media, Carbohydrate Research, 338, 14, 2003. Crossref
-
Singh Fateh V., Dixit Manish, Chaurasia Sumit, Raghunandan Resmi, Maulik Prakas R., Goel Atul, A substituent-controlled general approach to access arylated pyran-2-ones and pyrano[3,4-c]pyran-1,8-diones, Tetrahedron Letters, 48, 51, 2007. Crossref
-
Baker John R., Kim Jeong-Su, Park Soon-Young, Composition and proposed structure of a water-soluble glycan from the Keumsa Sangwhang Mushroom (Phellinus linteus), Fitoterapia, 79, 5, 2008. Crossref
-
Kim Yong Ook, Park Hae Woong, Kim Jong Hoon, Lee Jae Young, Moon Seong Hoon, Shin Chul Soo, Anti-cancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus, Life Sciences, 79, 1, 2006. Crossref
-
Phat Chanvorleak, Li Hua, Lee Dong-Un, Moon BoKyung, Yoo Young-Bok, Lee Chan, Characterization of Hericium erinaceum powders prepared by conventional roll milling and jet milling, Journal of Food Engineering, 145, 2015. Crossref
-
Song Tuzz-Ying, Hsu Shih-Lan, Yen Gow-Chin, Induction of apoptosis in human hepatoma cells by mycelia of Antrodia camphorata in submerged culture, Journal of Ethnopharmacology, 100, 1-2, 2005. Crossref
-
De Silva Dilani D., Rapior Sylvie, Hyde Kevin D., Bahkali Ali H., Medicinal mushrooms in prevention and control of diabetes mellitus, Fungal Diversity, 56, 1, 2012. Crossref
-
Devi K. Sanjana P., Behera Birendra, Mishra Debasish, Maiti Tapas K., Immune augmentation and Dalton's Lymphoma tumor inhibition by glucans/glycans isolated from the mycelia and fruit body of Pleurotus ostreatus, International Immunopharmacology, 25, 1, 2015. Crossref
-
Pratap Ramendra, Kumar Brijesh, Ram Vishnu Ji, Substituent-induced regioselective synthesis of 1,2-teraryls and pyrano[3,4-c]pyran-4,5-diones from 2H-pyran-2-ones, Tetrahedron, 62, 34, 2006. Crossref
-
Liu Jun-Jen, Huang Tien-Shang, Hsu Ming-Ling, Chen Chin-Chu, Lin Wen-Shin, Lu Fung-Jou, Chang Wen-Huei, Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action, Toxicology and Applied Pharmacology, 201, 2, 2004. Crossref
-
Chen Y.W., Hu D.J., Cheong K.L., Li J., Xie J., Zhao J., Li S.P., Quality evaluation of lentinan injection produced in China, Journal of Pharmaceutical and Biomedical Analysis, 78-79, 2013. Crossref
-
Willard Terry, Medicinal Mushrooms, in Textbook of Natural Medicine, 2013. Crossref
-
Pratap Ramendra, Sil Diptesh, Ram Vishnu Ji, Substituent dependent regioselective synthesis of pyranopyrandiones and 1,2-teraryls from 2H-pyran-2-ones, Tetrahedron Letters, 46, 30, 2005. Crossref
-
De Silva Dilani D., Rapior Sylvie, Fons Françoise, Bahkali Ali H., Hyde Kevin D., Medicinal mushrooms in supportive cancer therapies: an approach to anti-cancer effects and putative mechanisms of action, Fungal Diversity, 55, 1, 2012. Crossref
-
Ma Li, Zhang Song, Du Mei, Cordycepin from Cordyceps militaris prevents hyperglycemia in alloxan-induced diabetic mice, Nutrition Research, 35, 5, 2015. Crossref
-
Tibuhwa Donatha Damian, A Comparative Study of Antioxidant Activities between Fresh and Dry Mushrooms in the Genera <i>Cantharellus</i> and <i>Afrocantharellus</i> from Tanzania, Food and Nutrition Sciences, 05, 02, 2014. Crossref
-
Rhim Jong-Whan, Lee Jun Ho, Drying kinetics of whole and sliced shiitake mushrooms (Lentinus edodes), Food Science and Biotechnology, 20, 2, 2011. Crossref
-
