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Critical Reviews™ in Therapeutic Drug Carrier Systems

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ISSN Print: 0743-4863

ISSN Online: 2162-660X

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.7 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 3.6 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.8 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00023 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.39 SJR: 0.42 SNIP: 0.89 CiteScore™:: 5.5 H-Index: 79

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The Role of Polymers and Excipients for Better Gastric Retention of Captopril

Volume 39, Issue 6, 2022, pp. 85-106
DOI: 10.1615/CritRevTherDrugCarrierSyst.2022042122
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ABSTRACT

Captopril is an angiotensin-converting enzyme (ACE) inhibitor that prevents angiotensin I (ATI) from being converted to angiotensin II (ATII). However, it offers certain limitations like instability, dose dumping and burst release due to its usage in the native state. In the last two decades, different polymers and excipients have been used to make captopril more accessible and well-accepted. The present work discusses the efforts made by various scientists so far to make the oral administration of captopril more acceptable by overcoming its limitations. The different factors affecting gastric retention, approaches to achieve better gastric retention. The oral managed release dosage forms have enormous curative benefits such as improved therapeutics and better patient compliance. The polymer based gastro-retentive drug delivery systems (GRDDS) include microspheres, soild inclusion complex, floating tablets, alginate based beads, etc utilizes better retention in the stomach for longer duration of action and improved bioavailability. Overall, the work aims to summarize the attempts made as novel drug delivery approaches over the last two decades in reverse chronological order to make captopril more gastro retentive and orally acceptable by the patients.

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