The home for science and engineering™
English 中文 Русский Português German French Spain Prices and Subscription Policies Begell House Contact Us
Customer Login 0 Shopping Cart
Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Home Journals Critical Reviews™ in Eukaryotic Gene Expression Volume 29, 2019 Issue 4 Programming hMSCs into Potential Genetic Therapy in Cancer
Critical Reviews™ in Eukaryotic Gene Expression
Managing Editors: Lisa Vear Ariana Spatola

ISSN Print: 1045-4403

ISSN Online: 2162-6502

IF: 2.156 5-Year IF: 2.333 SJR: 0.649 SNIP: 0.599 CiteScore™: 3.1
Gain Access
More
Articles Back to issue Forthcoming Last issue Archives Purchase $35.00 Check subscription Download MARC record Get Permissions Add to Citation Manager Dowload the citation in the EndNote format Dowload the citation in the RefWorks format Dowload the citation in the BibTex format

Programming hMSCs into Potential Genetic Therapy in Cancer

pages 343-350
DOI: 10.1615/CritRevEukaryotGeneExpr.2019030483
Get accessGet access
Nedime Serakinci
Near East University, Faculty of Medicine, Department of Medical Genetics, Near East Avenue, Nicosia 99138, Northern Cyprus; Near East University, Faculty of Arts and Sciences, Dept. of Molecular Biology and Genetics, Near East Avenue, Nicosia 99138, Northern Cyprus
Huseyin Cagsin
Near East University, Faculty of Medicine, Department of Medical Genetics, Nicosia, Turkish Republic of Northern Cyprus; Near East University, Faculty of Art and Sciences, Department of Molecular Biology and Genetics, Nicosia, Turkish Republic of Northern Cyprus

ABSTRACT

Based on their distinct characteristics, such as self-renewal and differentiation potential, human mesenchymal stem cells (hMSCs) have been proposed as a feasible tool for cancer therapy. The characteristic of hMSCs that can be used in cancer therapy is their ability to home to primary and metastatic tumor sites. Recent studies have shown that use of stem cells obtained from adult tissue may be a novel vehicle for stem cell–mediated cancer therapy with improved antitumor effects. Stem cells have been used as vehicles to deliver various agents to tumor sites in order to decrease the size of the tumor or increase the lifespan of the organism. Genetically modified MSCs have been shown to increase apoptosis and decrease growth and angiogenesis in solid tumors. In this review, we will focus on the potential of the genetically modified hMSC-based genetic therapy that is a combination of stem cell and gene therapy approaches and its potential advantages over current therapies.

KEY WORDS: genetic therapy, MSC, hMSC, stem cell therapy, telomerase, telomere, differentiation, cancer, cancer therapy
REFERENCES

  1. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, Verfaillie CM. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature. 2002 Jul;418(6893):41-9.

  2. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016 Jan;66(1):7-30.

  3. Kortesidis A, Zannettino A, Isenmann S, Shi S, Lapidot T, Gronthos S. Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells. Blood. 2005 May;105(10):3793-801.

  4. Ries C, Egea V, Karow M, Kolb H, Jochum M, Neth P. MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines. Blood. 2007 May;109(9):4055-63.

  5. Gonjalves RM, Antunes JC, Barbosa MA. Mesenchymal stem cell recruitment by stromal derived factor-1-delivery systems based on chitosan/poly(y-glutamic acid) polyelec-trolyte complexes. Eur Cell Mater. 2012 Apr;23:249-60.

  6. Wynn RF, Hart CA, Corradi-Perini C, O'Neill L, Evans CA, Wraith JE, Fairbairn LJ, Bellantuono I. A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. Blood. 2004 Nov;104(9):2643-5.

  7. Yang C, Lei D, Ouyang W, Ren J, Li H, Hu J, Huang SL. Conditioned media from human adipose tissue-derived mesenchymal stem cells and umbilical cord-derived mesenchymal stem cells efficiently induced the apoptosis and differentiation in human glioma cell lines in vitro. Biomed Res Int. 2014;2014:109389.