Zhang Mei, Zhang Lina, Cheung Peter C.K, Dong Jing, Fractionation and characterization of a Polysaccharide from the sclerotia of Pleurotus tuber-regium by preparative size-exclusion chromatography, Journal of Biochemical and Biophysical Methods, 56, 1-3, 2003. Crossref
-
Saltarelli Roberta, Ceccaroli Paola, Iotti Mirco, Zambonelli Alessandra, Buffalini Michele, Casadei Lucia, Vallorani Luciana, Stocchi Vilberto, Biochemical characterisation and antioxidant activity of mycelium of Ganoderma lucidum from Central Italy, Food Chemistry, 116, 1, 2009. Crossref
-
Wang Jia, Chen Haixia, Wang Yanwei, Xing Lisha, Synthesis and characterization of a new Inonotus obliquus polysaccharide-iron(III) complex, International Journal of Biological Macromolecules, 75, 2015. Crossref
-
Vinogradov Evgeny, Wasser Solomon P., The structure of a polysaccharide isolated from Inonotus levis P. Karst. mushroom (Heterobasidiomycetes), Carbohydrate Research, 340, 18, 2005. Crossref
-
Shu Chin-Hang, Lung Ming-Yeou, Effect of pH on the production and molecular weight distribution of exopolysaccharide by Antrodia camphorata in batch cultures, Process Biochemistry, 39, 8, 2004. Crossref
-
Ubaidillah Nik Hafizah Nik, Abdullah Noorlidah, Sabaratnam Vikineswary, Isolation of the intracellular and extracellular polysaccharides of Ganoderma neojaponicum (Imazeki) and characterization of their immunomodulatory properties, Electronic Journal of Biotechnology, 18, 3, 2015. Crossref
-
Seow Syntyche Ling-Sing, Eik Lee-Fang, Naidu Murali, David Pamela, Wong Kah-Hui, Sabaratnam Vikineswary, Lignosus rhinocerotis (Cooke) Ryvarden mimics the neuritogenic activity of nerve growth factor via MEK/ERK1/2 signaling pathway in PC-12 cells, Scientific Reports, 5, 1, 2015. Crossref
-
Fung Shin Yee, Tan Nget Hong, Fungi as a source of antitumour agents, in Fungal Biomolecules, 2015. Crossref
-
Han So-Ra, Kim Mi-Jin, Oh Tae-Jin, Antioxidant Activities and Antimicrobial Effects of Solvent Extracts from Lentinus edodes, Journal of the Korean Society of Food Science and Nutrition, 44, 8, 2015. Crossref
-
Wagner Ricardo, Mitchell David Alexander, Sassaki Guilherme Lanzi, Amazonas Maria Angela Lopes de Almeida, Links between morphology and physiology of Ganoderma lucidum in submerged culture for the production of exopolysaccharide, Journal of Biotechnology, 114, 1-2, 2004. Crossref
-
Abashina Tatiana, Laurinavichius Kestutis, Vainshtein Mikhail, Suppositional area for the search of bacterial products for anticancer therapy, Medical Hypotheses, 92, 2016. Crossref
-
Fernando Dilusha, Adhikari Achyut, Nanayakkara Chandrika, de Silva E Dilip, Wijesundera Ravi, Soysa Preethi, Cytotoxic effects of ergone, a compound isolated from Fulviformes fastuosus, BMC Complementary and Alternative Medicine, 16, 1, 2016. Crossref
-
Morris Humberto J., Llauradó Gabriel, Beltrán Yaixa, Lebeque Yamila, Bermúdez Rosa C., García Nora, Gaime-Perraud Isabelle, Moukha Serge, The Use of Mushrooms in the Development of Functional Foods, Drugs, and Nutraceuticals, in Wild Plants, Mushrooms and Nuts, 2016. Crossref
-
Salehi Behzad, Bayat Mansour, Dezfulian Mehrouz, Sabokbar Azar, Tabaraie Bahman, The assessment of anti-tumoral activity of polysaccharide extracted from terrestrial filamentous fungus, Saudi Journal of Biological Sciences, 25, 6, 2018. Crossref
-
YEH MING YANG, SHANG HUNG SHENG, LU HSU FENG, CHOU JASON, YEH CHUN, CHANG JIN BIOU, HUNG HSIAO FANG, KUO WAN LIN, WU LUNG YUAN, CHUNG JING GUNG, Chitosan oligosaccharides in combination with Agaricus blazei Murill extract reduces hepatoma formation in mice with severe combined immunodeficiency, Molecular Medicine Reports, 12, 1, 2015. Crossref
-
Uluköy Gülşen, Baba Esİn, Öntaş Canan, Effect of Oyster Mushroom, Pleurotus ostreatus , Extract on Hemato-Immunological Parameters of Rainbow Trout, Oncorhynchus mykiss , Journal of the World Aquaculture Society, 47, 5, 2016. Crossref
-
Suabjakyong Papawee, Saiki Ryotaro, Van Griensven Leo J. L. D., Higashi Kyohei, Nishimura Kazuhiro, Igarashi Kazuei, Toida Toshihiko, Arai Ken, Polyphenol Extract from Phellinus igniarius Protects against Acrolein Toxicity In Vitro and Provides Protection in a Mouse Stroke Model, PLOS ONE, 10, 3, 2015. Crossref
-
Sari Miriam, Prange Alexander, Lelley Jan I., Hambitzer Reinhard, Screening of beta-glucan contents in commercially cultivated and wild growing mushrooms, Food Chemistry, 216, 2017. Crossref
-
Meng Xin, Liang Hebin, Luo Lixin, Antitumor polysaccharides from mushrooms: a review on the structural characteristics, antitumor mechanisms and immunomodulating activities, Carbohydrate Research, 424, 2016. Crossref
-
Aboutabl Elsayed Ali, Elsawi Salma Ahmed, Rashed Khaled Nabih, Ragab Nermin Ahmed, Composition of polysaccharides fromAlectryon tomentosusF. Muell. leaves with potential cytotoxic and antimicrobial activities, Starch - Stärke, 68, 9-10, 2016. Crossref
-
Smina T.P., Nitha B., Devasagayam T.P.A, Janardhanan K.K., Ganoderma lucidum total triterpenes induce apoptosis in MCF-7 cells and attenuate DMBA induced mammary and skin carcinomas in experimental animals, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 813, 2017. Crossref
-
Ashfaque A. Khaskheli, Shahzor G. Khaskheli, Ying Liu, Saghir A. Sheikh, Yan-Feng Wang, Aijaz H. Soomro, Xiaojiu Tian, Mamoun A. Homaida, Wen Huang, Optimization of enzyme assisted extraction of polysaccharides from Poria cocos, Journal of Medicinal Plants Research, 11, 17, 2017. Crossref
-
Kojić Jovana R. Stefanović, Vrvić Miroslav M., Gojgić-Cvijović Gordana Đ., Beškoski Vladimir P., Jakovljević Dragica M., Microbial Polysaccharides: Between Oil Wells, Food and Drugs, in Emerging and Traditional Technologies for Safe, Healthy and Quality Food, 2016. Crossref
-
Wasser Solomon P., Medicinal Properties and Clinical Effects of Medicinal Mushrooms, in Edible and Medicinal Mushrooms, 2017. Crossref
-
Maruca Annalisa, Moraca Federica, Rocca Roberta, Molisani Fulvia, Alcaro Francesca, Gidaro Maria, Alcaro Stefano, Costa Giosuè, Ortuso Francesco, Chemoinformatic Database Building and in Silico Hit-Identification of Potential Multi-Targeting Bioactive Compounds Extracted from Mushroom Species, Molecules, 22, 9, 2017. Crossref
-
WISBECK ELISABETH, FACCHINI JEAN M., ALVES ENDI P., SILVEIRA MARCIA L.L., GERN REGINA M.M., NINOW JORGE L., FURLAN SANDRA A., A polysaccharide fraction extracted from Pleurotus ostreatus mycelial biomass inhibit Sarcoma 180 tumor, Anais da Academia Brasileira de Ciências, 89, 3 suppl, 2017. Crossref
-
Abdullah Noorlidah, Abdulghani Rosnina, Ismail Siti Marjiana, Abidin Mohamad Hamdi Zainal, Immune-stimulatory potential of hot water extracts of selected edible mushrooms, Food and Agricultural Immunology, 28, 3, 2017. Crossref
-
Zhang Y, Wang P, Xiao Y, Wang X, Yang S, Liu Q, Chemical compositions and antiproliferation activities of the chloroform fraction from Pyropolyporus fomentarius in K562 cells, Human & Experimental Toxicology, 34, 7, 2015. Crossref
