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Critical Reviews™ in Therapeutic Drug Carrier Systems

Published 6 issues per year

ISSN Print: 0743-4863

ISSN Online: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

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Self-Emulsifying Drug Delivery Systems (SEDDS): Formulation Development, Characterization, and Applications

Volume 26, Issue 5, 2009, pp. 427-451
DOI: 10.1615/CritRevTherDrugCarrierSyst.v26.i5.10
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ABSTRACT

Self-emulsifying drug delivery systems (SEDDS) possess unparalleled potential in improving oral bioavailability of poorly water-soluble drugs. Following their oral administration, these systems rapidly disperse in gastrointestinal fluids, yielding micro- or nanoemulsions containing the solubilized drug. Owing to its miniscule globule size, the micro/nanoemulsifed drug can easily be absorbed through lymphatic pathways, bypassing the hepatic first-pass effect. We present an exhaustive and updated account of numerous literature reports and patents on diverse types of self-emulsifying drug formulations, with emphasis on their formulation, characterization, and systematic optimization strategies. Recent advancements in various methodologies employed to characterize their globule size and shape, ability to encapsulate the drug, gastrointestinal and thermodynamic stability, rheological characteristics, and so forth, are discussed comprehensively to guide the formula-tor in preparing an effective and robust SEDDS formulation. Also, this exhaustive review offers an explicit discussion on vital applications of the SEDDS in bioavailability enhancement of various drugs, outlining an overview on myriad in vitro, in situ, and ex vivo techniques to assess the absorption and/ or permeation potential of drugs incorporated in the SEDDS in animal and cell line models, and the subsequent absorption pathways followed by them. In short, the current article furnishes an updated compilation of wide-ranging information on all the requisite vistas of the self-emulsifying formulations, thus paving the way for accelerated progress into the SEDDS application in pharmaceutical research.

CITED BY
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  2. Khan Abdul Wadood, Kotta Sabna, Ansari Shahid H, Sharma Rakesh Kumar, Ali Javed, Potentials and challenges in self-nanoemulsifying drug delivery systems, Expert Opinion on Drug Delivery, 9, 10, 2012. Crossref

  3. Rahman Md. Akhlaquer, Hussain Arshad, Hussain Md. Sarfaraj, Mirza Mohd. Aamir, Iqbal Zeenat, Role of excipients in successful development of self-emulsifying/microemulsifying drug delivery system (SEDDS/SMEDDS), Drug Development and Industrial Pharmacy, 39, 1, 2013. Crossref

  4. Singh Bhupinder, Singh Ramandeep, Bandyopadhyay Shantanu, Kapil Rishi, Garg Babita, Optimized nanoemulsifying systems with enhanced bioavailability of carvedilol, Colloids and Surfaces B: Biointerfaces, 101, 2013. Crossref

  5. Beg Sarwar, Jena Sidharth Sankar, Patra Ch Niranjan, Rizwan Mohammad, Swain Suryakanta, Sruti J., Rao M.E. Bhanoji, Singh Bhupinder, Development of solid self-nanoemulsifying granules (SSNEGs) of ondansetron hydrochloride with enhanced bioavailability potential, Colloids and Surfaces B: Biointerfaces, 101, 2013. Crossref

  6. Mu Huiling, Holm René, Müllertz Anette, Lipid-based formulations for oral administration of poorly water-soluble drugs, International Journal of Pharmaceutics, 453, 1, 2013. Crossref

  7. Shao Ali, Chen Gang, Jiang Nan, Li Ye, Zhang Xiao, Wen Lu, Yang Fan, Wei Shaoyang, Development and evaluation of self-microemulsifying liquid and granule formulations of Brucea javanica oil, Archives of Pharmacal Research, 36, 8, 2013. Crossref

  8. Badran Mohamed M., Taha Ehab I., Tayel Moustafa M., Al-Suwayeh Saleh A., Ultra-fine self nanoemulsifying drug delivery system for transdermal delivery of meloxicam: Dependency on the type of surfactants, Journal of Molecular Liquids, 190, 2014. Crossref

  9. Wang Shu, Su Rui, Nie Shufang, Sun Ming, Zhang Jia, Wu Dayong, Moustaid-Moussa Naima, Application of nanotechnology in improving bioavailability and bioactivity of diet-derived phytochemicals, The Journal of Nutritional Biochemistry, 25, 4, 2014. Crossref

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  41. Tripathi Chandra Bhushan, Beg Sarwar, Kaur Ripandeep, Shukla Geeta, Bandopadhyay Shantanu, Singh Bhupinder, Systematic development of optimized SNEDDS of artemether with improved biopharmaceutical and antimalarial potential, Drug Delivery, 23, 9, 2016. Crossref

  42. Parakh Durgesh Rameshlal, Patil Moreshwar Pandharinath, Sonawane Sandeep Suresh, Kshirsagar Sanjay Jayprakash, Application of factorial design approach in development and evaluation of self microemulsifying drug delivery system (SMEDDS) of mebendazole, Journal of Pharmaceutical Investigation, 47, 6, 2017. Crossref

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  93. Bindhani Sabitri, Mohapatra S., Kar R.K., Self Emulsifying Drug Delivery System: A Recent Approach, Asian Journal of Chemistry, 31, 4, 2019. Crossref

  94. Lodaya Rushit N., Kanitkar Amey P., Friedrich Kristian, Henson Dawn, Yamagata Ryan, Nuti Sandra, Mallett Corey P., Bertholet Sylvie, Amiji Mansoor M., O’Hagan Derek T., Formulation Design, Optimization and In Vivo Evaluations of an α-Tocopherol-Containing Self-Emulsified Adjuvant System using Inactivated Influenza Vaccine, Journal of Controlled Release, 316, 2019. Crossref