  8. Calio ML, Marinho DS, Ko GM, Ribeiro RR, Carbonel AF, Oyama LM, Ormanji M, Guirao TP, Calio PL, Reis LA, Simoes Mde J, Lisboa-Nascimento T, Ferreira AT, Bertoncini CR. Transplantation of bone marrow mesenchymal stem cells decreases oxidative stress, apoptosis, and hippocampal damage in brain of a spontaneous stroke model. Free Radic Biol Med. 2014 May;70:141-54.

  9. Yu B, Zhang X, Li X. Exosomes derived from mesenchymal stem cells. Int J Mol Sci. 2014 Mar;15(3):4142-57.

  10. Honoki K, Tsujiuchi T. Senescence bypass in mesenchymal stem cells: a potential pathogenesis and implications of pro-senescence therapy in sarcomas. Exp Rev Anticancer Ther. 2013 Aug;13(8):983-96.

  11. Serakinci N, Guldberg P, Burns JS, Abdallah B, Schredder H, Jensen T, Kassem M. Adult human mesenchymal stem cell as a target for neoplastic transformation. Oncogene. 2004 Jun;23(29):5095-8.

  12. Serakinci N, Christensen R, Fahrioglu U, Sorensen FB, Dagnss-Hansen F, Hajek M, Jensen TH, Kolvraa S, Keith NW. Mesenchymal stem cells as therapeutic delivery vehicles targeting tumor stroma. Cancer Biother Radiopharm. 2011 Dec;26(6):767-73.

  13. D'Souza A, Lacy M, Gertz M, Kumar S, Buadi F, Hayman S, Dingli D, Zeldenrust S, Kyle R, Ansell S, Inwards D, Johnston P, Micallef I, Porrata L, Litzow M, Gastineau D, Hogan W, Dispenzieri A. Long-term outcomes after autologous stem cell transplantation for patients with POEMS syndrome (osteosclerotic myeloma): a single-center experience. Blood. 2012 Jul;120(1):56-62.

  14. Sohni A, Verfaillie CM. Mesenchymal stem cells migration homing and tracking. Stem Cells Int. 2013;2013:1-8.

  15. Ajith TA. Strategies used in the clinical trials of gene therapy for cancer. J Exp Ther Oncol. 2015;11(1):33-9.

  16. Bowie C. Development of engineered cells for implantation in gene therapy. Adv Drug Deliv Rev. 1998 Aug;33(1- 2):31.

  17. Liu S-X, Xia Z-S, Zhong Y-Q. Gene therapy in pancreatic cancer. World J Gastroenterol. 2014 Oct;20(37):13343-68.

  18. Nayerossadat N, Ali P, Maedeh T. Viral and nonviral delivery systems for gene delivery. Adv Biomed Res. 2012;1(1):27.

  19. Lessard S, Francioli L, Alfoldi J, Tardif J, Ellinor PT. Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci. Proc Natl Acad Sci. 2017;11257-66.

  20. Momin EN, Mohyeldin A, Zaidi HA, Vela G, Quinones-Hinojosa A. Mesenchymal stem cells: new approaches for the treatment of neurological diseases. Curr Stem Cell Res Ther. 2010 Dec;5(4):326-44.

  21. Aboody KS, Najbauer J, Danks MK. Stem and progenitor cell-mediated tumor selective gene therapy. Gene Ther. 2008 May;15(10):739-52.

  22. Mooney R, Weng Y, Tirughana-Sambandan R, Valenzuela V, Aramburo S, Garcia E, Li Z, Gutova M, Annala AJ, Berlin JM, Aboody KS. Neural stem cells improve intracranial nanoparticle retention and tumor-selective distribution. Future Oncol. 2014 Feb;10(3):401-15.

  23. Gao Z, Zhang L, Hu J, Sun Y. Mesenchymal stem cells: a potential targeted-delivery vehicle for anti-cancer drug, loaded nanoparticles. Nanomedicine. 2013 Feb;9(2):174- 84.

