Published 4 issues per year
ISSN Print: 0731-8898
ISSN Online: 2162-6537
IF:
2.4
5-Year IF:
2.8
Immediacy Index:
0.5
Eigenfactor:
0.00049
JCI:
0.59
SJR:
0.429
SNIP:
0.507
CiteScore™::
3.9
H-Index:
49
Indexed in
Redox Status-Dependent Regulation of Cyclooxygenases Mediates the Capsaicin-Induced Apoptosis in Human Neuroblastoma Cells
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ABSTRACT
Cyclooxygenases (COX) appear to be involved in the mechanism of apoptosis in various cancer cells. In this study we investigated the role of COX in the capsaicin (Cap)-induced apoptosis in SK-N-SH human neuroblastoma cells. Cap induced decreased cell viability and apoptosis in a dose-dependent manner. Cap also significantly reduced the basal generation of reactive oxygen species (ROS) and lipid peroxidation in a time-dependent fashion. Cap markedly suppressed the expression of COX-1 and COX-2. Pretreatment with NS-398, a selective COX-2 inhibitor, or indomethacin, a nonselective COX inhibitor, significantly enhanced the Cap-induced decreased cell viability and apoptosis. Exogenous application of an oxidant, Н2О2, significantly prevented the Cap-induced apoptosis and suppressed the expression of COX isoforms. These results suggest that redox status-dependent regulation of COX expression may mediate apoptosis induced by Cap in human neuroblastoma cells.
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Baek Yu Mi, Hwang Hye Jin, Kim Sang Woo, Hwang Hee Sun, Lee Sung Hak, Kim Jung Ae, Yun Jong Won, A comparative proteomic analysis for capsaicin-induced apoptosis between human hepatocarcinoma (HepG2) and human neuroblastoma (SK-N-SH) cells, PROTEOMICS, 8, 22, 2008. Crossref
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Meghvansi M.K., Siddiqui S., Khan Md. Haneef, Gupta V.K., Vairale M.G., Gogoi H.K., Singh Lokendra, Naga chilli: A potential source of capsaicinoids with broad-spectrum ethnopharmacological applications, Journal of Ethnopharmacology, 132, 1, 2010. Crossref
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Sun Zewei, Han Jie, Zhao Wenting, Zhang Yuanyuan, Wang Shuai, Ye Lifang, Liu Tingting, Zheng Liangrong, TRPV1 Activation Exacerbates Hypoxia/Reoxygenation-Induced Apoptosis in H9C2 Cells via Calcium Overload and Mitochondrial Dysfunction, International Journal of Molecular Sciences, 15, 10, 2014. Crossref
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Lin Ming-Hung, Lee Yi-Hui, Cheng Hsiao-Ling, Chen Huei-Yu, Jhuang Fong-Han, Chueh Pin, Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1), Molecules, 21, 7, 2016. Crossref
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Pandey Manoj K., Gupta Subash C., Nabavizadeh Ali, Aggarwal Bharat B., Regulation of cell signaling pathways by dietary agents for cancer prevention and treatment, Seminars in Cancer Biology, 46, 2017. Crossref
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Murray Michael T., Capsicum frutescens (Cayenne Pepper), in Textbook of Natural Medicine, 2020. Crossref
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Bley Keith, Boorman Gary, Mohammad Bashir, McKenzie Donald, Babbar Sunita, A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin, Toxicologic Pathology, 40, 6, 2012. Crossref
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Bhutani Manisha, Pathak Ashutosh K., Nair Asha S., Kunnumakkara Ajaikumar B., Guha Sushovan, Sethi Gautam, Aggarwal Bharat B., Capsaicin Is a Novel Blocker of Constitutive and Interleukin-6–Inducible STAT3 Activation, Clinical Cancer Research, 13, 10, 2007. Crossref
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Samadi Abbas K., Bilsland Alan, Georgakilas Alexandros G., Amedei Amedeo, Amin Amr, Bishayee Anupam, Azmi Asfar S., Lokeshwar Bal L., Grue Brendan, Panis Carolina, Boosani Chandra S., Poudyal Deepak, Stafforini Diana M., Bhakta Dipita, Niccolai Elena, Guha Gunjan, Vasantha Rupasinghe H.P., Fujii Hiromasa, Honoki Kanya, Mehta Kapil, Aquilano Katia, Lowe Leroy, Hofseth Lorne J., Ricciardiello Luigi, Ciriolo Maria Rosa, Singh Neetu, Whelan Richard L., Chaturvedi Rupesh, Ashraf S. Salman, Shantha Kumara H.M.C., Nowsheen Somaira, Mohammed Sulma I., Keith W. Nicol, Helferich William G., Yang Xujuan, A multi-targeted approach to suppress tumor-promoting inflammation, Seminars in Cancer Biology, 35, 2015. Crossref