Library Subscription: Guest
Critical Reviews™ in Eukaryotic Gene Expression

Published 6 issues per year

ISSN Print: 1045-4403

ISSN Online: 2162-6502

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.6 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.2 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00058 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.33 SJR: 0.345 SNIP: 0.46 CiteScore™:: 2.5 H-Index: 67

Indexed in

The Regulation and Regulatory Role of Collagenase in Bone

Volume 6, Issue 1, 1996, pp. 15-27
DOI: 10.1615/CritRevEukarGeneExpr.v6.i1.20
Get accessGet access

ABSTRACT

Interstitial collagenase plays an important role in both the normal and pathological remodeling of collagenous extracellular matrices, including skeletal tissues. The enzyme is a member of the family of matrix metalloproteinases. Only one rodent interstitial collagenase has been found but there are two human enzymes, human collagenase-1 and -3, the latter being the homologue of the rat enzyme. In developing rat and mouse bone, collagenase is expressed by hypertrophic chondrocytes, osteoblasts, and osteocytes, a situation that is replicated in a fracture callus. Cultured osteoblasts derived from neonatal rat calvariae show greater amounts of collagenase transcripts late in differentiation. These levels can be regulated by parathyroid hormone (PTH), retinoic acid, and insulin-like growth factors, as well as the degree of matrix mineralization. Much of the work on collagenase in bone has been derived from studies on the rat osteosarcoma cell line, UMR 106-01. All bone-resorbing agents stimulate these cells to produce collagenase mRNA and protein, with PTH being the most potent stimulator. Determination of secreted levels of collagenase has been difficult because UMR cells, normal rat osteoblasts, and rat fibroblasts possess a scavenger receptor that removes the enzyme from the extracellular space, internalizes and degrades it, thus imposing another level of control. PTH can also regulate the abundance of the receptor as well as the expression and synthesis of the enzyme. Regulation of the collagenase gene by PTH appears to involve the cAMP pathway as well as a primary response gene, possibly Fos, which then contributes to induction of the collagenase gene. The rat collagenase gene contains an activator protein-1 sequence that is necessary for basal expression, but other promoter regions may also participate in PTH regulation. Thus, there are many levels of regulation of collagenase in bone perhaps constraining what would otherwise be a rampant enzyme.

CITED BY
  1. WLER GORDON J. STRE, Physiologic Actions of PTH and PTHrP, in The Parathyroids, 2001. Crossref

  2. CLARK IAN M., MURPHY GILLIAN, Matrix Proteinases, in Dynamics of Bone and Cartilage Metabolism, 2006. Crossref

  3. Hecht Monica, Heider Ulrike, Kaiser Martin, von Metzler Ivana, Sterz Jan, Sezer Orhan, Osteoblasts promote migration and invasion of myeloma cells through upregulation of matrix metalloproteinases, urokinase plasminogen activator, hepatocyte growth factor and activation of p38 MAPK, British Journal of Haematology, 138, 4, 2007. Crossref

  4. Li Changjun, Xing Qiujuan, Yu Bing, Xie Hui, Wang Weishan, Shi Chenhui, Crane Janet L, Cao Xu, Wan Mei, Disruption of LRP6 in osteoblasts blunts the bone anabolic activity of PTH, Journal of Bone and Mineral Research, 28, 10, 2013. Crossref

  5. Titorencu Irina, Pruna Vasile, Jinga Victor V., Simionescu Maya, Osteoblast ontogeny and implications for bone pathology: an overview, Cell and Tissue Research, 355, 1, 2014. Crossref

  6. Oum'hamed Z., Garnotel R., Josset Y., Trenteseaux C., Laurent-Maquin D., Matrix metalloproteinases MMP-2, -9 and tissue inhibitors TIMP-1, -2 expression and secretion by primary human osteoblast cells in response to titanium, zirconia, and alumina ceramics, Journal of Biomedical Materials Research, 68A, 1, 2004. Crossref

  7. Hock Janet M., Stemming bone loss by suppressing apoptosis, Journal of Clinical Investigation, 104, 4, 1999. Crossref

  8. Hock J. M., Krishnan V., Onyia J. E., Bidwell J. P., Milas J., Stanislaus D., Osteoblast Apoptosis and Bone Turnover, Journal of Bone and Mineral Research, 16, 6, 2001. Crossref

  9. LOCHTER ANDRÉ, BISSELL MINA J., An odyssey from breast to bone: Multi-step control of mammary metastases and osteolysis by matrix metalloproteinases, APMIS, 107, 1-6, 1999. Crossref

  10. Ozeki Nobuaki, Kawai Rie, Yamaguchi Hideyuki, Hiyama Taiki, Kinoshita Katsue, Hase Naoko, Nakata Kazuhiko, Kondo Ayami, Mogi Makio, Nakamura Hiroshi, RETRACTED: IL-1β-induced matrix metalloproteinase-13 is activated by a disintegrin and metalloprotease-28-regulated proliferation of human osteoblast-like cells, Experimental Cell Research, 323, 1, 2014. Crossref

  11. Hömme M., Schaefer F., Mehls O., Schmitt C. P., Differential Regulation of RGS-2 by Constant and Oscillating PTH Concentrations, Calcified Tissue International, 84, 4, 2009. Crossref

  12. Gasparrini Marco, Rivas Daniel, Elbaz Alexandre, Duque Gustavo, Differential expression of cytokines in subcutaneous and marrow fat of aging C57BL/6J mice, Experimental Gerontology, 44, 9, 2009. Crossref

  13. Hayami Takayuki, Kapila Yvonne L., Kapila Sunil, MMP-1 (collagenase-1) and MMP-13 (collagenase-3) differentially regulate markers of osteoblastic differentiation in osteogenic cells, Matrix Biology, 27, 8, 2008. Crossref

  14. Hayami Takayuki, Kapila Yvonne L., Kapila Sunil, Divergent upstream osteogenic events contribute to the differential modulation of MG63 cell osteoblast differentiation by MMP-1 (collagenase-1) and MMP-13 (collagenase-3), Matrix Biology, 30, 4, 2011. Crossref

  15. Ek Eugene T.H., Dass Crispin R., Choong Peter F.M., Commonly used mouse models of osteosarcoma, Critical Reviews in Oncology/Hematology, 60, 1, 2006. Crossref

  16. Xing Lianping, Boyce Brendan F., Regulation of apoptosis in osteoclasts and osteoblastic cells, Biochemical and Biophysical Research Communications, 328, 3, 2005. Crossref

  17. Swarthout John T., D'Alonzo Richard C., Selvamurugan Nagarajan, Partridge Nicola C., Parathyroid hormone-dependent signaling pathways regulating genes in bone cells, Gene, 282, 1-2, 2002. Crossref

  18. Jiménez Maria J.G., Balbín Milagros, Alvarez Jesús, Komori Toshihisa, Bianco Paolo, Holmbeck Kenn, Birkedal-Hansen Henning, López José M., López-Otín Carlos, A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation, Journal of Cell Biology, 155, 7, 2001. Crossref

  19. Tsuru Michiyo, Sata Michio, Tanaka Maki, Umeyama Hideaki, Kodera Yoshio, Shiwa Mieko, Aoyagi Norikazu, Yasuda Kaori, Matsuoka Kei, Fukuda Takaaki, Yamana Hideaki, Nagata Kensei, Retrospective Proteomic Analysis of a Novel, Cancer Metastasis-Promoting RGD-Containing Peptide, Translational Oncology, 10, 6, 2017. Crossref

  20. Kim Myungsuk, Lim Jisun, Lee Jung-Hee, Lee Kyung-Mi, Kim Suji, Park Kye Won, Nho Chu Won, Cho Yoon Shin, Understanding the functional role of genistein in the bone differentiation in mouse osteoblastic cell line MC3T3-E1 by RNA-seq analysis, Scientific Reports, 8, 1, 2018. Crossref

  21. Fahmy-Garcia Shorouk, Mumcuoglu Didem, de Miguel Laura, Dieleman Veerle, Witte-Bouma Janneke, van der Eerden Bram C. J., van Driel Marjolein, Eglin David, Verhaar Jan A. N., Kluijtmans Sebastiaan G. J. M., van Osch Gerjo J. V. M., Farrell Eric, Novel In Situ Gelling Hydrogels Loaded with Recombinant Collagen Peptide Microspheres as a Slow-Release System Induce Ectopic Bone Formation, Advanced Healthcare Materials, 7, 21, 2018. Crossref

  22. Richard Bringhurst F., Strewler Gordon J., Renal and Skeletal Actions of Parathyroid Hormone (PTH) and PTH-Related Protein, in Principles of Bone Biology, 2002. Crossref

  23. Boyce Brendan F., Xing Lianping, Jilka Robert L., Bellido Teresita, Weinstein Robert S., Parfitt A. Michael, Manolagas Stavros C., Apoptosis in Bone Cells, in Principles of Bone Biology, 2002. Crossref

  24. Cojocaru Florina Daniela, Balan Vera, Popa Ionel Marcel, Munteanu Anca, Anghelache Anisoara, Verestiuc Liliana, Magnetic Composite Scaffolds for Potential Applications in Radiochemotherapy of Malignant Bone Tumors, Medicina, 55, 5, 2019. Crossref

  25. D'Alonzo Richard C., Selvamurugan Nagarajan, Karsenty Gerard, Partridge Nicola C., Physical Interaction of the Activator Protein-1 Factors c-Fos and c-Jun with Cbfa1 for Collagenase-3 Promoter Activation, Journal of Biological Chemistry, 277, 1, 2002. Crossref

  26. D'Alonzo Richard C., Kowalski Aaron J., Denhardt David T., Nickols G. Allen, Partridge Nicola C., Regulation of Collagenase-3 and Osteocalcin Gene Expression by Collagen and Osteopontin in Differentiating MC3T3-E1 Cells, Journal of Biological Chemistry, 277, 27, 2002. Crossref

  27. Jiménez Maria J. G., Balbín Milagros, López José M., Alvarez Jesús, Komori Toshihisa, López-Otín Carlos, Collagenase 3 Is a Target of Cbfa1, a Transcription Factor of the runt Gene Family Involved in Bone Formation , Molecular and Cellular Biology, 19, 6, 1999. Crossref

Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain