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Home Journals Critical Reviews™ in Immunology Volume 32, 2012 Issue 1 Functions of Fascin in Dendritic Cells
Critical Reviews™ in Immunology

ISSN Print: 1040-8401

ISSN Online: 2162-6472

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Functions of Fascin in Dendritic Cells

Volume 32, Issue 1, 2012, pp. 11-22
DOI: 10.1615/CritRevImmunol.v32.i1.20
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Shigeko Yamashiro
Department of Molecular Biology and Biochemistry, Nelson Labs, Rutgers University

ABSTRACT

Fascin-1 is an actin-bundling protein that shares no homology with other actin-bundling proteins. It is greatly induced upon maturation of dendritic cells (DCs). However, fascin-1 is not expressed in other primary blood cells, including macrophages and neutrophils, indicating a unique role of fascin-1 in the function of DCs upon maturation. An increasing body of evidence has shown that fascin-1 plays critical roles in maturation-associated DC functions, including dynamic assembly of veil-like membrane protrusions, disassembly of podosomes, migration to lymph nodes, and the assembly of the immunological synapse. Pathological analyses of fascin-1 expression revealed that fascin-1 is a useful marker of diseases of immune cells, including Langerhans cell histiocytosis and Hodgkin diseases. Furthermore, attempts have been made to explore the use of a fascin-1 promoter for DNA vaccination because it is strong and specific to DCs.

KEY WORDS: dendritic cells, fascin, migration, podosomes, immunological synapse
CITED BY

  1. Ma Yafeng, Machesky Laura M., Fascin1 in carcinomas: Its regulation and prognostic value, International Journal of Cancer, 137, 11, 2015. Crossref

  2. Goitia Veronica, Oquendo Marcial, Stratton Robert, Case of 7p22.1 Microduplication Detected by Whole Genome Microarray (REVEAL) in Workup of Child Diagnosed with Autism, Case Reports in Genetics, 2015, 2015. Crossref

  3. Ramos-Vara José A., Borst Luke B., Immunohistochemistry, in Tumors in Domestic Animals, 2016. Crossref

  4. Le Texier Laëtitia, Durand Justine, Lavault Amélie, Hulin Philippe, Collin Olivier, Le Bras Yvan, Cuturi Maria-Cristina, Chiffoleau Elise, Appel Silke, LIMLE, a New Molecule Over-Expressed following Activation, Is Involved in the Stimulatory Properties of Dendritic Cells, PLoS ONE, 9, 4, 2014. Crossref

  5. Rai Vikrant, Rao Velidi H., Shao Zhifei, Agrawal Devendra K., Chu Hong Wei, Dendritic Cells Expressing Triggering Receptor Expressed on Myeloid Cells-1 Correlate with Plaque Stability in Symptomatic and Asymptomatic Patients with Carotid Stenosis, PLOS ONE, 11, 5, 2016. Crossref

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  7. Yamashiro Shigeko, Matsumura Fumio, Fascin, in Encyclopedia of Signaling Molecules, 2016. Crossref

  8. Yamashiro Shigeko, Matsumura Fumio, Fascin, in Encyclopedia of Signaling Molecules, 2018. Crossref

  9. Hobernik Dominika, Bros Matthias, DNA Vaccines—How Far From Clinical Use?, International Journal of Molecular Sciences, 19, 11, 2018. Crossref

  10. Adzigbli Linda, Wang Ziman, Li Junhui, Deng Yuewen, Survival, retention rate and immunity of the black shell colored stocks of pearl oyster Pinctada fucata martensii after grafting operation, Fish & Shellfish Immunology, 98, 2020. Crossref

  11. Ronchese Franca, Hilligan Kerry L, Mayer Johannes U, Dendritic cells and the skin environment, Current Opinion in Immunology, 64, 2020. Crossref

  12. Sudowe Stephan, Höhn Yvonne, Renzing Andrea, Maxeiner Joachim, Montermann Evelyn, Habermeier Alice, Closs Ellen, Bros Matthias, Reske-Kunz Angelika B., Inhibition of antigen-specific immune responses by co-application of an indoleamine 2,3-dioxygenase (IDO)-encoding vector requires antigen transgene expression focused on dendritic cells, Amino Acids, 52, 3, 2020. Crossref

  13. Blumenthal Daniel, Chandra Vidhi, Avery Lyndsay, Burkhardt Janis K, Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex, eLife, 9, 2020. Crossref

  14. Auray Gaël, Talker Stephanie C., Keller Irene, Python Sylvie, Gerber Markus, Liniger Matthias, Ganges Llilianne, Bruggmann Rémy, Ruggli Nicolas, Summerfield Artur, High-Resolution Profiling of Innate Immune Responses by Porcine Dendritic Cell Subsets in vitro and in vivo, Frontiers in Immunology, 11, 2020. Crossref

  15. Rodríguez-Fernández José Luis, Criado-García Olga, The Actin Cytoskeleton at the Immunological Synapse of Dendritic Cells, Frontiers in Cell and Developmental Biology, 9, 2021. Crossref

  16. Matsumura Fumio, Polz Robin, Singh Sukhwinder, Matsumura Aya, Scheller Jürgen, Yamashiro Shigeko, Investigation of Fascin1, a Marker of Mature Dendritic Cells, Reveals a New Role for IL-6 Signaling in CCR7-Mediated Chemotaxis, The Journal of Immunology, 207, 3, 2021. Crossref

  17. Kim Hye-Ran, Park Jeong-Su, Park Jin-Hwa, Yasmin Fatima, Kim Chang-Hyun, Oh Se Kyu, Chung Ik-Joo, Jun Chang-Duk, Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy, Journal of Hematology & Oncology, 14, 1, 2021. Crossref

  18. Wang Yufeng, Song Mei, Liu Ming, Zhang Guoan, Zhang Xian, Li Ming O., Ma Xiaojing, Zhang J. Jillian, Huang Xin-Yun, Fascin inhibitor increases intratumoral dendritic cell activation and anti-cancer immunity, Cell Reports, 35, 1, 2021. Crossref

  19. Ku Min-Chi, Edes Inan, Bendix Ivo, Pohlmann Andreas, Waiczies Helmar, Prozorovski Tim, Günther Martin, Martin Conrad, Pagès Gilles, Wolf Susanne A., Kettenmann Helmut, Uckert Wolfgang, Niendorf Thoralf, Waiczies Sonia, ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas, Molecular Cancer Therapeutics, 15, 8, 2016. Crossref

  20. Kirkling Margaret E., Cytlak Urszula, Lau Colleen M., Lewis Kanako L., Resteu Anastasia, Khodadadi-Jamayran Alireza, Siebel Christian W., Salmon Hélène, Merad Miriam, Tsirigos Aristotelis, Collin Matthew, Bigley Venetia, Reizis Boris, Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells, Cell Reports, 23, 12, 2018. Crossref

  21. Alam Jehan, Yazdanpanah Ghasem, Ratnapriya Rinki, Borcherding Nicholas, de Paiva Cintia S., Li DeQuan, Pflugfelder Stephen C., Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes, Mucosal Immunology, 15, 4, 2022. Crossref

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