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  114. Pandey Narendra Kumar, Singh Sachin Kumar, Gulati Monica, Kumar Bimlesh, Kapoor Bhupinder, Ghosh Dipanjoy, Kumar Rajan, Khursheed Rubiya, Awasthi Ankit, Kuppusamy Gowthamarajan, Wadhwa Sheetu, Satija Saurabh, Dureja Harish, Jain Subheet Kumar, Chellappan Dinesh Kumar, Anand Krishnan, Mehta Meenu, Dua Kamal, Overcoming the dissolution rate, gastrointestinal permeability and oral bioavailability of glimepiride and simvastatin co-delivered in the form of nanosuspension and solid self-nanoemulsifying drug delivery system: A comparative study, Journal of Drug Delivery Science and Technology, 60, 2020. Crossref

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  130. Monton Chaowalit, Chankana Natawat, Leelawat Surang, Suksaeree Jirapornchai, Songsak Thanapat, Optimization of supercritical carbon dioxide fluid extraction of seized cannabis and self-emulsifying drug delivery system for enhancing the dissolution of cannabis extract, The Journal of Supercritical Fluids, 179, 2022. Crossref

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  139. G. Raut Vrushali, P. Chaudhari Bharatee, K. Redasani Vivekkumar, Influence of Newly Synthesized Superdisintegrant on Dissolution Rate Enhancement of Carbamazepine using Liquisolid Compact Technique, Asian Journal of Research in Pharmaceutical Sciences, 2022. Crossref

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  143. Ogino Mizuki, Nakazawa Asuka, Shiokawa Ken-ichi, Kikuchi Hiroshi, Sato Hideyuki, Onoue Satomi, Krill oil-based self-emulsifying drug delivery system to improve oral absorption and renoprotective function of ginger extract, PharmaNutrition, 19, 2022. Crossref

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  147. Ahmad Niyaz, Ahmad Rizwan, Al-Qudaihi Ali, Alaseel Salman Edrees, Fita Ibrahim Zuhair, Khalid Mohammed Saifuddin, Pottoo Faheem Hyder, Bolla Srinivasa Rao, RETRACTED ARTICLE: A novel self-nanoemulsifying drug delivery system for curcumin used in the treatment of wound healing and inflammation, 3 Biotech, 9, 10, 2019. Crossref

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  154. Onoue Satomi, Uchida Atushi, Kuriyama Kazuki, Nakamura Tatsuya, Seto Yoshiki, Kato Masashi, Hatanaka Junya, Tanaka Toshiyuki, Miyoshi Hiroyuki, Yamada Shizuo, Novel solid self-emulsifying drug delivery system of coenzyme Q10 with improved photochemical and pharmacokinetic behaviors, European Journal of Pharmaceutical Sciences, 46, 5, 2012. Crossref

  155. Lohan Shikha, Sharma Teenu, Saini Sumant, Singh Arti, Kumar Anil, Raza Kaisar, Kaur Jalseen, Singh Bhupinder, Galactosylated nanoconstructs of Berberine with enhanced Biopharmaceutical and cognitive potential: A preclinical evidence in Alzheimer ‘s disease, Journal of Drug Delivery Science and Technology, 66, 2021. Crossref

  156. Giarra Simona, Lupo Noemi, Campani Virginia, Carotenuto Alfonso, Mayol Laura, De Rosa Giuseppe, Bernkop-Schnürch Andreas, In vitro evaluation of tumor targeting ability of a parenteral enoxaparin-coated self-emulsifying drug delivery system, Journal of Drug Delivery Science and Technology, 53, 2019. Crossref

  157. Meirinho Sara, Rodrigues Márcio, Santos Adriana O., Falcão Amílcar, Alves Gilberto, Self-Emulsifying Drug Delivery Systems: An Alternative Approach to Improve Brain Bioavailability of Poorly Water-Soluble Drugs through Intranasal Administration, Pharmaceutics, 14, 7, 2022. Crossref

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  159. Nagarsheth Aishwarya, Patel Darshana, Thakkar Hetal, Formulation and evaluation of proliposomal tablet of Diclofenac sodium, Journal of Drug Delivery Science and Technology, 71, 2022. Crossref

  160. Mo Liuying, Zhang Fan, Chen Feng, Xia Lei, Huang Yi, Mo Yuemi, Zhang Lingqiu, Huang Daquan, He Shunli, Deng Jiagang, Hao Erwei, Du Zhengcai, Progress on structural modification of Tetrandrine with wide range of pharmacological activities, Frontiers in Pharmacology, 13, 2022. Crossref

  161. Chhitij Thapa, Seo Jo-Eun, Keum Taekwang, Noh Gyubin, Bashyal Santosh, Lamichhane Shrawani, Kim Jung Hwan, Lee Jae Heon, Park Jee Hun, Choi Jaewoong, Song Se Hyun, Lee Sangkil, Optimized self-microemulsifying drug delivery system improves the oral bioavailability and brain delivery of coenzyme Q10, Drug Delivery, 29, 1, 2022. Crossref

  162. Niu Xia, Meng Yanan, Wang Yucheng, Li Guiling, Established new compound IMB16-4 self-emulsifying drug delivery systems for increasing oral bioavailability and enhancing anti-hepatic fibrosis effect, Biomedicine & Pharmacotherapy, 154, 2022. Crossref

  163. Vishwas Sukriti, Gulati Monica, Khursheed Rubiya, Arya K.R., Singh Sachin Kumar, Jha Niraj Kumar, Prasher Parteek, Kumar Deepak, Kumar Vijay, Advanced drug delivery systems to treat Huntington’s disease: challenges and opportunities, in Drug Delivery Systems for Metabolic Disorders, 2022. Crossref

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