-
Tsai Cheng-Chih, Li Yu-Sheng, Lin Pei-Pei, Inonotus obliquus extract induces apoptosis in the human colorectal carcinoma’s HCT-116 cell line, Biomedicine & Pharmacotherapy, 96, 2017. Crossref
-
Lemieszek Marta Kinga, Ribeiro Miguel, Marques Guilhermina, Nunes Fernando Milheiro, Pożarowski Piotr, Rzeski Wojciech, New insights into the molecular mechanism of Boletus edulis ribonucleic acid fraction (BE3) concerning antiproliferative activity on human colon cancer cells, Food Funct., 8, 5, 2017. Crossref
-
Raghavendra Vinay Basavegowda, Venkitasamy Chandrasekar, Pan Zhongli, Nayak Chandra, Functional Foods from Mushroom, in Microbial Functional Foods and Nutraceuticals, 2017. Crossref
-
Zainal-Abidin Mohamad Hamdi, Hayyan Maan, Hayyan Adeeb, Jayakumar Natesan Subramanian, New horizons in the extraction of bioactive compounds using deep eutectic solvents: A review, Analytica Chimica Acta, 979, 2017. Crossref
-
Friedman Mendel, Mushroom Polysaccharides: Chemistry and Antiobesity, Antidiabetes, Anticancer, and Antibiotic Properties in Cells, Rodents, and Humans, Foods, 5, 4, 2016. Crossref
-
Khan Asma Ashraf, Gani Adil, Khanday Firdous A., Masoodi F.A., Biological and pharmaceutical activities of mushroom β-glucan discussed as a potential functional food ingredient, Bioactive Carbohydrates and Dietary Fibre, 16, 2018. Crossref
-
HAHNE JENS C., MEYER SUSANNE R., DIETL JOHANNES, HONIG ARND, The effect of Cordyceps extract and a mixture of Ganoderma lucidum/Agaricus Blazi Murill extract on human endometrial cancer cell lines in vitro, International Journal of Oncology, 45, 1, 2014. Crossref
-
Ajith Thekkuttuparambil A., Janardhanan Kainoor K., Indian Medicinal Mushrooms as a Source of Antioxidant and Antitumor Agents, Journal of Clinical Biochemistry and Nutrition, 40, 3, 2007. Crossref
-
Vasdekis Efstathios P., Karkabounas Athanassios, Giannakopoulos Ioannis, Savvas Dimitrios, Lekka Marilena E., Screening of mushrooms bioactivity: piceatannol was identified as a bioactive ingredient in the order Cantharellales, European Food Research and Technology, 244, 5, 2018. Crossref
-
Liu Yanrong, Zhao Jianmin, Zhao Yali, Zong Shumin, Tian Yixuan, Chen Shuang, Li Meng, Liu Huijuan, Zhang Qiang, Jing Xueshuang, Sun Bo, Wang Hongzhi, Sun Tao, Yang Cheng, Therapeutic effects of lentinan on inflammatory bowel disease and colitis-associated cancer, Journal of Cellular and Molecular Medicine, 23, 2, 2019. Crossref
-
Yong Tianqiao, Chen Shaodan, Xie Yizhen, Chen Diling, Su Jiyan, Shuai Ou, Jiao Chunwei, Zuo Dan, Cordycepin, a Characteristic Bioactive Constituent in Cordyceps militaris, Ameliorates Hyperuricemia through URAT1 in Hyperuricemic Mice, Frontiers in Microbiology, 9, 2018. Crossref
-
Hereher Faten, ElFallal Amira, Toson Elshahat, Abou-Dobara Mohammed, Antitumor effect of a crude protein-bound polysaccharide substance extracted from Volvariella speciosa, Bioactive Carbohydrates and Dietary Fibre, 16, 2018. Crossref
-
Bao Hong Hui, Tarbasa Mehdi, Chae Hee Mun, You Sang Guan, Molecular Properties of Water-Unextractable Proteoglycans from Hypsizygus marmoreus and Their in Vitro Immunomodulatory Activities, Molecules, 17, 1, 2011. Crossref
-
Jeong Sang Chul, Koyyalamudi Sundar Rao, Jeong Yong Tae, Song Chi Hyun, Pang Gerald, Macrophage Immunomodulating and Antitumor Activities of Polysaccharides Isolated fromAgaricus bisporusWhite Button Mushrooms, Journal of Medicinal Food, 15, 1, 2012. Crossref
