Critical Reviews™ in Immunology
ISSN Print: 1040-8401
ISSN Online: 2162-6472
IF:
2.214
5-Year IF:
3.347
SJR:
0.997
SNIP:
0.55
CiteScore™:
3.6
SLE-Associated Defects Promote Altered T Cell Function
pages 39-58
DOI: 10.1615/CritRevImmunol.2018025213
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ABSTRACT
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease linked to profound defects in the function and phenotype of T lymphocytes. Here, we describe abnormal signaling pathways that have been documented in T cells from patients with SLE and discuss how they impact gene expression and immune function, in order to understand how they contribute to disease development and progression.