  24. Baglio SR, Rooijers K, Koppers-Lalic D, Verweij FJ, Perez Lanzon M, Zini N, Naaijkens B, Perut F, Niessen HW, Baldini N, Pegtel DM. Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species. Stem Cell Res Ther. 2015 Jul;6(1):127.

  25. Bliss SA, Sinha G, Sandiford OA, Williams LM, Engelberth DJ, Guiro K, Isenalumhe LL, Greco SJ, Ayer S, Bryan M, Kumar R, Ponzio NM, Rameshwar P. Mesenchymal stem cell-derived exosomes stimulate cycling quiescence and early breast cancer dormancy in bone marrow. Cancer Res. 2016 Oct;76(19):5832-44.

  26. Zhu Y, Cheng M, Yang Z, Zeng C-Y, Chen J, Xie Y, Luo SW, Zhang KH, Zhou SF, Lu NH. Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts. Drug Des Devel Ther. 2014 Dec;8:2449-62.

  27. Niess H, Bao Q, Conrad C, Zischek C, Notohamiprodjo M, Schwab F, Schwarz B, Huss R, Jauch KW, Nelson PJ, Bruns CJ. Selective targeting of genetically engineered mesenchymal stem cells to tumor stroma microenvironments using tissue-specific suicide gene expression suppresses growth of hepatocellular carcinoma. Ann Surg. 2011 Nov;254(5):767-74.

  28. 28. Sage EK, Thakrar RM, Janes SM. Genetically modified mesenchymal stromal cells in cancer therapy. Cytotherapy. 2016 Nov;18(11):1435-45.

  29. Shah K. Encapsulated stem cells for cancer therapy. Biomatter. 2013 Jan;3(1):e24278.

  30. Menon LG, Kelly K, Yang HW, Kim S-K, Black PM, Carroll RS. Human bone marrow-derived mesenchymal stromal cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapy. Stem Cells. 2009 Sep;27(9):2320-30.

  31. Studeny M, Marini FC, Champlin RE, Zompetta C, Fidler IJ, Andreeff M. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res. 2002 Jul;62(13):3603-8.

  32. Studeny M, Marini FC, Dembinski JL, Zompetta C, Cabreira-Hansen M, Bekele BN, Champlin RE, Andreeff M. Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents. J Natl Cancer Inst. 2004 Nov;96(21):1593-603.

  33. Placencio VR, Li X, Sherrill TP, Fritz G, Bhowmick NA. Bone marrow derived mesenchymal stem cells incorporate into the prostate during regrowth. PLoS One. 2010 Sep;5(9):e12920.

  34. Seo SH, Kim KS, Park SH, Suh YS, Kim SJ, Jeun S-S, Sung YC. The effects of mesenchymal stem cells injected via different routes on modified IL-12-mediated antitumor activity. Gene Ther. 2011 May;18(5):488-95.

  35. Pacioni S, D'Alessandris QG, Giannetti S, Morgante L, Cocce V, Bonomi A, Buccarelli M, Pascucci L, Alessandri G, Pessina A, Ricci-Vitiani L, Falchetti ML, Pallini R. Human mesenchymal stromal cells inhibit tumor growth in orthotopic glioblastoma xenografts. Stem Cell Res Ther. 2017 Dec;8(1):53.

  36. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011 Mar;144(5):646-74.

  37. Serakinci N, Christensen R, Graakjaer J, Cairney CJ, Keith WN, Alsner J, Saretzki G, Kolvraa S. Ectopically hTERT expressing adult human mesenchymal stem cells are less radiosensitive than their telomerase negative counterpart. Exp Cell Res. 2007 Mar;313(5):1056-67.

  38. Serakinci N, Graakjaer J, Kolvraa S. Telomere stability and telomerase in mesenchymal stem cells. Biochimie. 2008 Jan;90(1):33-40.

  39. Furlani D, Ugurlucan M, Ong L, Bieback K, Pittermann E, Westien I, Wang W, Yerebakan C, Li W, Gaebel R, Li RK, Vollmar B, Steinhoff G, Ma N. Is the intravascular admin-istration of mesenchymal stem cells safe? Mesenchymal stem cells and intravital microscopy. Microvasc Res. 2009 May;77(3):370-6.