-
Yi Wenhui, Zhang Ping, Hou Jin, Chen Weiping, Bai Lei, Yoo Sweejiang, Khalid Asif, Hou Xun, Enhanced response of tamoxifen toward the cancer cells using a combination of chemotherapy and photothermal ablation induced by lentinan-functionalized multi-walled carbon nanotubes, International Journal of Biological Macromolecules, 120, 2018. Crossref
-
Sukumar Dandapat, TOXICITY OF SILVER NANOPARTICLES LOADED WITH Pleurotus tuber-regium EXTRACT ON RATS, Biotechnologia Acta, 12, 3, 2019. Crossref
-
Oyetayo F.L., Akindahunsi A.A, Oyetayo V.O., Chemical Profile and Amino Acids Composition of Edible Mushrooms Pleurotus sajor-caju, Nutrition and Health, 18, 4, 2007. Crossref
-
Wu Jian-Yong, Polysaccharide-Protein Complexes from Edible Fungi and Applications, in Polysaccharides, 2014. Crossref
-
Lemieszek Marta K., Nunes Fernando M., Rzeski Wojciech, Branched mannans from the mushroom Cantharellus cibarius enhance the anticancer activity of natural killer cells against human cancers of lung and colon, Food & Function, 10, 9, 2019. Crossref
-
Zainal‐Abidin Mohamad H., Hayyan Maan, Ngoh Gek C., Wong Won F., Hayyan Adeeb, Extraction of Bioactive Compounds, in Deep Eutectic Solvents, 2019. Crossref
-
Philippoussis Antonios N., Production of Mushrooms Using Agro-Industrial Residues as Substrates, in Biotechnology for Agro-Industrial Residues Utilisation, 2009. Crossref
-
Patanapongpibul Manee, Chen Qiao-Hong, Immune Modulation of Asian Folk Herbal Medicines and Related Chemical Components for Cancer Management, Current Medicinal Chemistry, 26, 17, 2019. Crossref
-
da Silva de Souza Aline Cristine, Correa Vanesa Gesser, Goncalves Geferson de Almeida, Soares Andreia Assuncao, Bracht Adelar, Peralta Rosane Marina, Agaricus blazei Bioactive Compounds and their Effects on Human Health: Benefits and Controversies, Current Pharmaceutical Design, 23, 19, 2017. Crossref
-
Karuppaiya Palaniyandi, Akbar Abdul Khader, Mycotherapy of Antrodia salmonea: A Taiwanese Medicinal Mushroom, in Medicinal Mushrooms, 2019. Crossref
-
Ramesh Sindhu, Majrashi Mohammed, Almaghrabi Mohammed, Govindarajulu Manoj, Fahoury Eddie, Fadan Maali, Buabeid Manal, Deruiter Jack, Clark Randall, Mulabagal Vanisree, Agrawal Dinesh Chandra, Moore Timothy, Dhanasekaran Muralikrishnan, Overview of Therapeutic Efficacy of Mushrooms, in Medicinal Mushrooms, 2019. Crossref
-
Lakhanpal T.N., Rana Monika, Medicinal and nutraceutical genetic resources of mushrooms, Plant Genetic Resources, 3, 2, 2005. Crossref
-
Nandi Sudeshna, Sikder Rimpa, Acharya Krishnendu, Secondary Metabolites of Mushrooms: A Potential Source for Anticancer Therapeutics with Translational Opportunities, in Advancing Frontiers in Mycology & Mycotechnology, 2019. Crossref
-
Fu Youli, Shi Lei, Ding Kan, Structure elucidation and anti-tumor activity in vivo of a polysaccharide from spores of Ganoderma lucidum (Fr.) Karst, International Journal of Biological Macromolecules, 141, 2019. Crossref
-
Berovic Marin, Cultivation of Medicinal Mushroom Biomass by Solid-State Bioprocessing in Bioreactors, in Solid State Fermentation, 169, 2019. Crossref
-
Joseph Soniamol, Sabulal Baby, George Varughese, Antony Kuttikkadan, Janardhanan Kainoor, Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum, Acta Pharmaceutica, 61, 3, 2011. Crossref
-
Das Banani, De Biplab, Chetree Rishiraj, Mandal Subhash C., Medicinal Aspect of Mushrooms: A View Point, in Herbal Medicine in India, 2020. Crossref
