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Journal of Environmental Pathology, Toxicology and Oncology

Published 4 issues per year

ISSN Print: 0731-8898

ISSN Online: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

MNU-Induced Rat Mammary Carcinomas: Immunohistology and Estrogen Receptor Expression

Volume 32, Issue 2, 2013, pp. 157-163
DOI: 10.1615/JEnvironPatholToxicolOncol.2013007541
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ABSTRACT

Environmental exposure to nitrosamines is associated with the development of cancer in a variety of target organs. One such carcinogen, N-methyl-N-nitrosurea (MNU), has long been used to induce mammary tumors in rats, which provide a useful model to study mammary carcinogenesis. However, some poorly clarified issues remain, such as the lack of a clear description of morphological patterns of tumors and the distribution and role of estrogen receptors (ERs) during tumor progression, as tumors overexpressing ERs show a paradoxical tendency to recur after ovariectomy.
Mammary carcinomas were induced in Sprague-Dawley rats using MNU. The tumors were studied histologically and distribution of smooth muscle actin and ERs was studied immunohistochemically. All tumors presented both an epithelial and a myoepithelial component, demonstrated by immunohistochemical detection of smooth muscle actin. Tumors showed distinct histological patterns: well-differentiated papillary and adenoid areas and poorly differentiated solid and spindle-cell foci. Overexpression of ERs (>75% of labelled cells vs. 0−75% in control tissue) occurred in papillary and adenoid areas but not in solid and spindle-cell foci. Poorly differentiated tumor foci are likely to represent a more advanced, estrogen-independent phase in cancer progression and constitute the basis for tumor recurrence after ovariectomy.

CITED BY
  1. Faustino-Rocha Ana I., Ferreira Rita, Oliveira Paula A., Gama Adelina, Ginja Mário, N-Methyl-N-nitrosourea as a mammary carcinogenic agent, Tumor Biology, 36, 12, 2015. Crossref

  2. Faustino-Rocha Ana I., Calado Ana M., Gama Adelina, Ferreira Rita, Ginja Mário, Oliveira Paula A., Electron Microscopy Findings inN-Methyl-N-Nitrosourea-Induced Mammary Tumors, Microscopy and Microanalysis, 22, 5, 2016. Crossref

  3. Faustino-Rocha Ana I., Ferreira Rita, Gama Adelina, Oliveira Paula A., Ginja Mário, Antihistamines as promising drugs in cancer therapy, Life Sciences, 172, 2017. Crossref

  4. Padrão A. I., Figueira A. C. C., Faustino-Rocha A. I., Gama A., Loureiro M. M., Neuparth M. J., Moreira-Gonçalves D., Vitorino R., Amado F., Santos L. L., Oliveira P. A., Duarte J. A., Ferreira R., Long-term exercise training prevents mammary tumorigenesis-induced muscle wasting in rats through the regulation of TWEAK signalling, Acta Physiologica, 219, 4, 2017. Crossref

  5. Crismale-Gann Catina, Stires Hillary, Katz Tiffany A., Cohick Wendie S., Tumor Phenotype and Gene Expression During Early Mammary Tumor Development in Offspring Exposed to Alcohol In Utero, Alcoholism: Clinical and Experimental Research, 40, 8, 2016. Crossref

  6. Yaacob Nik Soriani, Yankuzo Hassan Muhammad, Devaraj Sutha, Wong Jimmy Ka Ming, Lai Choon-Sheen, Sun Lu-Zhe, Anti-Tumor Action, Clinical Biochemistry Profile and Phytochemical Constituents of a Pharmacologically Active Fraction of S. crispus in NMU-Induced Rat Mammary Tumour Model, PLOS ONE, 10, 5, 2015. Crossref

  7. Alvarado Antonieta, Gil da Costa Rui M., Faustino-Rocha Ana I., Ferreira Rita, Lopes Carlos, Oliveira Paula A., Colaço Bruno, Effects of exercise training on breast cancer metastasis in a rat model, International Journal of Experimental Pathology, 98, 1, 2017. Crossref

  8. Gutiérrez Alicia, Sambuco Lorena, Álvarez Laura, Núñez Mariel, Bergoc Rosa, Zotta Elsa, Martín Gabriela, Randi Andrea, Expression of estrogen receptor α variants and c-Fos in rat mammary gland and tumors, The Journal of Steroid Biochemistry and Molecular Biology, 199, 2020. Crossref

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