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Critical Reviews™ in Oncogenesis

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RUNX1 Mutations in Clonal Myeloid Disorders: From Conventional Cytogenetics to Next Generation Sequencing, A Story 40 Years in the Making

Volume 16, Issue 1-2, 2011, pp. 77-91
DOI: 10.1615/CritRevOncog.v16.i1-2.80
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James K. Mangan
Department of Internal Medicine, Division of Hematology-Oncology and the Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania
Nancy A. Speck
Abramson Family Cancer Research Institute and Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

ABSTRACT

Translocations and mutations in the core binding factor genes, RUNX1 or CBFB, are found in acute myeloid and lymphocytic leukemia, therapy-related myeloid leukemia, myelodysplastic syndrome, chronic myelomonocytic leukemia, and in familial platelet disorder with predisposition to acute myeloid leukemia. Here we review the biochemical and biological properties of the normal Runx1 protein, discuss the nature of RUNX1 mutations in myeloid leukemia, their prognostic significance, and the mutations that cooperate or co-exist with them in these various diseases.

KEY WORDS: Runx1, AML, MDS, hematopoietic stem cells.
CITED BY

  1. Zhang Yue, Yan Xiaomei, Sashida Goro, Zhao Xinghui, Rao Yalan, Goyama Susumu, Whitman Susan P., Zorko Nicholas, Bernot Kelsie, Conway Rajeana M., Witte David, Wang Qian-fei, Tenen Daniel G., Xiao Zhijian, Marcucci Guido, Mulloy James C., Grimes H. Leighton, Caligiuri Michael A., Huang Gang, Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells, Blood, 120, 5, 2012. Crossref

  2. Scheitz Cornelia Johanna Franziska, Lee Tae Seung, McDermitt David James, Tumbar Tudorita, Defining a tissue stem cell-driven Runx1/Stat3 signalling axis in epithelial cancer, The EMBO Journal, 31, 21, 2012. Crossref

  3. Chuang Linda Shyue Huey, Ito Kosei, Ito Yoshiaki, RUNX family: Regulation and diversification of roles through interacting proteins, International Journal of Cancer, 132, 6, 2013. Crossref

  4. Scheitz Cornelia Johanna Franziska, Tumbar Tudorita, New insights into the role of Runx1 in epithelial stem cell biology and pathology, Journal of Cellular Biochemistry, 114, 5, 2013. Crossref

  5. Avci C. B., Dodurga Y., Susluer S. Y., Sıgva Z. O. D., Yucebas M., Caglar H. O., Akalin T., Dalbasti T., Oktar N., Gunduz C., Promoter hypermethylation-mediated down-regulation of RUNX3 gene in human brain tumors, Irish Journal of Medical Science, 183, 2, 2014. Crossref

  6. Wilkinson Adam C., Ballabio Erica, Geng Huimin, North Phillip, Tapia Marta, Kerry Jon, Biswas Debabrata, Roeder Robert G., Allis C. David, Melnick Ari, de Bruijn Marella F.T.R., Milne Thomas A., RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction, Cell Reports, 3, 1, 2013. Crossref

  7. Real Pedro J., Navarro-Montero Oscar, Ramos-Mejía Verónica, Ayllón Verónica, Bueno Clara, Menéndez Pablo, The role of RUNX1 isoforms in hematopoietic commitment of human pluripotent stem cells, Blood, 121, 26, 2013. Crossref

  8. Bresciani Erica, Carrington Blake, Wincovitch Stephen, Jones MaryPat, Gore Aniket V., Weinstein Brant M., Sood Raman, Liu P. Paul, CBFβ and RUNX1 are required at 2 different steps during the development of hematopoietic stem cells in zebrafish, Blood, 124, 1, 2014. Crossref

  9. Rossetti Stefano, Sacchi Nicoletta, RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis, International Journal of Molecular Sciences, 14, 1, 2013. Crossref

  10. Liu T, Altman RB, Identifying Druggable Targets by Protein Microenvironments Matching: Application to Transcription Factors, CPT: Pharmacometrics & Systems Pharmacology, 3, 1, 2014. Crossref