-
Ma Haile, Jia Jingdun, Ge Yiqiang, He Ronghai, Zhou Cunshan, Wei Xun, Qu Wenjuan, Wang Bei, Wu Bengang, Sun Ling, Wang Zhenbin, Zhang Yanyan, Zhang Henan, Olayemi Oladejo Ayobami, Pan Zhongli, Yin Xiulian, The Basic Concept and Research Progress of Food Physical Processing, in Advances in Food Processing Technology, 2019. Crossref
-
Uddin Pk Moyen, Pervin Rumana, Jahan Jabin, Islam Talukder Rabiul, Ahmed Sourav, Rahman Matiar, Mushroom Polysaccharides: Chemistry and Anticancer Potentials, in An Introduction to Mushroom, 2020. Crossref
-
Barros Ana, Bell Vitoria, Ferrão Jorge, Calabrese Vittorio, Fernandes Tito, Mushroom Biomass: Some Clinical Implications of β-Glucans and Enzymes, Current Research in Nutrition and Food Science Journal, 4, Special-Issue-Oc, 2016. Crossref
-
Zhao Shuang, Gao Qi, Rong Chengbo, Wang Shouxian, Zhao Zhekun, Liu Yu, Xu Jianping, Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products, Journal of Fungi, 6, 4, 2020. Crossref
-
Jakopovic Boris, Horvatić Anita, Klobučar Marko, Gelemanović Andrea, Grbčić Petra, Oršolić Nada, Jakopovich Ivan, Kraljević Pavelić Sandra, Treatment With Medicinal Mushroom Extract Mixture Inhibits Translation and Reprograms Metabolism in Advanced Colorectal Cancer Animal Model as Evidenced by Tandem Mass Tags Proteomics Analysis, Frontiers in Pharmacology, 11, 2020. Crossref
-
Prabhakar Pranav Kumar, Hypoglycemic potential of mushroom and their metabolites, in New and Future Developments in Microbial Biotechnology and Bioengineering, 2020. Crossref
-
Vetchinkina Elena, Fomin Alexander, Navolokin Nikita, Shirokov Alexander, Proteins and polysaccharides from vegetative mycelium of medicinal basidiomycete Lentinus edodes display cytotoxicity towards human and animal cancer cell lines, International Journal of Biological Macromolecules, 195, 2022. Crossref
-
Lee Jun Ho, Lee Min Ji, Effect of drying method on the moisture sorption isotherms for Inonotus obliquus mushroom, LWT - Food Science and Technology, 41, 8, 2008. Crossref
-
Mirończuk-Chodakowska Iwona, Kujawowicz Karolina, Witkowska Anna Maria, Beta-Glucans from Fungi: Biological and Health-Promoting Potential in the COVID-19 Pandemic Era, Nutrients, 13, 11, 2021. Crossref
-
Xing Jie, Liu Zhenguang, Huang Yifan, Qin Tao, Bo Ruonan, Zheng Sisi, Luo Li, Huang Yee, Niu Yale, Wang Deyun, Lentinan-Modified Carbon Nanotubes as an Antigen Delivery System Modulate Immune Response in Vitro and in Vivo, ACS Applied Materials & Interfaces, 8, 30, 2016. Crossref
-
Bolaniran Tolulope, Jamiu Abdullahi Temitope, Garuba Taofeeq, Wudil Alhassan Muhammad, Adeola Henry Ademola, Sabiu Saheed, An appraisal of the metabolites, pharmacological and biotechnological significance of edible mushrooms, Transactions of the Royal Society of South Africa, 76, 3, 2021. Crossref
-
Öztürk Mehmet, Tel-Çayan Gülsen, Çayan Fatih, Duru Mehmet Emin, Promising Small Molecules Against Cancer from Ganoderma Genus, in Biodiversity, Conservation and Sustainability in Asia, 2021. Crossref
-
Ullah A., Azmat H., Masood Z., Arooj F., Hussain S. M., Malik A., Impact of dietary leaf extracts of Black pepper Piper nigrum L. on the growth, hematological and immunological parameters of Labeo rohita (Hamilton, 1822) cultured in glass aquaria, Brazilian Journal of Biology, 83, 2023. Crossref
-