  40. Hiyama E, Hiyama K. Telomere and telomerase in stem cells. Br J Cancer. 2007 Apr;96(7):1020-4.

  41. Amariglio N, Hirshberg A, Scheithauer BW, Cohen Y, Loewenthal R, Trakhtenbrot L, Paz N, Koren-Michowitz M, Waldman D, Leider-Trejo L, Toren A, Constantini S, Rechavi G. Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Med. 2009 Feb;6(2):e1000029.

  42. Kaji K, Norrby K, Paca A, Mileikovsky M, Mohseni P, Woltjen K. Virus-free induction of pluripotency and sub-sequent excision of reprogramming factors. Nature. 2009 Apr;458(7239):771-5.

  43. Oricchio E, Papapetrou EP, Lafaille F, Ganat YM, Kriks S, Ortega-Molina A, Mark WH, Teruya-Feldstein J, Huse JT, Reuter V, Sadelain M, Studer L, Wendel HG. A cell engineering strategy to enhance the safety of stem cell therapies. Cell Rep. 2014 Sep;8(6):1677-85.

  44. Wang Y, Huso DL, Harrington J, Kellner J, Jeong DK, Turney J, McNiece IK. Outgrowth of a transformed cell population derived from normal human BM mesenchymal stem cell culture. Cytotherapy. 2005;7(6):509-19.

  45. Rubio D, Garcia S, De la Cueva T, Paz MF, Lloyd AC, Bernad A, Garcia-Castro J. Human mesenchymal stem cell transformation is associated with a mesenchymal-epithelial transition. Exp Cell Res. 2008 Feb;314(4):691-8.

  46. Bernardo ME, Zaffaroni N, Novara F, Cometa AM, Avanzini MA, Moretta A, Moretta A, Montagna D, Maccario R, Villa R, Daidone MG, Zuffardi O, Locatelli F. Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms. Cancer Res. 2007 Oct;67(19):9142-9.

  47. Meza-Zepeda LA, Noer A, Dahl JA, Micci F, Myklebost O, Collas P. High-resolution analysis of genetic stability of human adipose tissue stem cells cultured to senescence. J Cell Mol Med. 2008 Apr;12(2):553-63.

  48. Burns JS, Abdallah BM, Guldberg P, Rygaard J, Schroder HD, Kassem M. Tumorigenic heterogeneity in cancer stem cells evolved from long-term cultures of telomerase-immortalized human mesenchymal stem cells. Cancer Res. 2005 Apr;65(8):3126-35.

  49. Scherzad A, Steber M, Gehrke T, Rak K, Froelich K, Schendzielorz P, Hagen R, Kleinsasser N, Hackenberg S. Human mesenchymal stem cells enhance cancer cell pro-liferation via IL-6 secretion and activation of ERK1/2. Int J Oncol. 2015 May;47(1):391-7.

  50. De Luca A, Lamura L, Gallo M, Maffia V, Normanno N. Mesenchymal stem cell-derived interleukin-6 and vascular endothelial growth factor promote breast cancer cell migration. J Cell Biochem. 2012 Nov;113(11):3363-70.

  51. Yi B, Kim SU, Kim Y, Lee HJUN, Cho M, Choi K. Antitumor effects of genetically engineered stem cells expressing yeast cytosine deaminase in lung cancer brain metastases via their tumor-tropic properties. Oncol Rep. 2012;1823-8.

  52. Yi B, Kang N, Hwang K, Kim SU, Jeung EB, Kim YB, Heo GJ, Choi KC. Genetically engineered stem cells expressing cytosine deaminase and interferon-P migrate to human lung cancer cells and have potentially therapeutic anti-tumor effects. Int J Oncol. 2011;(19):833-9.

  53. Qin J, Zhao Y, Wang Y, Betzler C, Popp FC, Augsburger D, Gupta AS, Augsburger D, Camaj P, Nelson PJ, Bruns CJl. Therapeutic potential of mesenchymal stem cells in gas-trointestinal cancers-current evidence. Gastrointestinal cancer: targets and therapy. Auckland, New Zealand: Dove Press; 2016. p. 41-7.

