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Journal of Environmental Pathology, Toxicology and Oncology

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ISSN Online: 2162-6537

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Nanoparticles in Daily Life: Applications, Toxicity and Regulations

Volume 37, Issue 3, 2018, pp. 209-230
DOI: 10.1615/JEnvironPatholToxicolOncol.2018026009
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Ritu Gupta
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA
Huan Xie
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA

ABSTRACT

At nanoscale, man-made materials may show unique properties that differ from bulk and dissolved counterparts. The unique properties of engineered nanomaterials not only impart critical advantages but also confer toxicity because of their unwanted interactions with different biological compartments and cellular processes. In this review, we discuss various entry routes of nanomaterials in the human body, their applications in daily life, and the mechanisms underlying their toxicity. We further explore the passage of nanomaterials into air, water, and soil ecosystems, resulting in diverse environmental impacts. Briefly, we probe the available strategies for risk assessment and risk management to assist in reducing the occupational risks of potentially hazardous engineered nanomaterials including the control banding (CB) approach. Moreover, we substantiate the need for uniform guidelines for systematic analysis of nanomaterial toxicity, in silico toxicological investigations, and obligation to ensure the safe disposal of nanowaste to reduce or eliminate untoward environmental and health impacts. At the end, we scrutinize global regulatory trends, hurdles, and efforts to develop better regulatory sciences in the field of nanomedicines.

KEY WORDS: engineered nanoparticles, entry routes, environmental impact, nanowaste, disposal, control banding
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Chemotherapeutic Drugs Endow Gastric Cancer Mesenchymal Stem Cells with Stronger Tumor-Promoting Ability Jiaqi Shen, Chao Huang, Linjing Cui, Yuanyuan Zhao, Miaolin Zhu, Zhihong Chen, Mei Wang, Wei Zhu, Bo Shen The Mutational and Transcriptional Landscapes of Speckle-Type POZ Protein (SPOP) and Androgen Receptor (AR) in a Single-Center pT3 Prostatectomy Cohort Isil Ezgi Eryilmaz, Berna Aytac Vuruskan, Onur Kaygisiz, Gulsah Cecener, Unal Egeli, Hakan Vuruskan Whole-Genome Comparative Copy Number Alteration Profiling between Malignant Pleural Mesothelioma and Asbestos-Induced Chronic Pleuritis Tunç Tuncel, Muzaffer Metintas, AK Güntülü, Hasan Veysi Güneş Comprehensive Investigation of m6A Regulators for Prognosis in Head and Neck Squamous Cell Carcinoma Jingning Cheng, Yong Lyu, Ziyan Cheng

Forthcoming Articles

A systems biology approach unveils a critical role of DPP4 in upper gastrointestinal cancer patient outcomes Sudhir Kotnala, Anupam Dhasmana, Swati Dhasmana, Shafiul Haque, Murali Yallapu, Manish Tripathi, Meena Jaggi, Subhash Chauhan Complex Genomic Rearrangement Patterns in Malignant Pleural Mesothelioma due to Environmental Asbestos Exposure Tunç Tuncel, Güntülü Ak, Hasan Veysi Güneş, Muzaffer Metintaş TFR1-mediated iron metabolism orchestrates tumor ferroptosis and immunity in non-small cell lung cancer Zunqiao Wang, Xingkai Yao, Keping Wang, Bin Wang Can the toxic heavy metals be beneficial at trace levels? Understanding their outreached biological functions Sanjib Bhattacharya Transcription Factor E2F1 Enhances Hepatocellular Carcinoma Cell Proliferation and Stemness by Activating GINS1 Xuefeng Ren, Lianqiang Shen, Shan Gao Frequency of Healthy Control Genotype of VDR Gene Polymorphisms in the Saudi Population of Ha’il Region: A Comparative Study with Worldwide Population Mahvish Khan, Nashwa Bushara, Manoj Kumar, Raju Mandal, Saheem Ahmad, Saif Khan Withaferin A encapsulated PEGylated nanoliposome induces apoptosis in B16f10 melanoma cells by regulating Bcl2 and Bcl xl genes and mitigates murine solid tumor development Prathapan Abeesh, Chandrasekharan Guruvayoorappan Comprehensive Investigation of m6A Regulators for Prognosis in Head and Neck Squamous Cell Carcinoma Jingning Cheng, Yong Lyu, Ziyan Cheng
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