Salwan Richa, Katoch Shabnam, Sharma Vivek, Recent Developments in Shiitake Mushrooms and Their Nutraceutical Importance, in Fungi in Sustainable Food Production, 2021. Crossref
-
Wang Chung-Huang, Hsieh Shu-Chen, Wang Huei-Ju, Chen Miaw-Ling, Lin Bi-Fong, Chiang Been-Huang, Lu Ting-Jang, Concentration Variation and Molecular Characteristics of Soluble (1,3;1,6)-β-d-Glucans in Submerged Cultivation Products of Ganoderma lucidum Mycelium, Journal of Agricultural and Food Chemistry, 62, 3, 2014. Crossref
-
Chen Shiuan, Oh Sei-Ryang, Phung Sheryl, Hur Gene, Ye Jing Jing, Kwok Sum Ling, Shrode Gayle E., Belury Martha, Adams Lynn S., Williams Dudley, Anti-Aromatase Activity of Phytochemicals in White Button Mushrooms (Agaricus bisporus), Cancer Research, 66, 24, 2006. Crossref
-
Wang Ying, Jin Hongyu, Yu Jiandong, Qu Changhai, Wang Qi, Yang Shuang, Ma Shuangcheng, Ni Jian, Quality control and immunological activity of lentinan samples produced in China, International Journal of Biological Macromolecules, 159, 2020. Crossref
-
Ponnusamy Chandrasekaran, Uddandrao V V Sathibabu, Pudhupalayam Sethumathi Ponnusamy, Singaravel Sengottuvelu, Periyasamy Tamilmani, Ponnusamy Ponmurugan, Prabhu Puniethaa, Sasikumar Vadivukkarasi, Ganapathy Saravanan, Lentinula Edodes (Edible Mushroom) as a Nutraceutical: A Review, Biosciences Biotechnology Research Asia, 19, 1, 2022. Crossref
-
Fares Fuad, Khatib Soliman, Vaya Jacob, Sharvit Lital, Eizenberg Einav, Wasser Solomon, Striatal Isolated from Cyathus striatus Extracts Induces Apoptosis in Human Pancreatic Cancer Cells, Molecules, 27, 9, 2022. Crossref
-
Panda Mrunmaya K., Paul Manish, Singdevsachan Sameer K., Tayung Kumananda, Das Swagat K., Thatoi Hrudayanath, Promising Anti-cancer Therapeutics From Mushrooms: Current Findings and Future Perceptions, Current Pharmaceutical Biotechnology, 22, 9, 2021. Crossref
-
Lung Ming-Yu, Deng Kai-Wen, Improved Production and Insulinotropic Properties of Exopolysaccharide by Phellinus igniarius in Submerged Cultures, Processes, 10, 2, 2022. Crossref
-
Sivanesan Iyyakkannu, Muthu Manikandan, Gopal Judy, Oh Jae-Wook, Mushroom Polysaccharide-Assisted Anticarcinogenic Mycotherapy: Reviewing Its Clinical Trials, Molecules, 27, 13, 2022. Crossref
-
Kawashte Ganesh, Sonawane Hiralal, Mittal Smriti, Borde Mahesh, Medicinal Fungi: A Natural Source of Pharmacologically Important Metabolites, in Recent Developments in Microbial Technologies, 2021. Crossref
-
da Silva Nascimento Santos Marília, Leite Edda Lisboa, Polysaccharides from the Fungus Scleroderma/Fungi, in Polysaccharides, 2014. Crossref
-
Tian Run, Chai Hui, Qiu Jun-Qiang, Liang Zhi-Qun, Xie Hui-Jing, Wang Yong, Zeng Nian-Kai, Preparation, structural characterisation, and antioxidant activities of polysaccharides from eight boletes (Boletales) in tropical China, Mycology, 13, 3, 2022. Crossref
-
Park Hye-Jin, Current Uses of Mushrooms in Cancer Treatment and Their Anticancer Mechanisms, International Journal of Molecular Sciences, 23, 18, 2022. Crossref
-
You Hong, Abraham Evelyn J., Mulligan Jason, Zhou Yucheng, Montoya Maureen, Willig Jennifer, Chen Bo-Kai, Wang Chin-Kun, Wang Li-Shu, Dong Athena, Shamtsyan Mark, Nguyen Haiuyen, Wong Andrea, Wallace Taylor C., Label compliance for ingredient verification: regulations, approaches, and trends for testing botanical products marketed for “immune health” in the United States, Critical Reviews in Food Science and Nutrition, 2022. Crossref