  54. Mavroudi M, Zarogoulidis P, Porpodis K, Kioumis I, Yarmus L, Malecki R,Zarogoulidis K, Malecki M. Stem cells' guided gene therapy of cancer: new frontier in personalized and targeted therapy. J Cancer Res Ther. 2014;2(1):22-33.

  55. Abdul-Ghani R, Ohana P, Matouk I, Ayesh S, Ayesh B, Laster M, Bibi O, Giladi H, Molnar-Kimber K, Sughayer MA, De Groot N. Use of transcriptional regulatory sequences of telomerase (hTER and hTERT) for selective killing of cancer cells. Mol Ther. 2000 Dec;2(6):539-44.

  56. Komata T, Koga S, Hirohata S, Takakura M, Germano IM, Inoue M, Kyo S, Kondo S, Kondo Y. A novel treatment of human malignant gliomas in vitro and in vivo: FADD gene transfer under the control of the human telomerase reverse transcriptase gene promoter. Int J Oncol. 2001 Nov;19(5):1015-20.

  57. Plumb JA, Bilsland A, Kakani R, Zhao J, Glasspool RM, Knox RJ, Evans TR, Keith WN. Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the prodrug CB1954. Oncogene. 2001 Nov;20(53):7797-803.

  58. Yashima K, Piatyszek MA, Saboorian HM, Virmani AK, Brown D, Shay JW, Gazdar AF. Telomerase activity and in situ telomerase RNA expression in malignant and non-malignant lymph nodes. J Clin Pathol. 1997 Feb;50(2):110-7.

  59. Joseph I, Tressler R, Bassett E, Harley C, Buseman CM, Pattamatta P, Wright WE, Shay JW, Go NF. The telo-merase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines. Cancer Res. 2010 Nov;70(22):9494-504.

  60. Resnick IB, Barkats C, Shapira MY, Stepensky P, Bloom AI, Shimoni A, Mankuta D, Varda-Bloom N, Rheingold L, Yeshurun M, Bielorai B, Toren A, Zuckerman T, Nagler A, Or R. Treatment of severe steroid resistant acute GVHD with mesenchymal stromal cells (MSC). Am J Blood Res. 2013;3(3):225-38.

  61. Barkholt L, Flory E, Jekerle V, Lucas-Samuel S, Ahnert P, Bisset L, Buscher D, Fibbe W, Foussat A, Kwa M, Lantz O, Maciulaitis R, Palomaki T, Schneider CK, Sensebe L, Tachdjian G, Tarte K, Tosca L, Salmikangas P. Risk of tumorigenicity in mesenchymal stromal cell-based therapies-bridging scientific observations and regulatory viewpoints. Cytotherapy. 2013 Jul;15(7):753-9.

Articles with similar content:

Gene Expression in Stem Cells Critical Reviews™ in Eukaryotic Gene Expression, Vol.19, 2009, issue 4
Yu Liang, Criss Walworth, Iain Russell, Caifu Chen
Three- and Four-Dimensional Spheroid and FiSS Tumoroid Cultures: Platforms for Drug Discovery and Development and Translational Research Critical Reviews™ in Therapeutic Drug Carrier Systems, Vol.34, 2017, issue 3
S. Padhee, R. R. Nair, Subhra Mohapatra, S. S. Mohapatra, R. Green, T. Das, M. Howell
An Updated Review of Oral Cancer Stem Cells and Their Stemness Regulation Critical Reviews™ in Oncogenesis, Vol.23, 2018, issue 3-4
Reuben H. Kim, Ki-Hyuk Shin
Stem Cells: A New Paradigm in Medical Therapeutics Journal of Long-Term Effects of Medical Implants, Vol.20, 2010, issue 3
Sadanand D. Mankikar
Dental Tissue−Derived Mesenchymal Stem Cells: Applications in Tissue Engineering Critical Reviews™ in Biomedical Engineering, Vol.46, 2018, issue 5
Jay R. Dave, Geetanjali B. Tomar