  11. Sood Raman, Liu Paul, Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models, Advances in Hematology, 2012, 2012. Crossref

  12. Kim Myungshin, Kim Jiyeon, Kim Jung Rok, Han Eunhee, Park Joonhong, Lim Jihyang, Kim Yonggoo, Han Kyungja, Kim Hee-Je, Min Woo-Sung, Cho Bin, FLT3 expression and IL10 promoter polymorphism in acute myeloid leukemia with RUNX1-RUNX1T1, Molecular Biology Reports, 42, 2, 2015. Crossref

  13. Ozaki Toshinori, Nakamura Mizuyo, Shimozato Osamu, Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2, Biomolecules, 5, 4, 2015. Crossref

  14. Ito Yoshiaki, Bae Suk-Chul, Chuang Linda Shyue Huey, The RUNX family: developmental regulators in cancer, Nature Reviews Cancer, 15, 2, 2015. Crossref

  15. Hirade Tomohiro, Abe Mariko, Onishi Chie, Taketani Takeshi, Yamaguchi Seiji, Fukuda Seiji, Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells, International Journal of Hematology, 103, 1, 2016. Crossref

  16. Cai Xiongwei, Gao Long, Teng Li, Ge Jingping, Oo Zaw Min, Kumar Ashish R., Gilliland D. Gary, Mason Philip J., Tan Kai, Speck Nancy A., Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells, Cell Stem Cell, 17, 2, 2015. Crossref

  17. Fiedler Marc, Graeb Michael, Mieszczanek Juliusz, Rutherford Trevor J, Johnson Christopher M, Bienz Mariann, An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP, eLife, 4, 2015. Crossref

  18. Imperato Maria Rosaria, Cauchy Pierre, Obier Nadine, Bonifer Constanze, The RUNX1–PU.1 axis in the control of hematopoiesis, International Journal of Hematology, 101, 4, 2015. Crossref

  19. Orsolic Ines, Jurada Deana, Pullen Nick, Oren Moshe, Eliopoulos Aristides G., Volarevic Sinisa, The relationship between the nucleolus and cancer: Current evidence and emerging paradigms, Seminars in Cancer Biology, 37-38, 2016. Crossref

  20. Tober J., Maijenburg M.W., Speck N.A., Taking the Leap, in Hematopoiesis, 118, 2016. Crossref

  21. Daly Martina E., Transcription factor defects causing platelet disorders, Blood Reviews, 31, 1, 2017. Crossref

  22. Martinez Milka, Hinojosa Marcela, Trombly Daniel, Morin Violeta, Stein Janet, Stein Gary, Javed Amjad, Gutierrez Soraya E., van Wijnen Andre, Transcriptional Auto-Regulation of RUNX1 P1 Promoter, PLOS ONE, 11, 2, 2016. Crossref

  23. Nardi Valentina, Hasserjian Robert P., Genetic Testing in Acute Myeloid Leukemia and Myelodysplastic Syndromes, Surgical Pathology Clinics, 9, 1, 2016. Crossref

  24. You Eunkyoung, Cho Young-Uk, Jang Seongsoo, Seo Eul-Ju, Lee Jung-Hee, Lee Je-Hwan, Lee Kyoo-Hyung, Koh Kyung-Nam, Im Ho Joon, Seo Jong Jin, Park Young-Mi, Lee Jong-Keuk, Park Chan-Jeoung, Frequency and Clinicopathologic Features of RUNX1 Mutations in Patients With Acute Myeloid Leukemia Not Otherwise Specified, American Journal of Clinical Pathology, 148, 1, 2017. Crossref

  25. Oo Zaw Min, Illendula Anuradha, Grembecka Jolanta, Schmidt Charles, Zhou Yunpeng, Esain Virginie, Kwan Wanda, Frost Isaura, North Trista E., Rajewski Roger A., Speck Nancy A., Bushweller John H., A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells, Leukemia & Lymphoma, 59, 9, 2018. Crossref

  26. Chimge Nyam-Osor, Ahmed-Alnassar Sara, Frenkel Baruch, Relationship between RUNX1 and AXIN1 in ER-negative versus ER-positive Breast Cancer, Cell Cycle, 16, 4, 2017. Crossref

  27. Bellissimo Dana C., Speck Nancy A., RUNX1 Mutations in Inherited and Sporadic Leukemia, Frontiers in Cell and Developmental Biology, 5, 2017. Crossref

  28. Tahirov Tahir H., Bushweller John, Structure and Biophysics of CBFβ/RUNX and Its Translocation Products, in RUNX Proteins in Development and Cancer, 962, 2017. Crossref

  29. Robetorye Ryan S., Acute Myeloid Leukemia with Recurrent Genetic Abnormalities, Part II: Mutations Involving CEBPA, NPM1, and RUNX1, in Precision Molecular Pathology of Myeloid Neoplasms, 12, 2018. Crossref

  30. Cavalcante de Andrade Silva Marcela, Krepischi Ana Cristina Victorino, Kulikowski Leslie Domenici, Zanardo Evelin Aline, Nardinelli Luciana, Leal Aline Medeiros, Costa Silvia Souza, Muto Nair Hideki, Rocha Vanderson, Velloso Elvira Deolinda Rodrigues Pereira, Deletion of RUNX1 exons 1 and 2 associated with familial platelet disorder with propensity to acute myeloid leukemia, Cancer Genetics, 222-223, 2018. Crossref

  31. Sarper Safiye E., Inubushi Toshihiro, Kurosaka Hiroshi, Ono Minagi Hitomi, Kuremoto Koh-ichi, Sakai Takayoshi, Taniuchi Ichiro, Yamashiro Takashi, Runx1-Stat3 signaling regulates the epithelial stem cells in continuously growing incisors, Scientific Reports, 8, 1, 2018. Crossref

  32. Fukuda Seiji, Hirade Tomohiro, Abe Mariko, Taketani Takeshi, Onishi Chie, Molecular Interaction Between the Microenvironment and FLT3/ITD+ AML Cells Leading to the Refractory Phenotype, in Myeloid Leukemia, 2018. Crossref

  33. Mill Christopher P., Fiskus Warren, DiNardo Courtney D., Qian Yimin, Raina Kanak, Rajapakshe Kimal, Perera Dimuthu, Coarfa Cristian, Kadia Tapan M., Khoury Joseph D., Saenz Dyana T., Saenz David N., Illendula Anuradha, Takahashi Koichi, Kornblau Steven M., Green Michael R., Futreal Andrew P., Bushweller John H., Crews Craig M., Bhalla Kapil N., RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1, Blood, 134, 1, 2019. Crossref

  34. Chokr Nora, Pine Alexander B., Bewersdorf Jan Philipp, Shallis Rory M., Stahl Maximilian, Zeidan Amer M., Getting personal with myelodysplastic syndromes: is now the right time?, Expert Review of Hematology, 12, 4, 2019. Crossref

  35. Chisholm Karen M, Denton Christopher, Keel Sioban, Geddis Amy E, Xu Min, Appel Burton E, Cantor Alan B, Fleming Mark D, Shimamura Akiko, Bone Marrow Morphology Associated With GermlineRUNX1Mutations in Patients With Familial Platelet Disorder With Associated Myeloid Malignancy, Pediatric and Developmental Pathology, 22, 4, 2019. Crossref

  36. Branford Susan, Kim Dennis Dong Hwan, Apperley Jane F., Eide Christopher A., Mustjoki Satu, Ong S. Tiong, Nteliopoulos Georgios, Ernst Thomas, Chuah Charles, Gambacorti-Passerini Carlo, Mauro Michael J., Druker Brian J., Kim Dong-Wook, Mahon Francois-Xavier, Cortes Jorge, Radich Jerry P., Hochhaus Andreas, Hughes Timothy P., Laying the foundation for genomically-based risk assessment in chronic myeloid leukemia, Leukemia, 33, 8, 2019. Crossref

  37. Rossetti Stefano, Anauo Michael J., Sacchi Nicoletta, MiR-221-regulated KIT level by wild type or leukemia mutant RUNX1: a determinant of single myeloblast fate decisions that - collectively – drives or hinders granulopoiesis, Oncotarget, 8, 49, 2017. Crossref

  38. Bellissimo Dana C., Chen Chia-hui, Zhu Qin, Bagga Sumedha, Lee Chung-Tsai, He Bing, Wertheim Gerald B., Jordan Martha, Tan Kai, Worthen G. Scott, Gilliland D. Gary, Speck Nancy A., Runx1 negatively regulates inflammatory cytokine production by neutrophils in response to Toll-like receptor signaling, Blood Advances, 4, 6, 2020. Crossref

  39. Khateb Ali, Ronai Ze’ev A., Unfolded Protein Response in Leukemia: From Basic Understanding to Therapeutic Opportunities, Trends in Cancer, 6, 11, 2020. Crossref

  40. Nguyen Lynh, Zhang Xiaohui, Roberts Evans, Yun Seongseok, McGraw Kathy, Abraham Ivo, Song Jinming, Braswell Diana, Qin Dahui, Sallman David A., Lancet Jeffrey E., List Alan F., Moscinski Lynn C., Padron Eric, Zhang Ling, Comparison of mutational profiles and clinical outcomes in patients with acute myeloid leukemia with mutated RUNX1 versus acute myeloid leukemia with myelodysplasia-related changes with mutated RUNX1, Leukemia & Lymphoma, 61, 6, 2020. Crossref

  41. Olkhovskiy I.A., Komina A.V., Stolyar M.A., Gorbenko A.S., Molecular genetic disorders in acute leukemia as a basis for the development of diagnostic tests (literature review), Laboratornaya sluzhba, 9, 4, 2020. Crossref

  42. Yang Xin, Wang Shumei, Reheman Alimu, <p>Regulation of <em>RUNX3</em> Expression by DNA Methylation in Prostate Cancer</p>, Cancer Management and Research, Volume 12, 2020. Crossref

  43. Fischer John Adams, Rossetti Stefano, Datta Arani, Eng Kevin Hasegawa, Beghini Alessandro, Sacchi Nicoletta, miR-17 deregulates a core RUNX1-miRNA mechanism of CBF acute myeloid leukemia, Molecular Cancer, 14, 1, 2015. Crossref

  44. Huang Zhibin, Chen Kemin, Chi Yali, Jin Hao, Li Li, Zhang Wenqing, Xu Jin, Zhang Yiyue, Runx1 regulates zebrafish neutrophil maturation via synergistic interaction with c-Myb, Journal of Biological Chemistry, 296, 2021. Crossref

  45. Gonzales Fanny, Barthélémy Adeline, Peyrouze Pauline, Fenwarth Laurène, Preudhomme Claude, Duployez Nicolas, Cheok Meyling H., Targeting RUNX1 in acute myeloid leukemia: preclinical innovations and therapeutic implications, Expert Opinion on Therapeutic Targets, 25, 4, 2021. Crossref

  46. Savage Sharon A., McReynolds Lisa J., Niewisch Marena R., Altintas Burak, Gianferante D. Matthew, Alter Blanche P., Cancer-Prone Inherited Bone Marrow Failure, Myelodysplastic, and Acute Myeloid Leukemia Syndromes, in The Hereditary Basis of Childhood Cancer, 2021. Crossref

  47. Vagher Jennie, Maese Luke, Gammon Amanda, Kohlmann Wendy, Schiffman Joshua D., Inherited Risk for Childhood Leukemia, in The Hereditary Basis of Childhood Cancer, 2021. Crossref

  48. McDonald Laura, Ferrari Nicola, Terry Anne, Bell Margaret, Mohammed Zahra M., Orange Clare, Jenkins Alma, Muller William J., Gusterson Barry A., Neil James C., Edwards Joanne, Morris Joanna S., Cameron Ewan R., Blyth Karen, RUNX2 in subtype specific breast cancer and mammary gland differentiation, Disease Models & Mechanisms, 2014. Crossref

  49. Jarzebowski Léonard, Le Bouteiller Marie, Coqueran Sabrina, Raveux Aurélien, Vandormael-Pournin Sandrine, David Alexandre, Cumano Ana, Cohen-Tannoudji Michel, Mouse adult hematopoietic stem cells actively synthesize ribosomal RNA, RNA, 24, 12, 2018. Crossref

  50. Neel Benjamin G., Speck Nancy A., Tyrosyl phosphorylation toggles a Runx1 switch, Genes & Development, 26, 14, 2012. Crossref

  51. Tober Joanna, Yzaguirre Amanda D., Piwarzyk Eileen, Speck Nancy A., Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells, Development, 140, 18, 2013. Crossref

  52. Aoyagi Yasushige, Hayashi Yoshihiro, Harada Yuka, Choi Kwangmin, Matsunuma Natsumi, Sadato Daichi, Maemoto Yuki, Ito Akihiro, Yanagi Shigeru, Starczynowski Daniel T., Harada Hironori, Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes, Cancer Discovery, 12, 1, 2022. Crossref

  53. Chimge N-O, Frenkel B, The RUNX family in breast cancer: relationships with estrogen signaling, Oncogene, 32, 17, 2013. Crossref

  54. Illango Janan, Sreekantan Nair Archana, Gor Rajvi, Wijeratne Fernando Ransirini, Malik Mushrin, Siddiqui Nabeel A, Hamid Pousette, A Systematic Review of the Role of Runt-Related Transcription Factor 1 (RUNX1) in the Pathogenesis of Hematological Malignancies in Patients With Inherited Bone Marrow Failure Syndromes, Cureus, 2022. Crossref

  55. Mill Christopher P., Fiskus Warren, DiNardo Courtney D., Birdwell Christine, Davis John A., Kadia Tapan M., Takahashi Koichi, Short Nicholas, Daver Naval, Ohanian Maro, Borthakur Gautam, Kornblau Steven M., Green Michael R., Qi Yuan, Su Xiaoping, Khoury Joseph D., Bhalla Kapil N., Effective therapy for AML with RUNX1 mutation by cotreatment with inhibitors of protein translation and BCL2, Blood, 139, 6, 2022. Crossref

  56. Simon Laura, Lavallée Vincent-Philippe, Bordeleau Marie-Eve, Krosl Jana, Baccelli Irène, Boucher Geneviève, Lehnertz Bernhard, Chagraoui Jalila, MacRae Tara, Ruel Réjean, Chantigny Yves, Lemieux Sébastien, Marinier Anne, Hébert Josée, Sauvageau Guy, Chemogenomic Landscape of RUNX1-mutated AML Reveals Importance of RUNX1 Allele Dosage in Genetics and Glucocorticoid Sensitivity, Clinical Cancer Research, 23, 22, 2017. Crossref

  57. Li Bin E., Ernst Patricia, Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia, Experimental Hematology, 42, 12, 2014. Crossref

  58. Ng Alvin Wei Tian, Contino Gianmarco, Killcoyne Sarah, Devonshire Ginny, Hsu Ray, Abbas Sujath, Su Jing, Redmond Aisling M., Weaver Jamie M. J., Eldridge Matthew D., Tavaré Simon, Grehan Nicola, Nutzinger Barbara, Fidziukiewicz Elwira, Freeman Adam, Smyth Elizabeth C., O’Donovan Maria, Miremadi Ahmad, Malhotra Shalini, Tripathi Monika, Cheah Calvin, Coles Hannah, Flint Connor, Eldridge Matthew, Secrier Maria, Jammula Sriganesh, Davies Jim, Crichton Charles, Carroll Nick, Hardwick Richard H., Safranek Peter, Hindmarsh Andrew, Sujendran Vijayendran, Hayes Stephen J., Ang Yeng, Sharrocks Andrew, Preston Shaun R., Bagwan Izhar, Save Vicki, Skipworth Richard J. E., Hupp Ted R., O’Neill J. Robert, Tucker Olga, Beggs Andrew, Taniere Philippe, Puig Sonia, Underwood Timothy J., Walker Robert C., Grace Ben L., Lagergren Jesper, Gossage James, Davies Andrew, Chang Fuju, Mahadeva Ula, Goh Vicky, Ciccarelli Francesca D., Sanders Grant, Berrisford Richard, Chan David, Cheong Ed, Kumar Bhaskar, Sreedharan L., Parsons Simon L., Soomro Irshad, Kaye Philip, Saunders John, Lovat Laurence, Haidry Rehan, Scott Michael, Sothi Sharmila, Lishman Suzy, Hanna George B., Peters Christopher J., Moorthy Krishna, Grabowska Anna, Turkington Richard, McManus Damian, Coleman Helen, Petty Russell D., Bartlett Freddie, Edwards Paul A. W., Fitzgerald Rebecca C., Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas, Communications Biology, 5, 1, 2022. Crossref

