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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Vanadate Induces G2/M Phase Arrest in p53-Deficient Mouse Embryo Fibroblasts

Volume 21, Issue 3, 2002, 9 pages
DOI: 10.1615/JEnvironPatholToxicolOncol.v21.i3.30
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ABSTRACT

Vanadium compounds exert potent toxic and carcinogenic effects on a wide variety of biological systems. The mechanisms involved in their toxicity and carcinogenesis require investigation. Cell growth arrest and its regulation are important mechanisms in maintaining genomic stability and integrity in response to environmental stress. The p53 tumor suppressor plays a central role in the regulation of the normal cell cycle. To investigate the role ofp53 in vanadate-induced cell growth arrest and its regulation, two cell lines— normal mouse embryo fibroblasts [p53(+/+)] and p53-deficient mouse embryo fibroblasts [p53(-/-)],— were used in this study. Flow cytometry was used to analyze cell growth arrest at G0/G1, S, or G2/M phase. Western blotting analysis was performed to determine several cell growth regulatory proteins. The results showed that in p53(-/-) cells vanadate induced G2/M phase arrest in a dose- and time-dependent manner without alteration of S phase. In p53(+/+) cells, vanadate treatment increased the S phase with no significant change in the G2/M phase. Furthermore, Western blotting results showed that in p53(-/-) cells vanadate caused cdc25C degradation and activation ofphospho-cdc2 without alteration of the p21 level. In p53(+/+) cells, vanadate increased the expression of p21 and degraded cdc25A instead of cdc25C without any effect on cdc2. These results demonstrate that vanadate induced G2/M phase arrest in p53-deficient mouse embryo fibroblasts, and promoted S phase entry in p53 wild-type mouse embryo fibroblasts.

CITED BY
  1. Petanidis Savvas, Kioseoglou Efrosini, Hadzopoulou-Cladaras Margarita, Salifoglou Athanasios, Novel ternary vanadium-betaine-peroxido species suppresses H-ras and matrix metalloproteinase-2 expression by increasing reactive oxygen species-mediated apoptosis in cancer cells, Cancer Letters, 335, 2, 2013. Crossref

  2. Pessoa Joao Costa, Etcheverry Susana, Gambino Dinorah, Vanadium compounds in medicine, Coordination Chemistry Reviews, 301-302, 2015. Crossref

  3. Zwolak Iwona, Vanadium carcinogenic, immunotoxic and neurotoxic effects: a review ofin vitrostudies, Toxicology Mechanisms and Methods, 24, 1, 2014. Crossref

  4. Khalil A. A., Jameson M. J., Sodium orthovanadate inhibits proliferation and triggers apoptosis in oral squamous cell carcinoma in vitro, Biochemistry (Moscow), 82, 2, 2017. Crossref

  5. Del Carpio Edgar, Hernández Lino, Ciangherotti Carlos, Villalobos Coa Valentina, Jiménez Lissette, Lubes Vito, Lubes Giuseppe, Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications, Coordination Chemistry Reviews, 372, 2018. Crossref

  6. Treviño Samuel, Díaz Alfonso, Sánchez-Lara Eduardo, Sanchez-Gaytan Brenda L., Perez-Aguilar Jose Manuel, González-Vergara Enrique, Vanadium in Biological Action: Chemical, Pharmacological Aspects, and Metabolic Implications in Diabetes Mellitus, Biological Trace Element Research, 188, 1, 2019. Crossref

  7. Zhang Yue, Wang Lichao, Zeng Kewu, Wang Kui, Yang Xiaoda, Vanadyl complexes discriminate between neuroblastoma cells and primary neurons by inducing cell-specific apoptotic pathways, Journal of Inorganic Biochemistry, 188, 2018. Crossref

  8. Assem Farida Louise, Levy Leonard Stephen, Inhalation Toxicity of Vanadium, in Vanadium, 2012. Crossref

  9. Pisano Marina, Arru Claudia, Serra Maria, Galleri Grazia, Sanna Daniele, Garribba Eugenio, Palmieri Giuseppe, Rozzo Carla, Antiproliferative activity of vanadium compounds: effects on the major malignant melanoma molecular pathways, Metallomics, 11, 10, 2019. Crossref

  10. Zhang Jingjie, Gao Guangxun, Chen Liang, Deng Xu, Li Jingxia, Yu Yonghui, Zhang Dongyun, Li Fei, Zhang Min, Zhao Qinshi, Huang Chuanshu, Cheliensisin A Inhibits EGF-Induced Cell Transformation with Stabilization of p53 Protein Via a Hydrogen Peroxide/Chk1-Dependent Axis, Cancer Prevention Research, 6, 9, 2013. Crossref

  11. Wang Jian, Ouyang Weiming, Li Jingxia, Wei Lixin, Ma Qian, Zhang Zhuo, Tong Qiangsong, He Jie, Huang Chuanshu, Loss of Tumor Suppressor p53 Decreases PTEN Expression and Enhances Signaling Pathways Leading to Activation of Activator Protein 1 and Nuclear Factor κB Induced by UV Radiation, Cancer Research, 65, 15, 2005. Crossref

  12. Zhu Junlan, Zhang Jingjie, Huang Haishan, Li Jingxia, Yu Yonghui, Jin Honglei, Li Yang, Deng Xu, Gao Jimin, Zhao Qinshi, Huang Chuanshu, Crucial Role of c-Jun Phosphorylation at Ser63/73 Mediated by PHLPP Protein Degradation in the Cheliensisin A Inhibition of Cell Transformation, Cancer Prevention Research, 7, 12, 2014. Crossref

  13. Rozzo Carla, Sanna Daniele, Garribba Eugenio, Serra Maria, Cantara Alessio, Palmieri Giuseppe, Pisano Marina, Antitumoral effect of vanadium compounds in malignant melanoma cell lines, Journal of Inorganic Biochemistry, 174, 2017. Crossref

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