Latest Issue

Peptidomics Analysis Reveals Serum Biomarkers in Spinal Cord Injury Patients Yanyin Zhao, Dake Tong, Miao Wang, Changli Xu, Xiaoqian Gong, Zhiwei Wang, Cheng Li Immune Infiltration Landscape on Identified Molecular Subtypes of Chronic Kidney Disease Fei Li, Mengjie Huang, Zhuo Gao, Xiaomeng lv, Ribao Wei, Xiangmei Chen Identification and Molecular Mechanisms Study of Genes Associated with Osteoarthritis: A Comprehensive Bioinformatic Study of Cartilage and Synovium Shuai Li, Xiaoquan Wang, Jingxian Li, Wuzeng Wei, Jun Liu

Forthcoming Articles

MiR-671-5p promotes cell proliferation, invasion, and migration in hepatocellular carcinoma through targeting ALDH2 Xiao Chen, Jiansheng Luo, Shengqiang Gao, Jinghua Jiang, Bin Yang, Zhaohui Zhang MiR-335-5p Targets SDC1 to Regulate Progression of Breast Cancer Guoqing Song, Yao Ma, Yinghan Ma, Pan Liu, Lu Hou, Zijian Xu, Jialing Jiang, Yang Shen, Yanan Cao, Yi Zhao miR-15a-5p regulates liver cancer cell migration, apoptosis and cell cycle progression by targeting transcription factor E2F3 Yulong Li, Dan Li, Yang Yang, Jingjie Wang lncRNA Linc00511 upregulation elevates TGFBR1 and participates in the postoperative distant recurrence of non-small cell lung cancer by targeting miR-98-5p chunling li, zhenyu li, hua yi, zhidong liu Persuasion Via Performance: Toward a Handbook for Youth to Develop Content that Promotes HPV Vaccination Matthew Dugan, Katherine McAllister MiR-532-5p inhibits non-small cell lung cancer progression in vivo and in vitro by targeting Yin Yang 1 Song Li, Chunlin Zhu, Quandong Wang, Yongsi Wen GAS5 suppresses cell proliferation, migration, and invasion via the miR-455–5p/CDKN1B axis in cutaneous squamous cell carcinoma Jing Wei, Ying Zeng, Qian Yang, Huan Ke, Guili Fu, Yuanquan Zheng, Jingjing Lu Regulatory effects of LncRNA SNHG4 on miR-25/FBXW7 axis in papillary thyroid cancer cells Hai Lan tRNA-derived fragment tRF-18 facilitates cell proliferation and inhibits cell apoptosis via modulating KIF1B in papillary thyroid carcinoma Xingyi Lu, Wenze Wu, Donglin Sun, Jianfeng Sang MiR-1285 Restrains Gastric Cancer Cell Growth and Causes Apoptosis by Negatively Regulating RAB1A Yali Lei, Jing Chen, Ning Wang, Hailin Ma, Yongning Zhang, Fengqiang Hou Comprehensive analysis of centromere protein family member genes in lung adenocarcinoma XiaoPing Li, Pan Yang, Xiong Pei, JiaHui Deng ciRS-7 enhances the progression of hepatocellular carcinoma through miR-944/NOX4 pathway Chuangjie Mao, Huitao Wen, Yiqian Zhang, Ge Yu, Qui Ge LncRNA MCM3AP-AS1 regulates miR-21/PTEN axis to participate in the regulation of cervical squamous cell carcinoma cell proliferation and apoptosis Gang Yan, Zhangcai Wan, Yechao Zhong, Manling Chen CircRNA CircRIMS downregulates miR-505 through methylation to suppress cell proliferation in endometrial cancer Zhizhong Chen, Yindi Sun, Hao Dong, Feiyue Zhang, Huirong Xu, Jing Zhang miR-137 modulates human gastric cancer cell proliferation, apoptosis and migration by targeting EZH2 Xiao-qi Weng, Wei Wang Overexpressed lncRNA GATA3-AS1 in preeclampsia and its effects on trophoblast proliferation and migration by the miR-488-3p/ROCK1 axis Yulei Zhang, Hongxue Liu, Xiaoming Shu, Yanlan Sun, Xiaoqin