  59. Gaidzik V I, Teleanu V, Papaemmanuil E, Weber D, Paschka P, Hahn J, Wallrabenstein T, Kolbinger B, Köhne C H, Horst H A, Brossart P, Held G, Kündgen A, Ringhoffer M, Götze K, Rummel M, Gerstung M, Campbell P, Kraus J M, Kestler H A, Thol F, Heuser M, Schlegelberger B, Ganser A, Bullinger L, Schlenk R F, Döhner K, Döhner H, RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features, Leukemia, 30, 11, 2016. Crossref

  60. Fernandes Adelina, Shanmuganathan Naranie, Branford Susan, Genomic Mechanisms Influencing Outcome in Chronic Myeloid Leukemia, Cancers, 14, 3, 2022. Crossref

  61. Menter Thomas, Lundberg Pontus, Wenzel Friedel, Dirks Jan, Fernandez Paula, Friess Dorothea, Dirnhofer Stefan, Tzankov Alexandar, <b><i>RUNX1</i></b> Mutations Can Lead to Aberrant Expression of CD79a and PAX5 in Acute Myelogenous Leukemias: A Potential Diagnostic Pitfall, Pathobiology, 86, 2-3, 2019. Crossref

  62. Zhao Han, Chen Yun, Shen Peijun, Gong Lan, Prognostic value and immune characteristics of RUNX gene family in human cancers: a pan-cancer analysis, Aging, 14, 9, 2022. Crossref

  63. Kohlmann A, Nadarajah N, Alpermann T, Grossmann V, Schindela S, Dicker F, Roller A, Kern W, Haferlach C, Schnittger S, Haferlach T, Monitoring of residual disease by next-generation deep-sequencing of RUNX1 mutations can identify acute myeloid leukemia patients with resistant disease, Leukemia, 28, 1, 2014. Crossref

  64. Menezes Ana Catarina, Jones Rachel, Shrestha Alina, Nicholson Rachael, Leckenby Adam, Azevedo Aleksandra, Davies Sara, Baker Sarah, Gilkes Amanda F., Darley Richard L., Tonks Alex, Increased expression of RUNX3 inhibits normal human myeloid development, Leukemia, 36, 7, 2022. Crossref

  65. Akhila Raj TV, Gopinath Preethi, Geetha Raj JA, Narayanan Geetha, Nair SreejithG, Joy Philip DeepaSusan, Raveendran Suresh, Geetha Priya, Sreedharan Hariharan, Acute myeloid leukemia patients with variant or unusual translocations involving chromosomes 8 and 21 – A comprehensive cytogenetic profiling of three cases with review of literature, Journal of Cancer Research and Therapeutics, 18, 3, 2022. Crossref

  66. Rossmann Marlies P., Orkin Stuart H., Chute John P., Hematopoietic Stem Cell Biology, in Hematology, 2018. Crossref

  67. Venugopal Sangeetha, DiNardo Courtney D., Loghavi Sanam, Qiao Wei, Ravandi Farhad, Konopleva Marina, Kadia Tapan, Bhalla Kapil, Jabbour Elias, Issa Ghayas C., Macaron Walid, Daver Naval, Borthakur Gautam, Montalban‐Bravo Guillermo, Yilmaz Musa, Patel Keyur P., Kanagal‐Shamanna Rashmi, Chien Kelly, Maiti Abhishek, Kantarjian Hagop, Short Nicholas J., Differential prognostic impact of RUNX1 mutations according to frontline therapy in patients with acute myeloid leukemia , American Journal of Hematology, 2022. Crossref

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