Chen Steroid receptor coactivator-1 (SRC-1) promoted cell metastasis of Gastric cancer via VEGFC activator by NF-?B Xiaojun Zhao, Xiaolan You, Chuanjiang Huang, Guiyuan Liu, Zhiyi Cheng, Haitao Zhang LGR6 acts as an oncogene and induces proliferation and migration of gastric cancer cells Meiyang Fan, Siyuan Liu, Lingyu Zhang, Shanfeng Gao, Rufeng Li, Xiaofan Xiong, Lin Han, Xuan Xiao, Lingyu Zhao, Dongdong Tong, Juan Yang MiR-369-5p positively modulates plasticity-related proteins in hippocampal cultures and in a mouse model of Alzheimer’s disease Yu Liu, Qingwei Xiang Apolipoprotein C1 (APOC1), a candidate diagnostic serum biomarker for breast cancer identified by serum proteomics study yu yan, Yuhui zhou, ke wang, lingyu zhao, yan qiao, mingwei chen UHRF1 associated with osteogenic differentiation of MSCs contributes to osteosarcoma progression and has clinical prognostic impact in osteosarcoma Zimo Zhou, Da Liu, Sen Qin, Senxiang Chen LncRNA SCIRT is downregulated in acute myeloid leukemia and sponges miR-21 in cytoplasm to increase chemosensitivity to doxorubicin Haixia Li, Xuefei Tian, Tian Nie, Mao Huang, Zhenghui Xiao Prognostic Value of NUSAP1 and Its Correlation with Immune Infiltrates in Human Breast Cancer Mingjun Li, Bo Yang PD-L1 overexpression in lung of subjects died for COVID-19. On the way to understand the immune system exhaustion induced by SARS-CoV-2? Andrea Ronchi, Federica Zito Marino, Emma Carraturo, Elvira La Mantia, Carlo Pietro Campobasso, Francesco De Micco, Pasquale Mascolo, Maurizio Municinò, Emilia Municinò, Francesco Vestini, Omero Pinto, Marta Moccia, Noè De Stefano, Oscar Nappi, Carmen Sementa, Giovanni Zotti, Lamberto Pianese, Carmela Giordano, Antonio Fico, Renato Franco Oncogenic long noncoding RNA Linc01287 promotes IGF1R expression by sponging miR-98 in breast cancer Chen xu Guo, Ming Zhang, Peng cheng Li, Lou ming Guo, Jun Qian Identification of biomarkers associated with hepatocellular carcinoma stem cell characteristics based on co-expression network analysis of transcriptome data and stemness inde Zheng Zhao, Huiwen Mu, Shaofang Feng, Yunxin Liu, Jianjun Zou, Yubing Zhu Repression of Cell to Matrix Adhesion by Metformin Chloride Supports its Anti-Metastatic Potential in an in vitro Study on Metastatic and Non-Metastatic Cancer Cells Saira Aftab, Zumama Khalid, Abdul Rauf Shakoori Role of circular RNAs in the pathogenesis of malignant melanoma Lele Cong, Hongfeng Yang, Hongyan Sun, Miao Hao, Chenlu Liu, Yang Zheng, Xianling Cong, Rihua Jiang Labor Analgesia: A systematic review and meta-analysis of non-pharmacological complementary and alternative approaches to pain during first stage of labor Antonio Melillo, Patrizia Maiorano, Sarah Rachedi, Giuseppe Caggianese, Elisabetta Gragnano, Luigi Gallo, Giuseppe De Pietro, Maurizio Guida, Antonio Giordano, Andrea Chirico LncRNA KTN1-AS1 silencing inhibits non-small cell lung cancer cell proliferation and KTN1-AS1 expression predicts survival Feng Wu, Linlin Wang, Liqiang Xu, Shimao Song, Meng Liang LncRNA DSCAM-AS1 negatively interacts with miR-124 to promote hepatocellular carcinoma proliferation Zheng Wang, Shengmian Li, Gaili Zhang
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain